Antioxidant properties and quantitative UPLC-MS/MS analysis of phenolic compounds in dandelion (Taraxacum officinale) root extracts

Kenny, Owen; Smyth, Thomas J.; Hewage, Chandralal M.; Brunton, Nigel P.

doi:10.5530/fra.2014.1.9

Cited by 28 publications

(35 citation statements)

References 21 publications

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“…Dandelion has potential health benefits due to the presence of phenolics, flavonoids, coumarins, terpenoids, sesquiterpene lactones, carotenoids, chlorophylls, dietary fiber, and alkaloids (Colle et al, 2012;Gonzalez-Castejon, Visioli, & Rodriguez-Casado, 2012;Schutz & Schieber 2006). Among flavonoids, apigenin-7-Oglycoside, luteolin-7-O-glycoside, and naringenin-7-O-glycoside were identified and furthered analyzed for their antimicrobial and antioxidant activities (Kenny et al, 2015;Kenny, Smyth, Hewage, & Brunton, 2014). According to USDA national nutrient database, dandelion leaf contains 1.9 g of dietary fiber per cup compared to kale that has 0.6 g. The importance of dietary fiber is vast, but it has significant role in bile acid binding capacity.…”

Section: Introductionmentioning

confidence: 99%

Identification and Quantification of Phytochemicals, Antioxidant Activity, and Bile Acid‐Binding Capacity of Garnet Stem Dandelion (Taraxacum officinale)

Gomez

Singh

Acharya

2018

Journal of Food Science

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Section: Introductionmentioning

confidence: 99%

Identification and Quantification of Phytochemicals, Antioxidant Activity, and Bile Acid‐Binding Capacity of Garnet Stem Dandelion (Taraxacum officinale)

Gomez

Singh

Acharya

2018

Journal of Food Science

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“…The antioxidant and total phenolic content of the crude ethyl acetate extract and 16 NP fractions were measured using in vitro antioxidant assays, and the result is shown in Table . The DPPH Trolox ® equivalent (TE) value of the crude ethyl acetate extract (295.481 ± 0.955 mg TE g −1 extract) was stronger than that of the sequentially derived ethyl acetate extract (227.728 ± 11.849 mg TE g −1 extract) reported by Kenny et al ., . The resulting NP fractions showed varying levels of antioxidant activity and phenolic content.…”

Section: Resultsmentioning

confidence: 99%

“…Kenny et al . () previously stated that the ethyl acetate extract from dandelion root was shown to possess high antioxidant activity coupled to high phenolic content. Further investigation of known phenolic compounds in this extract, quantified by UPLC‐MS/MS, revealed that chlorogenic acid was in high abundance (31.059 mg g −1 extract) and was most likely responsible for the majority of the observed antioxidant activity (Kenny et al ., ).…”

Section: Resultsmentioning

confidence: 99%

Quantitative UPLC‐MS/MS analysis of chlorogenic acid derivatives in antioxidant fractionates from dandelion (Taraxacum officinale) root

Kenny

Smyth

Hewage³

et al. 2014

Int J of Food Sci Tech

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Summary While qualitative studies have identified chlorogenic acids in antioxidant extracts, particularly ethyl acetate‐derived extracts, of Taraxacum officinale, quantitative analysis of these phenolic compounds remains largely unreported for this species. In this study, bioactivity‐guided fractionation of an antioxidant crude ethyl acetate extract (DPPH = 295.481 ± 0.955 mg TE g−1 extract) from T. officinale root resulted in a number of reverse‐phase fractions that demonstrated high antioxidant activity (DPPH = 1058.733–1312.136 mg TE g−1 extract), stronger than that of the synthetic antioxidant Trolox®. UPLC‐MS/MS screening of these fractions for the presence of selected mono‐ and di‐caffeoylquinic acids revealed large quantities of 1,5‐dicaffeoylquinic acid present in several fractions (853.052–907.324 μg mg−1), respectively. Due to the antioxidant potency and high levels of 1,5‐dicaffeoylquinic acid observed in these fractions, it was concluded that specifically this chlorogenic acid derivative is a major contributor to the antioxidant efficacy of dandelion root.

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“…Other studies using liquid chromatography with (photo) diode array detection (LC-DAD) indicated that the concentration in leaf extracts amounts to 0.85 mg/g, with 0.22% dry weight (Dw); HPLC-UV analysis showed concentrations to be 8 mg/g in leaf extracts. LC-DAD analysis indicated CRA at 0.09-0.51% Dw in roots and 0.77% Dw in the leaves [55][56][57][58]. According to Owen et al (2014), CGA is a potent anti-oxidant because of its high phenolic content, with an ethyl acetate chromatographic fraction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) IC 50 (0.033 ± mg/ml) [55].…”

Section: Chlorogenic and Chicoric Acidmentioning

confidence: 99%

“…LC-DAD analysis indicated CRA at 0.09-0.51% Dw in roots and 0.77% Dw in the leaves [55][56][57][58]. According to Owen et al (2014), CGA is a potent anti-oxidant because of its high phenolic content, with an ethyl acetate chromatographic fraction of 2,2-diphenyl-1-picrylhydrazyl (DPPH) IC 50 (0.033 ± mg/ml) [55].…”

Section: Chlorogenic and Chicoric Acidmentioning

confidence: 99%

The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes

2016

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■ AbstractThe tremendous rise in the economic burden of type 2 diabetes (T2D) has prompted a search for alternative and less expensive medicines. Dandelion offers a compelling profile of bioactive components with potential anti-diabetic properties. The Taraxacum genus from the Asteraceae family is found in the temperate zone of the Northern hemisphere. It is available in several areas around the world. In many countries, it is used as food and in some countries as therapeutics for the control and treatment of T2D. The anti-diabetic properties of dandelion are attributed to bioactive chemical components; these include chicoric acid, taraxasterol (TS), chlorogenic acid, and sesquiterpene lactones. Studies have outlined the useful pharmacological profile of dandelion for the treatment of an array of diseases, although little attention has been paid to the effects of its bioactive components on T2D to date. This review recapitulates previous work on dandelion and its potential for the treatment and prevention of T2D, highlighting its anti-diabetic properties, the structures of its chemical components, and their potential mechanisms of action in T2D. Although initial research appears promising, data on the cellular impact of dandelion are limited, necessitating further work on clonal β-cell lines (INS-1E), α-cell lines, and human skeletal cell lines for better identification of the active components that could be of use in the control and treatment of T2D. In fact, extensive invitro, in-vivo, and clinical research is required to investigate further the pharmacological, physiological, and biochemical mechanisms underlying the effects of dandelion-derived compounds on T2D.

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Antioxidant properties and quantitative UPLC-MS/MS analysis of phenolic compounds in dandelion (Taraxacum officinale) root extracts

Cited by 28 publications

References 21 publications

Identification and Quantification of Phytochemicals, Antioxidant Activity, and Bile Acid‐Binding Capacity of Garnet Stem Dandelion (Taraxacum officinale)

Identification and Quantification of Phytochemicals, Antioxidant Activity, and Bile Acid‐Binding Capacity of Garnet Stem Dandelion (Taraxacum officinale)

Quantitative UPLC‐MS/MS analysis of chlorogenic acid derivatives in antioxidant fractionates from dandelion (Taraxacum officinale) root

The Physiological Effects of Dandelion (Taraxacum Officinale) in Type 2 Diabetes

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