Antioxidant plants and diabetes mellitus

Nasri, Hamid; Shirzad, Hedayatollah; Baradaran, Azar; Rafieian-Kopaei, Mahmoud

doi:10.4103/1735-1995.163977

Cited by 88 publications

(45 citation statements)

References 127 publications

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“…The reactive oxygen species are known to deteriorate the cellular physiology of nerve cells and ultimate lead to neurodegenerative disorders. Polyphenols, flavonoids and vitamin E present in the CP plant act as reactive oxygen species (ROS) scavengers and also ameliorate the lipid peroxidation, thereby attributing towards the anti-oxidant activity of CP (Nasri et al, 2015). It has also been observed that the ethyl acetate and methanolic extract of CP have shown appreciable results (IC 50~0 .07 mg/mL and 0.075 mg/mL, respectively), as observed in 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.…”

Section: Anti-oxidant Activitymentioning

confidence: 99%

Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies

Balkrishna¹,

Thakur²,

Varshney³

2020

Front. Pharmacol.

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Convolvulus prostratus Forssk., a nootropic herb used in traditional medicinal systems, is also frequently known by its taxonomic synonym Convolvulus pluricaulis. In Indian medicinal system-Ayurvedait is named as Shankhpushpi. According to the ancient literature, this herb has been attributed with several therapeutic properties, such as anxiolytic, neuroprotective, antioxidant, analgesic, immunomodulatory, antimicrobial, antidiabetic and cardioprotective activities. This medicinal herb has been reported to contain many bioactive phytoconstituents, such as, alkaloid (convolamine), flavonoid (kaempferol) and phenolics (scopoletin, b-sitosterol and ceryl alcohol), that have been ascribed to the observed medicinal properties. Several research teams across the globe have highlighted the neuro-pharmacological profile of C. prostratus, wherein, the neuroprotective, nootropic and neuro-modulatory roles have been described. Besides, role of C. prostratus extracts in neurodegeneration has been well demonstrated. Despite of such elaborative preclinical pharmacological profile, detailed clinical investigations and mechanistic mode-of-action studies of this important herb are yet to be executed. The present review is attempted to showcase the phytochemical profile, pharmacological attributes and medicinal information of C. prostratus; with comprehensive research gap analysis. It is hoped that the scientific update on the ethnomedicinal aspects of this herb would thrive research propagation and development of the CNS phytopharmaceuticals, originated from C. prostratus.

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Section: Anti-oxidant Activitymentioning

confidence: 99%

Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies

Balkrishna¹,

Thakur²,

Varshney³

2020

Front. Pharmacol.

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Section: Introductionmentioning

confidence: 99%

“…The oxidative modification hypothesis of atherosclerosis predicts that LDL‐C particles must be oxidized before they become a contributing factor for atherosclerosis . LDL‐C particles oxidation and retention in the subendothelial space of blood vessel is considered to be the initiating factor of atherosclerotic lesion development . Thus, in the development of a new novel antihyperlipidmic agent, an important area of interest is to search for an agent with antioxidant activity that will protect endothelial and myocardial functions and may serve as a better anti‐atherosclerotic agent.…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Evaluation of Novel Isonicotinic Carboxamide Derivatives as Potential Anti‐Hyperlipidemic and Antioxidant Agents

Farha

Bustanji

Al‐Hiari

et al. 2017

Archiv der Pharmazie

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Hyperlipidemia and oxidative stress have been implicated as contributing factors to the development of atherosclerosis and cardiovascular diseases (CVDs). Currently, a large number of antihyperlipidemic medications are conveniently available in the market. Nonetheless, the majority of antihyperlipidemics lack the desired safety and efficacy. Thus, the present study was undertaken to evaluate the potential effect of novel N-(benzoylphenyl)pyridine-4-carboxamide and N-(9,10-dioxo-9,10-dihydroanthracenyl)pyridine-4-carboxamide derivatives in controlling hyperlipidemia and oxidative stress using the Triton WR-1339-induced hyperlipidemic rat model for antihyperlipidemic activity and the DPPH radical scavenging assay for antioxidant activity. This study revealed the antihyperlipidemic activities of some of the newly synthesized, novel carboxamide derivatives, mainly C4 and C12 (p < 0.05). The majority of the compounds displayed a relatively low or no DPPH radical scavenging effect, with C20 possessing the best radical scavenging effect (22%) among all. This research opens the door for new potential antihyperlipidemic compounds derived from isonicotinic acid. N-(3-Benzoylphenyl)pyridine-4-carboxamide (C4) was found to have promising lipid-lowering and antioxidant effects, which may create a protective effect against CVDs, by reducing the LDL-C levels and diminishing the generation of reactive oxygen species.

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“…It is a multifactorial, inflammatory disease that affect the walls of blood vessels and determine major changes of features and function of platelets. A diet high in saturated fat, hypercholesterolemia, obesity, dyslipidaemia, hyperglycemia, insulin resistance, hypertension, dysfunction of nitric oxide, and smoking habit are key players in atherosclerosis occurrence [13,14]. All these factors are also actively involved in the development of major cardiovascular diseases (coronary diseases, stroke, heart failure, peripheral vascular disease) [15,16].The aim of this study was to investigate of the impact of some risk factors for atherosclerosis on the antiplatelet effect of clopidogrel in patients with acute coronary syndrome and the possible correlation with metabolizer phenotype of patients based on CYP2C19 polymorfisms.…”

mentioning

confidence: 99%

Is There a Link Between Clopidogrel Resistance and Common Risk Factors for Atherosclerosis in Patients with Acute Coronary Syndrome?

Costache¹,

Mitu²,

Namat³

et al. 2017

Rev. Chim.

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The antiplatelet effect of clopidogrel prodrug is characterized by a wide inter-individual variability that has a significant clinical relevance. Among varios factors that are involved in the occurrence of clopidogrel resistance, the genetic polymorphisms play a key role. The aim of the present study was to investigate the impact of some risk factors for atherosclerosis on the antiplatelet effect of clopidogrel in patients with acute coronary syndrome and the possible correlation with metabolizer phenotype of patients based on CYP2C19 polymorfisms. We found a statistically significant correlation (p value [ 0.05) between smoking or dyslipidaemia and the presence of ultrarapid metabolizer phenotype for clopidogrel in our research population.

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Antioxidant plants and diabetes mellitus

Cited by 88 publications

References 127 publications

Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies

Phytochemical Profile, Pharmacological Attributes and Medicinal Properties of Convolvulus prostratus – A Cognitive Enhancer Herb for the Management of Neurodegenerative Etiologies

Pharmacological Evaluation of Novel Isonicotinic Carboxamide Derivatives as Potential Anti‐Hyperlipidemic and Antioxidant Agents

Is There a Link Between Clopidogrel Resistance and Common Risk Factors for Atherosclerosis in Patients with Acute Coronary Syndrome?

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