Antioxidant Potential of Piperidine Containing Compounds-a Short Review

Abstract

Piperidine is a saturated heterocyclic ring, considered as a privileged scaffold in view of its role in wide range of biological activities. Piperidine is good candidate molecule for obtaining potent antioxidant agents. The planar nature of this heterocyclic nucleus allows the introduction of substituent groups at different positions on the ring. In the present review, the antioxidant profile of piperidine containing compounds has been focused. The compounds were classified into naturally occurring piperidines, unsaturated piperidines, N-substituted piperidines, piperamides, piperanols, piperidine oximes, and hydrazides.

Synthesis, In Vitro Biological Evaluation and Molecular Modeling of Benzimidazole-Based Pyrrole/Piperidine Hybrids Derivatives as Potential Anti-Alzheimer Agents

“…Piperidine and its derivatives have great biological significance in medicinal chemistry and are widely used in the development of drugs for the treatment of various diseases. Their unique chemical properties and ability to interact with a variety of biological targets make them important scaffolds for drug design [ 23 ], including anti-cancer drugs [ 24 , 25 , 26 , 27 , 28 ], antibiotics [ 29 ], analgesics [ 30 ], antidepressants [ 31 ] and antioxidants [ 32 ]. Keeping in view the biological significance of benzimidazole, pyrrole and piperidine moieties, in this study, we designed and synthesized hybrid scaffolds of benzimidazole-bearing pyrroles and piperidines as potential inhibitors of AChE and BuChE for the treatment of Alzheimer’s disease in the search for lead molecules, and the results obtained corroborated that these compounds could be considered as potential lead molecules for the development of improved AChE and BuChE inhibitors.…”