Antioxidant potential of barley extract in rats subjected to a high-fat diet

Zimmermann, Alice Mesquita; Rivero, Alessandra Coelho; Bezerra, Aline Sobreira; Ruviaro, Amanda Roggia; Novack, Mariana Moura Ercolani; Nörnberg, José Laerte

doi:10.1590/s0101-20612013005000024

Cited by 6 publications

(4 citation statements)

References 23 publications

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“…The data of the present study suggest a greater VLDL oxidation and greater liver lipid peroxidation susceptibilities in D group, both associated with the consumption of hypercholesterolemic diet and the diabetic induction [ 9 , 50 , 51 ]. However, animals consuming CFE-RM showed reduction in VLDL and liver oxidations, as a consequence of the marked antioxidant properties of proanthocyanidins [ 52 ].…”

Section: Discussionmentioning

confidence: 86%

Can Carob-Fruit-Extract-Enriched Meat Improve the Lipoprotein Profile, VLDL-Oxidation, and LDL Receptor Levels Induced by an Atherogenic Diet in STZ-NAD-Diabetic Rats?

et al. 2019

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Carob fruit extract (CFE) has shown remarkable in vitro antioxidant properties and reduces postprandial hyperglycemia and hyperlipidemia in healthy animals. Development of functional meat products that contain bioactive components are presented as a great nutritional strategy. Until now, the effect of the consumption of restructured meat enriched with CFE in a murine model of diabetes has not been investigated. The objective of this study was to evaluate the effect on glycemia, lipemia, lipoprotein profile, Ldlr, arylesterase (AE), and very low-density lipoproteins (VLDL) and liver oxidation in streptozotocin-nicotinamide (STZ-NAD) growing Wistar diabetic rats fed restructured meat in the frame of a high cholesterol/high saturated-fat diet. In the present study, three groups (D, ED and DE) were fed cholesterol-enriched (1.4% cholesterol and 0.2% cholic acid) and high saturated-fat diets (50% of total energy from fats and 20.4% from saturated fatty acids). Rats were subjected to a STZ-NAD administration at the 3rd week. Group D did not receive CFE, while ED and DE rat groups received CFE before and after the diabetic induction, respectively. After eight weeks, D rats showed hyperglycemia and hypercholesterolemia, an increased amount cholesterol-enriched VLDL (β-VLDL), IDL and LDL particles and triglyceride-enriched HDL. ED and DE partially blocked the hypercholesterolemic induction with respect to D group (p < 0.001) and improved glycemia, cholesterol levels, lipoprotein profile, Ldlr, plasma AE activity and liver oxidation (p < 0.001). Fecal fat, moisture and excretion were higher while dietary digestibility was lower in ED and DE vs. D counterparts (p < 0.0014). In conclusion, CFE-enriched meat shows, for the first time, hypoglycemic and hypolipidemic effects in STZ-NAD animals fed high cholesterol/high saturated-fat diets. Likewise, it manages to reverse possible diabetes lipoprotein alterations if CFE-enriched meat is consumed before pathology development or improves said modifications if Type 2 Diabetes Mellitus is already established.

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Section: Discussionmentioning

confidence: 86%

Can Carob-Fruit-Extract-Enriched Meat Improve the Lipoprotein Profile, VLDL-Oxidation, and LDL Receptor Levels Induced by an Atherogenic Diet in STZ-NAD-Diabetic Rats?

et al. 2019

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“…Notably, oxidative capacity was improved in association with restrained inflammatory stress. Importantly, it has been reported that barley exerts hypolipidic impacts (El Rabey, Al‐Seeni, & Amer, ; Zimmerman et al, ) owing to its high content of β‐glucans, which quench the excess reactive oxygen species and attenuate the expression of TNF‐α (Oliveira et al, ). Beyond its antioxidant activity, Delaney et al () discussed the antiatherogenic activity of β‐glucans that mechanistically reduce total cholesterol (TC).…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation of barley and/or dates attenuate hypercholesterolemic‐induced endometrial dysfunction in Wistar albino rats via alleviation of apoptotic pathways and enhancing oxidative capacity

