Antioxidant, Hepatoprotective and Antiatherogenic Effects of Curcumin on High Fat Diet Induced Dyslipidemia in Rats

Khan, Nazish Iqbal; Mahboob, Tabassum

doi:10.3923/pjn.2014.537.545

Cited by 2 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dietary fat consumption in mammals results in metabolic disturbances, including alterations in glucose tolerance [ 6 , 7 ], dyslipidaemia [ 8 ], and hepatic steatosis [ 7 , 9 ], amongst others. No studies to our knowledge have focussed on the impact of high-fat poultry diets on the serum clinical biochemistry, as a measure of the overall health status of alternative poultry species.…”

Section: Introductionmentioning

confidence: 99%

The effects of high-fat diets composed of different animal and vegetable fat sources on the health status and tissue lipid profiles of male Japanese quail (Coturnix coturnix japonica)

Donaldson

Madziva

Erlwanger

2016

Asian-Australas J Anim Sci

View full text Add to dashboard Cite

ObjectiveThe current study aimed to investigate the impact of high-fat diets composed of different animal and vegetable fat sources on serum metabolic health markers in Japanese quail, as well as the overall lipid content and fatty acid profiles of the edible bird tissues following significantly increased dietary lipid supplementation.MethodsFifty seven male quail were divided into six groups and fed either a standard diet or a diet enriched with one of five different fats (22% coconut oil, lard, palm oil, soybean oil, or sunflower oil) for 12 weeks. The birds were subjected to an oral glucose tolerance test following the feeding period, after which they were euthanized and blood, liver, breast, and thigh muscle samples collected. Total fat content and fatty acid profiles of the tissue samples, as well as serum uric acid, triglyceride, cholesterol, total protein, albumin, aspartate transaminase, and total bilirubin concentrations were assessed.ResultsHigh-fat diet feeding had no significant effects on the glucose tolerance of the birds. Dietary fatty acid profiles of the added fats were reflected in the lipid profiles of both the liver and breast and thigh muscle tissues, indicating successful transfer of dietary fatty acids to the edible bird tissues. The significantly increased level of lipid inclusion in the diets of the quail used in the present study was unsuccessful in increasing the overall lipid content of the edible bird tissues. Serum metabolic health markers in birds on the high-fat diets were not significantly different from those observed in birds on the standard diet.ConclusionThus, despite the various high-fat diets modifying the fatty acid profile of the birds’ tissues, unlike in most mammals, the birds maintained a normal health status following consumption of the various high-fat diets.

show abstract

Section: Introductionmentioning

confidence: 99%

The effects of high-fat diets composed of different animal and vegetable fat sources on the health status and tissue lipid profiles of male Japanese quail (Coturnix coturnix japonica)

Donaldson

Madziva

Erlwanger

2016

Asian-Australas J Anim Sci

View full text Add to dashboard Cite

show abstract

“…Although the present anticoagulant drugs available are safe and effective, the morbidity and mortality caused by atherothrombosis are still unacceptably high [33]. Many of these drugs are mostly associated with several side effects [34]. Statin, such as simvastatin, a lipid-lowering agent, known as 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitor, is associated with several side effects, including fever, headache, gastric irritation, myositis, hyperuricaemia, rhabdomyolysis, myalgia, renal and hepatic dysfunctions [35].…”

Section: Traditional Medicationsmentioning

confidence: 99%

Anticoagulants and Hypercoagulability

Kwaifa¹

2022

Anticoagulation - Current Perspectives

View full text Add to dashboard Cite

Anticoagulants are chemical substances that prevent coagulation or prolong the clotting time by suppressing the functions or synthesis of coagulation factors in the blood. Anticoagulation mechanisms are essential in controlling the formation of a blood clot at the site of injury. The abnormalities in the coagulation and fibrinolytic mechanisms could lead to a hypercoagulability state. Inherited hypercoagulable state due, including Factor V Leiden (FVL), prothrombin gene mutation, defective natural proteins that inhibit coagulation, including antithrombin III (ATIII), protein C and S, high levels of FVII, FIX and FXI, are well-documented. Abnormalities of the fibrinolytic system, including tissue-type plasminogen activator (t-PA) and urokinase plasminogen activator (u-PA), and elevated levels of plasminogen activator inhibitor-1 (PAI-1) have been linked to hypercoagulation. Acquired conditions, including certain cancers and their medications, trauma or surgery, pregnancy, obesity and hyperlipidaemia, have been implicated with hypercoagulable events. The clinical symptoms of hypercoagulability can be devastating and may even have lethal outcomes. This activity reviews the principles of anticoagulation, haemostasis, deficiencies associated with hypercoagulability (both coagulation and fibrinolytic disorders), mechanisms of action of some natural-based products with anticoagulant potentials and highlights new clinical and traditional therapeutic strategies to be taken in improving healthcare for patients demanding anticoagulation.

show abstract

Antioxidant, Hepatoprotective and Antiatherogenic Effects of Curcumin on High Fat Diet Induced Dyslipidemia in Rats

Cited by 2 publications

References 28 publications

The effects of high-fat diets composed of different animal and vegetable fat sources on the health status and tissue lipid profiles of male Japanese quail (Coturnix coturnix japonica)

The effects of high-fat diets composed of different animal and vegetable fat sources on the health status and tissue lipid profiles of male Japanese quail (Coturnix coturnix japonica)

Anticoagulants and Hypercoagulability

Contact Info

Product

Resources

About