Antioxidant, Hypolipidemic and Angiotensin Converting Enzyme Inhibitory Effects of Flavonoid-rich Fraction of Hyphaene thebaica (Doum Palm) Fruits on Fat-fed Obese Wistar Rats

Abdulazeez, Mansurah A.; Bashir, Abdelmahmoud Mokhtar; Adoyi, B. S.; Mustapha, Aisha; Kurfi, Binta G.; Usman, Ahmad; Bala, R

doi:10.9734/ajrb/2019/v5i330091

Cited by 8 publications

(7 citation statements)

References 33 publications

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“…However, treatment with H. thebaica extracts significantly (P < 0.05) decreased the total lipids, triglyceride, total cholesterol, and LDL of all treated groups as compared to the diabetic rats. Abdulazeez et al, (2019) and Bayad (2016), reported results similar to the present study.…”

Section: Resultssupporting

confidence: 92%

Hypolipidemic Potential of Ethyl acetate Extract of Hyphaene thebaica Fruit in Streptozotocin-induced Diabetic Rats

Dahiru

Samuel

2022

Trad.Med.J

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Hyperlipidemia is characterized by elevated levels of Triglycerides, Cholesterol, LDL, and decreased levels of HDL are challenges in the management of Diabetes mellitus which might lead to death. This study aimed to determine the hypolipidemic potential of ethyl acetate extract of Hyphaene thebaica fruit in streptozotocin-induced diabetic rats. The hypolipidemic potential of H. thebaica fruit in streptozotocin-induced diabetic rats was determined. Rats were divided into six groups. Treatment groups were administered the extract at doses of 400 and 200 mg/kg body weight. Oral administration of the extract at 400 mg/kg body weight for four weeks significantly (p < 0.05) decreased the levels of total cholesterol (151.7 mg/dl ±2.40), Triglyceride (84.0 mg/dl ±1.15), LDL (75.2 mg/dl ±1.20) and increased HDL (39.3 mg/dl ±1.88) level. However no significant (p < 0.05) difference was observed between the 400 and 200 mg/kg body weight dose. Conclusively, H. thebaica can be used as a medicinal plant due to its protective action against dyslipidemic complications of diabetes mellitus.

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Section: Resultssupporting

confidence: 92%

Hypolipidemic Potential of Ethyl acetate Extract of Hyphaene thebaica Fruit in Streptozotocin-induced Diabetic Rats

Dahiru

Samuel

2022

Trad.Med.J

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“…As well as the aqueous extract of Hyphaene thebaica which possesses an antioxidant activity due to its substantial amount of water-soluble phenolic content. These results are in agreement with other studies [34] [38].…”

Section: Antioxidant Enzymes Activity In Plasmasupporting

confidence: 94%

“…Insulin can activate are act as glucosidase inhibitors, reducing the lipoprotein lipase, the enzyme lipoprotein solver. These results are in agreement with other studies [32] [34].…”

Section: Blood Lipid Profilesupporting

confidence: 94%

“…( Figure 2) It shows that injection of alloxan effect in rats (group 2) caused shrinkage and vacuolizations of some cells in islets of langerhans of both alpha and beta as well as found necrotic in beta Langerhans This may be due to the fact that diabetes affects the lipid metabolism due to insulin deficiency in the body, which leads to necrosis and damage to beta langerhans cells [34]. Treatment of alloxan diabetic rat (group 3) with doum fruit extract (0.5 g/kg b•w) showed the size of islets of langerhans cells was moderate and slight congestion between acinar cells as observed (Figure 3).…”

Section: Histopathological Resultsmentioning

confidence: 99%

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Effect of Doum Fruit (Hyphaene Thebaica) Extract on Some Biochemical Parameters, Enzyme Activities and Histopathological Changes of Pancreas in Alloxan Induced Diabetic Rats

