Antioxidant properties of Korean black raspberry wines and their apoptotic effects on cancer cells

Jung, Jongwan; Son, Mi-Young; Jung, Seungwon; Nam, Pil-Woo; Sung, Jung-Suk; Lee, Seung-Joo; Lee, Kwang‐Geun

doi:10.1002/jsfa.3540

Cited by 26 publications

(15 citation statements)

References 31 publications

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“…Recently, based on the information of health beneficial effects of bokbunja, the growth area and the harvest quantity in South Korea have rapidly increased resulting in various bokbunja products, such as juices and concentrates, rice cakes, vinegar, and dietary supplements. Several studies have shown that bokbunja fruit and wine are positively related with various physiological functions, including antioxidative , anti-inflammatory (Lim, Hwang, & Shin, 2012;Yang et al, 2007), anticancer (Jung et al, 2009), anti-high cholesterol (Lee et al, 2015), and prevention of the memory impairment (Choi, Lee et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the phenolic composition and antioxidant activity of Korean black raspberry, Bokbunja, (Rubus coreanusMiquel) with those of six other berries

Yang

Choi

2016

CyTA - Journal of Food

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Bokbunja (Rubus coreanus Miquel) and six other berries were analyzed for physico-chemical properties and antioxidant activities, using four different methods (DPPH • , ABTS •+ , FRAP, and reducing power). The total polyphenol, total flavonoid, and total anthocyanin contents of bokbunja were significantly higher than those of other berries, followed by mulberry, blackberry, cranberry, raspberry, wild strawberry, and strawberry. Antioxidant activity assays also showed that bokbunja's antioxidant activity exceeded that of the other berries. Bokbunja had not only significantly higher levels of kaempferol, quercetin, and ellagic acid but also the highest ellagic acid content (408.57 mg kg −1 fresh weight). The potential antioxidant activities of bokbunja might be ascribed to its high total polyphenol, total flavonoid, and total anthocyanin contents. Ellagic acid may also affect antioxidant activity, although the concentrations of other phenolic compounds such as kaempferol, quercetin, and quercetin-3-O-rutinoside were high in other berries such as blackberry, cranberry, and mulberry.Comparación de la composición fenólica y la actividad antioxidante de la frambuesa negra coreana Bokbunja, (Rubus coreanus Miquel) con otros seis tipos de frutos del bosque RESUMEN Se analizaron la bokbunja (Rubus coreanus Miquel) y otros seis frutos del bosque para determinar sus propiedades fisicoquímicas y su actividad antioxidante utilizando cuatro métodos diferentes (DPPH • , ABTS •+ , FRAP y poder reductor). El contenido total de polifenoles, flavonoides y antocianina de la bokbunja fue significativamente más alto que aquel de otros frutos del bosque, seguido por el de las moras de Morus, las moras de Rubus, los arándanos rojos, las frambuesas, las fresas silvestres y las fresas. Los ensayos de actividad antioxidante mostraron también que la actividad antioxidante de la bokbunja excedió a aquella de los otros frutos del bosque. La bokbunja no solamente obtuvo unos niveles significativamente más altos de kaempferol, quercetina y ácido elágico, sino que también el mayor contenido de ácido elágico (408.57 mg kg −1 peso fresco). La potencial actividad antioxidante de la bokbunja podría ser atribuida a sus alto contenido total de polifenoles, flavonoides y antocianina. El ácido elágico también podría afectar a la actividad antioxidante, aunque las concentraciones de otros compuestos fenólicos como el kaempferol, la quercetina y la quercetina-3-O-rutinósido fueron más altas en otros frutos del bosque como las moras de Rubus, los arándanos rojos y las moras de Morus. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Comparison of the phenolic composition and antioxidant activity of Korean black raspberry, Bokbunja, (Rubus coreanusMiquel) with those of six other berries

Yang

Choi

2016

CyTA - Journal of Food

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“…[6][7][8][9] These RCM constituents have been shown to exert diverse functional effects, including anti-osteoporosis, anti-inflammation, and anti-carcinogenesis. 10,11) Anti-carcinogenic functions of RCM are suggested to act partly by inducing DNA damage, 12) activating apoptosis, 13) and reducing angiogenesis. 14) Sanguiin H-6 extracted from RCM has been shown to decrease angiogenesis in endothelial cells via the inhibition of vascular endothelial growth factor receptor-ligand binding.…”

