Antioxidant mediated protective effect of Bridelia tomentosa leaf extract against carbofuran induced oxidative hepatic toxicity

Mondal, Milon; Hossen, Md. Sakib; Rahman, Mohammad Asikur; Saha, Subhas Chandra; Sarkar, Chandan Kumar; Bhoumik, Nikhil Chandra; Kundu, Sukalyan Kumar

doi:10.1016/j.toxrep.2021.07.003

Cited by 15 publications

(11 citation statements)

References 61 publications

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“…Both CoQ10 and silymarin reduced the carbofuran-induced rise in serum creatinine and BUN ( Fig. 2 ), and our results agreed with previous studies [ 44 , 47 ].…”

Section: Discussionsupporting

confidence: 93%

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Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats

Hossain¹,

Suchi²,

Samiha³

et al. 2023

Heliyon

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“…Both CoQ10 and silymarin reduced the carbofuran-induced rise in serum creatinine and BUN ( Fig. 2 ), and our results agreed with previous studies [ 44 , 47 ].…”

Section: Discussionsupporting

confidence: 93%

“…Nonetheless, both CoQ10 and silymarin administration in carbofuran-induced rats reversed the organ-weight reduction. Mondal and his coworker found a similar effect on liver weight in rats treated with carbofuran [ 44 ].…”

Section: Discussionmentioning

confidence: 90%

Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats

Hossain¹,

Suchi²,

Samiha³

et al. 2023

Heliyon

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“…Antioxidant-rich substances including gallic acid, quercetin, baicalin, vitamins and other natural agents are used to protect against environmental pollutants toxicity (Uzun et al 2010; Donmez et al 2019;Tekeli et al 2023). Gallic acid has many properties such as anti-depressant, anti-bacterial, anticancer, antioxidant, and anti-obesity effects (Mondal et al 2021b). Some researchers reported that gallic acid was found to be the most predominant phenolic acid in both mango peel and pulp with phytotoxic and insect growth regulatory activities (Shivashankar and Sumatki 2022).…”

Section: Discussionmentioning

confidence: 99%

Protective role of gallic acid against fenitrothion-induced hepatotoxicity and nephrotoxicity via oxidative stress, histopathological and biochemical alterations

Apaydın

Kalender

Baş

et al. 2023

Preprint

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Fenitrothion (FNT) is a known environmental contaminant used in public health and agriculture. Gallic acid (GA) is a phenolic compound found in numerous plants. This study analyzed the hepatotoxic and nephrotoxic effects of FNT and to evaluate the possible protective effect of gallic acid. FNT (1/25 LD50, 32 mg/kg body weight/day), and gallic acid (50 mg/kg body weight/day) were administrated to male rats by gavage for 28 days. In the present study, the renal (blood urea nitrogen, creatinine and uric acid levels) and liver (albumin, total protein, aspartate aminotransferase, alanine aminotransferase, total cholesterol, triglyceride, lactate dehydrogenase) function markers in the blood, acetylcholinesterase activities, antioxidant enzyme activities and malondialdehyde level as markers of oxidative stress, and histopathological changes were researched in liver and kidney tissues. Additionally, while superoxide dismutase, catalase, glutathione-S-transferase and glutathione peroxidase activities were decreased in the liver and kidney tissue of rats treated with fenitrothion, malondialdehyde level was significantly increased. Histopathological analyses showed many injuries occurred in the renal and hepatic tissue of fenitrothion-treated animals. Also, the supplementation of gallic acid with fenitrothion significantly improved fenitrothion-induced alterations in renal and liver function markers, antioxidant enzyme activities, acetylcholinesterase activities malondialdehyde levels, and histological features of tissues.

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“…This extract appears to have no adverse effects on the body weight of mice which were given three different dosages. Likewise, in humans and other species, relative organ weight can be used to determine various physiological and pathological states [ 74 ]. Toxicants cause unexpected metabolic responses in the body's major organs [ 75 ].…”

Section: Discussionmentioning

confidence: 99%

Subchronic Toxicity Study of Alternanthera philoxeroides in Swiss Albino Mice Having Antioxidant and Anticoagulant Activities

Khandker

Uddin

Shapla

et al. 2022

Journal of Toxicology

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Alternanthera philoxeroides, a tropical herb and edible vegetable, has been popular as a medicinal plant. Applying in vitro approach, we initially attempted to assess the phytochemicals, bioactive chemicals, as well as antioxidant and anticoagulant activities of this plant. Following that, the in vivo toxicological effects of methanolic extracts of A. philoxeroides using different doses on the kidney, heart, lung, liver, stomach, brain, and blood of female Swiss Albino mice were investigated. We estimated phytochemicals content as well as antioxidant activity through DPPH, NO, CUPRAC, and reducing power assays, followed by the anticoagulant activities of PT and aPTT and bioactive compounds using HPLC. To confirm the biocompatibility of A. philoxeroides extracts, histopathological and hematological parameters were examined in a mice model. Total phenol, flavonoid, and tannin content in A. philoxeroides was 181.75 ± 2.47 mg/g, 101.5 ± 3 .53 mg/g, and 68.58 ± 0.80 mg/g, respectively. Furthermore, the HPLC study confirmed the presence of four phenolic compounds: catechin, tannic acid, gallic acid, and vanillic acid. The methanolic extract of A. philoxeroides showed considerable antioxidant activity in all four antioxidant assay methods when compared to the standard. In comparison to ascorbic acid, A. philoxeroides also demonstrated a minor concentration-dependent ferric and cupric reduction activity. In vivo evaluation indicated that A. philoxeroides extracts (doses: 250, 500, and 1000 mg/kg) had no negative effects on the relative organ or body weight, or hematological indicators. Our study concluded that A. philoxeroides had significant antioxidant and anticoagulant activities and demonstrated no negative effects on the body or relative organ weight, histopathological, and hematological indices in the mouse model.

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Antioxidant mediated protective effect of Bridelia tomentosa leaf extract against carbofuran induced oxidative hepatic toxicity

Abstract: Graphical abstract

Cited by 15 publications

References 61 publications

Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats

Coenzyme Q10 ameliorates carbofuran induced hepatotoxicity and nephrotoxicity in wister rats

Protective role of gallic acid against fenitrothion-induced hepatotoxicity and nephrotoxicity via oxidative stress, histopathological and biochemical alterations

Subchronic Toxicity Study of Alternanthera philoxeroides in Swiss Albino Mice Having Antioxidant and Anticoagulant Activities

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