et al. 2019

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Our study was conducted to characterize the efficacy of barley and/or date palm fruits (10%) in alleviation of hypercholesterolemic endometrial insults in obese rat model. Sixty‐four Wistar albino rats were randomized into eight groups (n = 8); control, hypercholesterolemic‐ and hypercholesterolemic‐treated groups. Animals were subjected to treatment for 4 months. After sacrifice, serum and uterine tissues were collected and processed for biochemical, histological, immunohistochemical, and electron microscopic investigations. In hypercholesterolemic rats, the endometrium displayed hyperplasia with necrotic patches in the surface epithelium and its glandular lining cells. Also, there was a remarkable increase in the endometrial thickness and significant decrease in corresponding glandular numbers. Prompted by these findings, immunohistochemical localization revealed that expression of proliferating cell nuclear antigen was downregulated, while cleaved caspase‐3 was upregulated in the endometrial cells in hypercholesterolemic group. Accordingly, there was remarkable depletion of antioxidant enzymatic activities associated with increased lipid peroxidation and apoptotic markers. Contradictory, supplementation of barley and/or dates to hypercholesterolemic groups showed intriguing amelioration for the histological architecture of the endometrium and balancing its oxidative redox. In conclusion, the administration of barley and/or dates confers enhanced synergistic effects in attenuation of hypercholesterolemic induced‐endometrial dysfunction. This is clear evidence that endometrial amelioration was directly linked to the implication of highly potential antioxidant capacity of barley and/or dates phytochemicals, β‐glucan, polyphenols, and other trace elements, which can be utilized to establish a phyto‐therapeutic strategy for activating endometrial cell regeneration. Practical applications Barley and dates confer both hypoglycemic and hypocholesterolemic potentials. Therefore, their ingredients would be implicated in the amelioration of uterine functions in obese women. These favorable potentials were directly linked to the restraining of endometrial inflammation and retrieving the oxidative capacity. Furthermore, our findings demonstrated that barley and dates substantially diminished the expression of TNF‐α, mitigated DNA damage and prevented leukocytic infiltration in the endometrial tissue; based on their high content of dietary phytochemicals, β‐glucan, polyphenols, and other trace elements.

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“…In this study, a higher level of TPC was found in ethanol extract may be attributable the complex formation of some phenolic compounds in the extract that is soluble in ethanol whereby these phenolic compounds may possess more phenol groups. Aof Hordeum vulgare L.antioxidant studies has been demonstrated in many studies (Anwar et al, 2010;Zimmermann et al, 2013;Oh et al, 2014) where barley contains much more signi icant amounts of phenolic compound (0.2 -0.4%) than other cereal grains which composed of polyphenols, phenolic acids, proanthocyanidins (PAs) and catechins (Quinde et al, 2004).…”

Section: Total Phenolic Content and Antioxidant Activitymentioning

confidence: 99%

The Effect of Hordeum Vulgare L. Extracts on Blood Cholesterol Level and Lipid Peroxidation Activity in a Hypercholesterolemia Rodent Model

Chyang¹,

Mawaddah²

2020

ijrps

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Hordeum vulgare L. (Barley) is an ancient and essential cereal grain crop with the claim that it has the potential to reduce cholesterol level and to lower oxidation activity in the liver.However, it hasn’t been proven scientifically. Hence,this study was conducted to investigate the total phenolic content (TPC), total antioxidant activity (TAC) and liver peroxidation activity of barley aqueous and ethanol extractas well as assess the effect of ethanol extract on cholesterol level of high-fat diet rats. TAC of barley extract was determined by using ABTS (2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt) assay andDPPH (2,2-diphenyl-1-picrylhydrazyl radical) assay. Meanwhile, Total Phenolic Content TPCwas determined by Folin-Ciocalteu assay. Atotal of 15 Sprague Dawley rats were tested for the lowering cholesterol properties in barley and its association with lipid peroxidation product (Melondialdhyhe level) by adding the barley into their daily diet. The result indicated that TAC and TPC value of ethanol barley extract was high. Barley ethanol extracts effectively lowering cholesterol level in Sprague Dawley rats. Meanwhile, the malondialdehyde level in the liver tissue was a significant difference between the high-fat diet group of rats and the high-fat diet group of rats treated with ethanol barley extract. Conclusion, ethanol barley extract possess more phenolic content, antioxidant component and reducing cholesterol level of high-fat diet rats.

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Antioxidant potential of barley extract in rats subjected to a high-fat diet

Cited by 6 publications

References 23 publications

Can Carob-Fruit-Extract-Enriched Meat Improve the Lipoprotein Profile, VLDL-Oxidation, and LDL Receptor Levels Induced by an Atherogenic Diet in STZ-NAD-Diabetic Rats?

Can Carob-Fruit-Extract-Enriched Meat Improve the Lipoprotein Profile, VLDL-Oxidation, and LDL Receptor Levels Induced by an Atherogenic Diet in STZ-NAD-Diabetic Rats?

Dietary supplementation of barley and/or dates attenuate hypercholesterolemic‐induced endometrial dysfunction in Wistar albino rats via alleviation of apoptotic pathways and enhancing oxidative capacity

The Effect of Hordeum Vulgare L. Extracts on Blood Cholesterol Level and Lipid Peroxidation Activity in a Hypercholesterolemia Rodent Model

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