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Unripe Rubus coreanus Miquel suppresses migration and invasion of human prostate cancer cells by reducing matrix metalloproteinase expression

Kim

Lee

Kim

2014

Bioscience, Biotechnology, and Biochemistry

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Rubus coreanus Miquel (RCM) is used to promote prostate health and has been shown to have anti-oxidant and anti-carcinogenic activities. However, the effects and mechanisms of RCM on prostate cancer metastasis remain unclear. PC-3 and DU 145 cells were treated with ethanol or water extract of unripe or ripe RCM and examined for cell invasion, migration, and matrix metalloproteinases (MMPs) activity and expression. Phosphoinositide 3-kinase (PI3K) and Akt activities were examined. Unripe RCM extracts exerted significant inhibitory effects on cell migration, invasion, and MMPs activities. A significant reduction in MMPs activities by unripe RCM ethanol extract treatment (UE) was associated with reduction of MMPs expression and induction of tissue inhibitors of metalloproteinases (TIMPs) expression. Furthermore, PI3K/Akt activity was diminished by UE treatment. In this study, we demonstrated that UE decreased metastatic potential of prostate cancer cells by reducing MMPs expression through the suppression of PI3K/Akt phosphorylation, thereby decreasing MMP activity and enhancing TIMPs expression.

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“…Liu 그러나 국내산 나무딸기류에 대한 선행 연구들은 과일이 나 씨앗의 일반성분과 화학적 특성만을 분석하였으며, 항산 화능과 생리활성에 대해서는 일반적으로 보급되는 소수의 품종에 한정되어 수행되었다 (7,9,14). 본 연구에서는 국내에 서 재배한 다섯 종류의 나무딸기류 과일의 추출에 있어서 씨앗성분의 혼입이 항산화 성분 및 항산화능에 미치는 영향 을 분석하고, in vitro 모델을 이용하여 각 추출물의 NO 소거 능(RAW264.7)과 암세포(HT-29, KATO …”

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Antioxidant and Anti-Proliferative Activities of Rubus Fruits in Korea

Jung¹,

Lee²,

Cho³

et al. 2012

Journal of the Korean Society of Food Science and Nutrition

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This study was conducted to determine the polyphenols, flavonoids and antioxidant activity (FRAP) of the extracts (crushed by hand or a homogenizer) of Rubus fruits (blackberry, Korean raspberry, black raspberry, boysenberry and golden raspberry) produced in Korea. In addition, their nitric oxide (NO) scavenging activity in RAW 264.7 cells and anti-proliferative activity in HT-29 and KATO-3 cells were investigated. Polyphenol and flavonoid contents in the Rubus fruits ranged from 0.6 to 8.9 and from 0.1 to 7.9 mg/g fresh fruit, respectively. Black raspberry had the highest polyphenol and flavonoid contents among the Rubus fruits. The homogenized extracts of blackberry, Korean raspberry and golden raspberry fruits showed significantly higher polyphenol and FRAP values than the hand-crushed extracts. FRAP values of the Rubus fruit extracts were significantly correlated with their polyphenol (R=0.995) and flavonoid (R=0.967) contents. The Rubus fruit extracts suppressed the NO secretions in LPS-treated RAW264.7 cells. There were no significant differences between extracts obtained by crushing by hand and those obtained using a homogenizer. Proliferation rates of HT-29 and KATO-3 cancer cells treated with the Rubus fruit extracts at 0.1, 0.25 and 0.5 mg/mL were reduced by 3～32% and 0～57%, respectively. The homogenized extracts of blackberry and Korean raspberry fruits had significantly higher anti-proliferation activity against HT-29 cancer cells than the hand-crushed extracts. However, extraction method did not show any significant difference on proliferation of KATO-3 cancer cells.

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Antioxidant properties of Korean black raspberry wines and their apoptotic effects on cancer cells

Cited by 26 publications

References 31 publications

Comparison of the phenolic composition and antioxidant activity of Korean black raspberry, Bokbunja, (Rubus coreanusMiquel) with those of six other berries

Comparison of the phenolic composition and antioxidant activity of Korean black raspberry, Bokbunja, (Rubus coreanusMiquel) with those of six other berries

Unripe Rubus coreanus Miquel suppresses migration and invasion of human prostate cancer cells by reducing matrix metalloproteinase expression

Antioxidant and Anti-Proliferative Activities of Rubus Fruits in Korea

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