Antioxidant protection of gallic acid against toxicity induced by Pb in blood, liver and kidney of rats

Abstract

The effect of the antioxidant gallic acid (GA) on Pb toxicity in blood, liver and kidney was investigated in the present study. Rats Wistar received Pb nitrate (50 mg/Kg/day, i.p., 5 days) followed by GA (13.5 mg/Kg, p.o., 3 days) or a chelating agent (EDTA, 55 mg/Kg, i.p.). As result, Pb decreased body weight, hematocrit and blood δ-aminolevulinic acid dehydratase (ALA-D) activity. In addition, high Pb levels were observed in blood and tissues, together with increased (1) lipid peroxidation in erythrocytes, plasma and tissues, (2) protein oxidation in tissues and (3) plasma aspartate transaminase (AST) levels. These changes were accompanied by decreasing in antioxidant defenses, like superoxide dismutase (SOD) activity in tissues and catalase (CAT) activity and reduced glutathione (GSH) in liver. GA was able to reverse Pb-induced decrease in body weight and ALA-D activity, as well as Pb-induced oxidative damages and most antioxidant alterations, however it did not decrease Pb bioaccumulation herein as EDTA did. Furthermore, EDTA did not show antioxidant protection in Pb-treated animals as GA did. In conclusion, GA decreased Pb-induced oxidative damages not by decreasing Pb bioaccumulation, but by improving antioxidant defenses, thus GA may be promising in the treatment of Pb intoxications.

The Hepatoprotective Effect of Gallic Acid on Mercuric Chloride-Induced Liver Damage in Rats

“…The results of our study showed that the antioxidant attributes may be accountable for the liver protective effects of GA. This finding is in compliance with earlier surveys, showing that GA protects the cells via reducing the generation of free radicals (39,47,50,51).…”

“…The hydroxyl group in the para form to the carboxylic group can particularly affect the antioxidant activity of GA (50). The results of our study showed that the antioxidant attributes may be accountable for the liver protective effects of GA.…”

Outcomes of Gallic Acid on Alternariol Induced Cyto-Morphic and Genotoxic In Vivo Changes in Parotid Gland: 4-HNE Incorporated

“…Marino et al [53] reported GA scavenging efficiency as compared to melatonin, sesamol, protocatechuic acid and capsaicin. In accordance with our results, Reckziegel et al [54] and Ghaznavi, et al [55] confirmed GA-induced elevated levels of SOD and CAT, which reported substantial improvement after GA treatment. The observable amelioration of AOH-induced inflammatory cellular infiltrations in GA group suggests its anti-inflammatory properties.…”

A Comprehensive Review on the Phytoconstituents from Six Species of the Genus Amaranthus

“…Flavonoids: Four flavonoidal phytoconstituents like Gallic acid (57), Caffeic acid (58), Rutin (59), and Quercetin (60) were also isolated from A. caudatus (Figure 9) (Paranthaman et al, 2012;Reckziegel et al, 2016;Zhao et al, 2014).…”