Antioxidant Enzymes and Lipid Peroxidation in Different Stages of Breast Cancer

Abstract

Oxidative stress resulting from an imbalance between pro-oxidants and anti-oxidants seems to play an important role in human breast carcinogenesis. There are conflicting reports regarding the tissue levels of malondialdehyde (MDA), ascorbic acid and superoxide dismutase (SOD) in breast cancer patients whereas few blood values have been reported. The present study was carried out to observe the changes in serum MDA, serum SOD and plasma ascorbic acid with the stage-wise progression of the disease. Serum MDA and serum SOD levels were found to be increased gradually from Stage I to Stage IV as compared to control group (p < 0.001). The maximum rise was in Stage IV patients. In contrast, mean plasma ascorbic acid levels were low in all stages compared to control group (p < 0.001). The decrease was more pronounced in Stage III and Stage IV. The study would be of immense help for establishing blood based biochemical marker in breast cancer patients.

The 8‐epimer of prostaglandin F2α, a marker of lipid peroxidation and oxidative stress, is decreased in the nipple aspirate fluid of women with breast cancer

“…8 Several studies have found enhanced lipid peroxidation and depletion of antioxidants in the plasma of BC patients, suggesting that increased oxidative stress may be related to human breast carcinogenesis. [9][10][11][12][13] Moreover, an increased content of lipid peroxidation products was found in BC tissue, supporting the hypothesis of breast tumorigenesis by in situ oxidative stress. 14,15 On the other hand, recent reports suggest that lipid peroxidation may represent a protective mechanism in BC through the induction of apoptosis, thereby maintaining the balance between breast epithelial cell growth and death, 8,16 supporting the hypothesis that lipid peroxidation in tissue of benign breast disease (BBD) is greater than in BC.…”

New Aspects of Therapy of Hepatocellular Carcinoma Egyptian Patients

“…Moreover, Madan et al [83] proved that the combination regimen containing chemotherapy in addition to vitamin E appears to be effective in normalizing amino transferases among nonalcoholic fatty liver disease suffering patients. The nutritional non-enzymatic antioxidants were increased in their serum levels in HCC patients as regards Nigella Sativa oil and fish oil supplementation when compared with control subjects this agree with data performed by Khanzode et al [84] they reported that the Zinc which is not a proper antioxidant but is an important cofactor incorporated into an intracellular antioxidant enzyme (superoxide dismutase) can ameliorate the dysfunction state occurring in HCC suffering individuals.…”

Oxidative Therapy Against Cancer

“…In some cases, there are differences between different antioxidants in the same patient; some increase and others decrease (Ray et al, 2000). In breast cancer, for example, several studies describe an increase of lipid peroxidation and a decrease of antioxidants (Khanzode et al, 2004;Sener et al, 2007). However, other studies performed in neoplastic tissues have shown a greater presence of ROS and a high expression of antioxidants (Oltra et al, 2001;Gönenç et al, 2006).…”