Antioxidant properties of yeast (1→3)-β--glucan studied by electron paramagnetic resonance spectroscopy and its activity in the adjuvant arthritis

Kogan, Grigorij; Staško, Andrej; Bauerová, Katarína; Polovka, Martin; Šoltés, Ladislav; Brezová, Vlasta; Navarová, Jana; Mihalová, Danica

doi:10.1016/j.carbpol.2005.02.010

Cited by 100 publications

(70 citation statements)

References 52 publications

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“…As resulted also from our previous experiments (Bauerova et al, 2005a, 2005b, 2008a, 2008bDrafi et al, 2010;Jancinova et al, 2009;Kogan et al, 2005;Macickova et al, 2010;Ponist et al, 2010;Sotnikova et al, 2009;Strosova et al, 2008Strosova et al, , 2009), all performed in the AA model, substances with antioxidant properties have a high potency to be used in therapy of RA. They decreased the progression of AA when administered to rats with AA over the period of 28 days.…”

Section: Newer Experimental Therapies With Antioxidants Evaluated In Aasupporting

confidence: 59%

“…In our AA experiments, enzyme linked immunosorbent assay (ELISA) was used most frequently for quantitative determination of protein carbonyls in plasma (Buss et al, 1997). The first measurement of protein carbonyls in our experiments with AA was performed in a study with carboxymethyl (1/3)-b-D-glucan isolated from Saccharomyces cerevisiae administered to arthritic rats (Kogan et al, 2005). In this study, the content of carbonyls in the arthritic animals increased significantly in comparison with healthy controls and protein carbonyl determination in plasma was performed according to the method described by (Levine et al, 1990) and modified in agreement with the previously applied experimental conditions .…”

Section: Adjuvant Arthritis: An Animal Model For Preclinical Evaluatimentioning

confidence: 99%

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Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Bauerová¹,

Poništ²,

Nosáľ³

et al. 2012

Rheumatoid Arthritis - Treatment

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Section: Newer Experimental Therapies With Antioxidants Evaluated In Aasupporting

confidence: 59%

Section: Adjuvant Arthritis: An Animal Model For Preclinical Evaluatimentioning

confidence: 99%

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Bauerová¹,

Poništ²,

Nosáľ³

et al. 2012

Rheumatoid Arthritis - Treatment

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“…S. cerevisiae have antioxidant compounds in the cytoplasm, mitochondria, and on the entire surface of the cell [30]. In addition, one of its cell wall structural polymers (1-3), (1-6)-b-D-glucan) has antioxidant [31] and immunomodulatory activities [32]. Therefore, this organism can be used to measure the antioxidant action of a wide variety of organic and inorganic substances.…”

Section: In Vivo Antioxidant Activitymentioning

confidence: 99%

Preparation of phytol-loaded nanoemulsion and screening for antioxidant capacity

Islam

Streck²,

Paz³

et al. 2016

Int Arch Med

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The study prepared a nanoemulsion with a diterpenoid isoprenoid alcohol called phytol (PYT) and subsequently tested it for antioxidant capacity. For this, PYT-loaded nanoemulsion was prepared by phase inversion method and both PYT-containing nanoemulsion (PNE) and PYT-free nanoemulsion (PFNE) (2-16 µM) were tested for antiradical activity (DPPH•: 1,1-dipheny-picrylhydrazyl radical; ABTS•+: azino-bisethylbenzthiazoline-sulfonic acid; •OH: hydroxyl radical scavenging; NO•: nitrite oxide radical), lipid peroxidation (LP), reduction potential (RP), and inhibition of hemolysis (HL) in rat erythrocytes in comparison with an α-tocopherol analogue (Trolox -TRO -positive control). In addition, an in vivo test was performed with wildtype and deficient Saccharomyces cerevisiae strains using hydrogen peroxide (H 2 O 2 ) as a stressor. Results suggest that PNE exhibited higher antioxidant than the PFNE. Increasing doses reveled antioxidant capacity in a dose-dependent manner. In the S. cerevisiae study, both PFNEand PNE-treated groups exhibited decreased rates of survival with the highest doses, whichever in the presence of stressor increased the survival rates, which indicates antioxidative defense capacity of PYT. In this occasion, PNE exhibited prominent antioxidative defense in the presence of stressor rather than PFNE. In conclusion, PYT exhibited potential antioxidant activity but at high concentration it was toxic to the yeast cells. The production of PYT-nanoemulsions may be relevant to the pharmaceutical sciences.

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“…Studies conducted over the past decade have shown that -glucans inhibit tumor development [28,38], enhance defense against bacterial infection [15,24], activate macrophages [8], induce production of cytokines [10,34], nitric oxide (NO) and arachidonic acid metabolites [14,21], increase hematopoiesis [35], exert radioprotective effects [12], are effective against burns [9,37], improve wound healing by inducing the macrophage release of wound growth factors [40] and lower serum lipids [4,23]. Among the several mechanisms proposed for the protective effects of -glucans, the major one is related to antioxidant capacity of the molecules [1,20], which has been further proven by Kogan et al [16] using electron paramagnetic response spectroscopy.…”

mentioning

confidence: 99%

Hepatoprotective Effects of Paramylon, a .BETA.-1,3-D-Glucan Isolated from Euglena gracilis Z, on Acute Liver Injury Induced by Carbon Tetrachloride in Rats

Sugiyama

Suzuki²,

Mitra³

et al. 2009

J. Vet. Med. Sci.

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ABSTRACT. Paramylon is a -(1-3)-D-glucan isolated from Euglena gracilis Z. This study was designed to evaluate the protective effects of paramylon on liver injury induced by carbon tetrachloride (CCl 4 ) in rats. Wistar stain male rats were orally administered paramylon (500, 1,000 and 2,000 mg/kg body weight) before treatment with a single intraperitoneal dose of 50% CCl 4 (2 ml/kg body weight). The rats were sacrificed 24 hr later, and blood samples were collected for assay of serum biochemical parameters. The livers were excised to evaluate the activity of antioxidant enzymes. Histopathological examination of the livers was also performed. The results showed that the treatment of paramylon prevented elevation of the serum levels of hepatic enzyme markers and inhibited fatty degeneration and hepatic necrosis induced by CCl 4 . Pre-administration of paramylon reduced the liver apoptotic index. The treatment of paramylon recovered reductions of activity of hepatic superoxide dismutase, catalase and glutathione peroxidase induced by CCl 4 . These results demonstrate that paramylon exhibits protective action on acute hepatic injury induced by CCl 4 via an antioxidative mechanism. To the best of our knowledge, this is the first report of a hepatoprotective effect based on the antioxidative action of paramylon.

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Antioxidant properties of yeast (1→3)-β--glucan studied by electron paramagnetic resonance spectroscopy and its activity in the adjuvant arthritis

Cited by 100 publications

References 52 publications

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Preparation of phytol-loaded nanoemulsion and screening for antioxidant capacity

Hepatoprotective Effects of Paramylon, a .BETA.-1,3-D-Glucan Isolated from Euglena gracilis Z, on Acute Liver Injury Induced by Carbon Tetrachloride in Rats

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