Antioxidant enzymes gene expression and antihypertensive effects of seaweeds Ulva linza and Lessonia trabeculata in rats fed a high-fat and high-sucrose diet

Ramírez-Higuera, Abril; Quevedo-Corona, Lucı́a; Paniagua-Castro, Norma; Chamorro-Ceballos, Germán; Milliar-Garcia, Angel; Jaramillo-Flores, M. E.

doi:10.1007/s10811-013-0134-0

Cited by 20 publications

(6 citation statements)

References 18 publications

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“…On the basis of chemical composition of the two algae, the authors have suggested that the better scores of Ulva ohnoi with respect to those induced by Derbesia tenuissima could be due to its richness in soluble fibers and magnesium. A similar trend on blood pressure were also registered by Ramirez-Huigera et al [ 96 ], when testing the effects of diet-suplementation of Ulva linza and Lessonia trabeculata in rats fed with a hypercaloric diet.…”

Section: Evidences Of Protective Effects Of Seaweeds With Impact Osupporting

confidence: 83%

Seaweeds as Preventive Agents for Cardiovascular Diseases: From Nutrients to Functional Foods

et al. 2015

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Being naturally enriched in key nutrients and in various health-promoting compounds, seaweeds represent promising candidates for the design of functional foods. Soluble dietary fibers, peptides, phlorotannins, lipids and minerals are macroalgae’s major compounds that can hold potential in high-value food products derived from macroalgae, including those directed to the cardiovascular-health promotion. This manuscript revises available reported data focusing the role of diet supplementation of macroalgae, or extracts enriched in bioactive compounds from macroalgae origin, in targeting modifiable markers of cardiovascular diseases (CVDs), like dyslipidemia, oxidative stress, vascular inflammation, hypertension, hypercoagulability and activation of the sympathetic and renin-angiotensin systems, among others. At last, the review also describes several products that have been formulated with the use of whole macroalgae or extracts, along with their claimed cardiovascular-associated benefits.

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Section: Evidences Of Protective Effects Of Seaweeds With Impact Osupporting

confidence: 83%

Seaweeds as Preventive Agents for Cardiovascular Diseases: From Nutrients to Functional Foods

et al. 2015

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“…Some reports indicate that Undaria pinnatifida contains fatty acid EPA [ 28 , 29 ] that has been associated with diminishing blood flow and anti-inflammatory properties [ 29 ] associated to this condition. Also, previous studies but using different types of algae, have also proven the effectiveness of algae in reducing this parameter [ 30 ] by containing antioxidant molecules, fibers such as fucoidans, and by inhibiting the action of angiotensin converting enzyme [ 31 , 32 ]. Blood pressure is also linked to PAI-1 serum concentration, and this molecule acts as a pro inflammatory cytokine, and has been linked to thrombosis and fibrosis [ 10 ] which was diminished by treatments and could also explain the decrease on this parameter.…”

Section: Discussionmentioning

confidence: 99%

Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity

et al. 2016

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Brown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on white adipose tissue lipid metabolism in a murine model of diet-induced obesity. The treatments improved energy expenditure, β-oxidation and adipogenesis by upregulating PPARα, PGC1α, PPARγ and UCP-1. Adipogenesis was also confirmed by image analysis of the retroperitoneal adipose tissue, by measuring cell area, perimeter and cellular density. Additionally, the treatments, ameliorated adipose tissue accumulation, insulin resistance, blood pressure, cholesterol and triglycerides concentration in serum, and reduced lipogenesis and inflammation by downregulating acetyl-CoA carboxylase (ACC) gene expression, increasing serum concentration and expression of adiponectin as well as downregulating IL-6 expression. Both fucoxanthin and Undaria pinnatifida may be considered for treating obesity and other diseases related.

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“…Ulva species showed cholesterol-lowering and cardioprotective properties, as well as anti-inflammatory potential [ 14 , 15 ]. Supplementation of a high-calorie diet with the edible green seaweed Ulva linza lowered intra-abdominal fat pads by 35%, blood pressure by 35%, concentrations of blood glucose by 31%, and serum cholesterol and triglycerides concentrations by 17% and 20% [ 16 ]. The fast growth rate and broad geographical distribution of tropical species of Ulva , such as Ulva ohnoi (UO), could provide a sustainable source of these seaweeds for new applications as functional foods as they are suitable for intensive aquaculture production [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Seaweed Supplements Normalise Metabolic, Cardiovascular and Liver Responses in High-Carbohydrate, High-Fat Fed Rats

et al. 2015

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Increased seaweed consumption may be linked to the lower incidence of metabolic syndrome in eastern Asia. This study investigated the responses to two tropical green seaweeds, Ulva ohnoi (UO) and Derbesia tenuissima (DT), in a rat model of human metabolic syndrome. Male Wistar rats (330–340 g) were fed either a corn starch-rich diet or a high-carbohydrate, high-fat diet with 25% fructose in drinking water, for 16 weeks. High-carbohydrate, high-fat diet-fed rats showed the signs of metabolic syndrome leading to abdominal obesity, cardiovascular remodelling and non-alcoholic fatty liver disease. Food was supplemented with 5% dried UO or DT for the final 8 weeks only. UO lowered total final body fat mass by 24%, systolic blood pressure by 29 mmHg, and improved glucose utilisation and insulin sensitivity. In contrast, DT did not change total body fat mass but decreased plasma triglycerides by 38% and total cholesterol by 17%. UO contained 18.1% soluble fibre as part of 40.9% total fibre, and increased magnesium, while DT contained 23.4% total fibre, essentially as insoluble fibre. UO was more effective in reducing metabolic syndrome than DT, possibly due to the increased intake of soluble fibre and magnesium.

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Antioxidant enzymes gene expression and antihypertensive effects of seaweeds Ulva linza and Lessonia trabeculata in rats fed a high-fat and high-sucrose diet

Cited by 20 publications

References 18 publications

Seaweeds as Preventive Agents for Cardiovascular Diseases: From Nutrients to Functional Foods

Seaweeds as Preventive Agents for Cardiovascular Diseases: From Nutrients to Functional Foods

Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity

Seaweed Supplements Normalise Metabolic, Cardiovascular and Liver Responses in High-Carbohydrate, High-Fat Fed Rats

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