Hassan¹

2020

FNS

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Medicinal plants have been used in the treatment of some diseases like diabetes. One of them is doum fruit extract. The study was conducted to evaluate effect of doum fruit extract on some biochemical parameters, including enzyme activities and histopathological changes of pancreas in alloxan induced diabetic rats. Animals were allocated into five groups of rats, two groups, several as control (one normal and one diabetic rats) and the other three groups were induced diabetic with doum extract (0.5, 1 and 2 g/kg b•wt) which were given every other day by stomach tube for 6 weeks. Evaluation was made for glucose, insulin, lipid profile, enzyme activities, antioxidant activity and histopathological changes of pancreas. The results showed that doum fruit extract decreased blood glucose, insulin, total cholesterol (TC), triglyceride (TG), total lipid (TL), low-density lipoprotein cholesterol (LDL-C), lactate dyhadreygenase (LDH), alanine and aspartate amino transferase (ALT, AST), alkaline phosphatase (ALP) and Malondialdehyde (MDA) while plasma catalase activity and high density lipoprotein cholesterol (HDL-C) were significantly (p < 0.05) increased. Therefore, the results of this study demonstrated that the active compounds present in the doum extract have a positive effect on the biochemical parameters of diabetic rats.

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“…17 HFD was prepared daily and rats were given this diet for 6 weeks until they become obese. 18 Rat obesity was judged indirectly by comparing the weight of HFD-fed to ND-fed rats, and the extract of E. japonica was given for another 6 weeks.…”

Section: Animalsmentioning

confidence: 99%

Ethanol Extracts of Eriobotrya japonica (Loquat) Seeds, Leaves, and Fruits Have Anti-obesity and Hypolipidemic Effects in Rats

Abdelrahman

Bustanji

Abdalla

2022

Pharmacognosy Magazine

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Background: Obesity is a serious public health problem contributing to development of several diseases, including hyperlipidemia, hyperglycemia, and hypertension. The plant Eriobotrya japonica (loquat) has been used in traditional Chinese medicine to treat many ailments and traditional healers used it to reduce weight. Objective: To examine the potential anti-obesity and hypolipidemic effects of ethanol extract of loquat in rats. Materials and Methods: Loquat leaves, fruits, or seeds were extracted with ethanol. About 96 Wistar male rats were fed either a normal rat diet (normal control group; group 1) or a high-fat diet (HFD) for 12 weeks (obese; groups 2−12). Obese rats were divided into11 groups as follows: (obese control: group 2) (obese positive control which received the hypolipidemic reference drug atorvastatin: group 3). Groups (4−6), (7−9), and (10−12) were given seed, leaf, or fruit extract, respectively, at 40,100, and 400 mg/kg. Body weight, serum glucose, lipid profile, creatinine, liver enzymes, albumin, and total protein were measured weekly. Results: HFD consumption significantly increased body weight and serum total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL), very-low density lipoprotein (VLDL), and glucose and decreased HDL compared to rats fed the normal diet. HFD also increased serum glutamic-oxaloacetic transaminase (GOT), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP) and creatinine but decreased serum albumin and total protein. Administration of E. japonica seed, leaf, or fruit extract significantly decreased body weight, TC, TGs, LDL, VLDL, glucose, liver, and renal enzymes but increased HDL, albumin, and total protein levels. Conclusion: E. japonica seed, leaf, and fruit ethanol extract regulates body weight gain, has hypolipidemic properties, and positively affects liver and kidney enzymes.

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Antioxidant, Hypolipidemic and Angiotensin Converting Enzyme Inhibitory Effects of Flavonoid-rich Fraction of Hyphaene thebaica (Doum Palm) Fruits on Fat-fed Obese Wistar Rats

Cited by 8 publications

References 33 publications

Hypolipidemic Potential of Ethyl acetate Extract of Hyphaene thebaica Fruit in Streptozotocin-induced Diabetic Rats

Hypolipidemic Potential of Ethyl acetate Extract of Hyphaene thebaica Fruit in Streptozotocin-induced Diabetic Rats

Effect of Doum Fruit (Hyphaene Thebaica) Extract on Some Biochemical Parameters, Enzyme Activities and Histopathological Changes of Pancreas in Alloxan Induced Diabetic Rats

Ethanol Extracts of Eriobotrya japonica (Loquat) Seeds, Leaves, and Fruits Have Anti-obesity and Hypolipidemic Effects in Rats

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