Antioxidant phenolic compounds from seeds of Hordeum vulgare Linn. ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats

Mahajan, Renuka; Prasad, Shilpa; Gaikwad, S.S.; Itankar, Prakash R.

doi:10.1016/j.jtcms.2023.06.010

Cited by 4 publications

(8 citation statements)

References 22 publications

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“…Regular monitoring of blood sugar and kidney function through urine or blood tests is crucial for early detection and intervention to prevent or slow CKD progression. Certain polyphenols might improve insulin sensitivity, leading to better blood sugar control and reducing the workload on the kidneys [ 79 , 80 , 81 ]; modulate enzymes involved in carbohydrate metabolism, potentially helping to regulate blood sugar levels [ 82 , 83 ]; and may reduce the risk factors for type 2 diabetes by protecting against glucolipotoxicity-induced damage [ 84 ], helping prevent diabetic nephropathy [ 85 , 86 , 87 , 88 , 89 ].…”

Section: Discussionmentioning

confidence: 99%

“…Epicatechin [88] ↓ BUN, total cholesterol, and triglycerides ↓ MDA ↑ SOD, GSH, and catalyze Regeneration of tubular epithelium, inhibition of necrosis and hemorrhages, and recovery of atrophic glomeruli [88] Gallic acid, catechin and derivatives, and rutin and derivatives [70] ↓ systolic and mean arterial BP ↑ plasma and urinary nitrite and nitrate [92] Gallic acid, catechin and derivatives, and rutin and derivatives [70] Recovery in the kidney morphology [93] Table 1. Cont.…”

Section: Compound Reported Bioactivitymentioning

confidence: 99%

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Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Baptista,

Paié-Ribeiro,

Almeida

et al. 2024

Molecules

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Chronic kidney disease (CKD) presents a formidable global health concern, affecting one in six adults over 25. This review explores the potential of phenolic compounds in managing CKD and its complications. By examining the existing research, we highlight their diverse biological activities and potential to combat CKD-related issues. We analyze the nutritional benefits, bioavailability, and safety profile of these compounds. While the clinical evidence is promising, preclinical studies offer valuable insights into underlying mechanisms, optimal dosages, and potential side effects. Further research is crucial to validate the therapeutic efficacy of phenolic compounds for CKD. We advocate for continued exploration of their innovative applications in food, pharmaceuticals, and nutraceuticals. This review aims to catalyze the scientific community's efforts to leverage phenolic compounds against CKD-related challenges.

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Section: Discussionmentioning

confidence: 99%

Section: Compound Reported Bioactivitymentioning

confidence: 99%

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Baptista,

Paié-Ribeiro,

Almeida

et al. 2024

Molecules

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“…Barley ( Hordeum vulgare L.) sprouts, which are rich in bioactive compounds, have attracted attention for their potential health benefits such as anti-obesity effects, anti-inflammatory effects, antioxidative activity, and preventive effects against alcohol-induced liver injury [ 3 , 4 , 5 , 6 ]. Barley has high concentrations of dietary fibers, minerals, flavonoids, and phenolic acids [ 7 , 8 , 9 ]. Among the known phenolic acids and flavonoids found in barley are saponarins and lutonarins [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Effects of Barley Sprout Fermented by Lactic Acid Bacteria in RAW264.7 Macrophages and Caco-2 Cells

Kim,

Shim,

Kim

et al. 2024

Foods

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The anti-inflammatory effects of supernatants produced from sprouted barley inoculated with Lactiplantibacillus plantarum KCTC3104 (Lp), Leuconostoc mesenteroides KCTC3530 (Lm), Latilactobacillus curvatus KCTC3767 (Lc), or a mixture of these lactic acid bacteria were investigated using RAW264.7 macrophages. BLp and BLc, the lyophilized supernatants of fermented sprouted barley inoculated with Lp and Lc, respectively, effectively reduced the nitric oxide (NO) levels hypersecreted by lipopolysaccharide (LPS)-stimulated RAW264.7 and LPS-stimulated Caco-2 cells. BLp and BLc effectively reduced the NO levels in LPS-stimulated RAW264.7 macrophages, and these effects tended to be concentration-dependent. BLc and BLp also exhibited strong DPPH radical scavenging activity and immunostimulatory effects. BLp and BLc significantly suppressed the levels of NO and pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 in LPS-stimulated RAW264.7 macrophages and LPS-stimulated Caco-2 cells, indicating their anti-inflammatory effects. These effects were greater than those of unfermented barley sprout (Bs). The functional components of Bs, BLp, and BLc were analyzed by HPLC, and it was found that lutonarin and saponarin were significantly increased in the fermented sprouted barley sample inoculated with Lp and Lc (BLp and BLc).

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“…Barley (Hordeum vulgare) is a plant that is well known for its high content and variety of flavonoids [14,15]. It is the fourth most popular grain crop worldwide [16]. It has high concentrations of dietary fibers, minerals, flavonoids, and phenolic acids [16].…”

Section: Introductionmentioning

confidence: 99%

“…It is the fourth most popular grain crop worldwide [16]. It has high concentrations of dietary fibers, minerals, flavonoids, and phenolic acids [16]. Proanthocyanidins, catechins, saponarins, and lutonarins are some of the known phenolic acids and flavonoids found in barley, respectively [15,16].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the contents of total polyphenol, total flavonoid, and flavonoid derivatives in unfermented and fermented barley sprouts

Uy,

Lee,

Byun

et al. 2023

JABC

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Barley (Hordeum vulgare) belongs to the Poaceae family. This study compared the polyphenol and flavonoid levels of unfermented and fermented barley sprouts using spectrophotometric assays. The findings indicated that fermentation greatly boosted the flavonoid content but caused only a slight increase in the polyphenol content. However, this does not imply that fermentation has no effects whatsoever on the polyphenol content of barley sprouts. This was due to the fact that some flavonoids cannot be detected by the wavelength used to calculate the overall polyphenol concentration. Both samples were subjected to high-performance liquid chromatography analysis and detected the flavonoids lutonarin, saponarin, isoorientin, isovitexin, and tricin-all of which have bioactive properties-most notably known for their antioxidant activity. These results augment the ongoing phytochemical profiling research and can possibly valorize the already thriving barley industry.

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Antioxidant phenolic compounds from seeds of Hordeum vulgare Linn. ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats

Cited by 4 publications

References 22 publications

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Anti-Inflammatory Effects of Barley Sprout Fermented by Lactic Acid Bacteria in RAW264.7 Macrophages and Caco-2 Cells

Comparison of the contents of total polyphenol, total flavonoid, and flavonoid derivatives in unfermented and fermented barley sprouts

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