Antioxidant protection of Malaysian tualang honey in pancreas of normal and streptozotocin-induced diabetic rats

Erejuwa, Omotayo O.; Sulaiman, Siti Amrah; Wahab, Mohd Suhaimi Abdul; Sirajudeen, K. N. S.; Salleh, Salzihan Md; Gurtu, Sunil

doi:10.1016/j.ando.2010.03.003

Cited by 107 publications

(103 citation statements)

References 33 publications

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“…Our finding was also supported by previous animal studies that showed restoration of CAT activity in the erythrocytes of young and middle-aged rats [17], pancreas of diabetic rats [18], and liver of male BALB/c mice administered trichlorfon [19] following honey supplementation.…”

Section: Discussionsupporting

confidence: 80%

Tualang Honey Supplementation Reduces Blood Oxidative Stress Levels/Activities in Postmenopausal Women

Shafin

Othman

Zakaria

et al. 2014

ISRN Oxidative Medicine

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This study aimed to investigate the ability of Tualang honey (TH), a phytoestrogen, to reduce blood oxidative stress levels/activities in postmenopausal women and compared the effects with the standard estrogen progestin therapy (EPT). A total of 78 healthy postmenopausal women were randomly assigned to one of two groups; EPT group received Femoston conti 1/5 (1 mg 17 -estradiol and 5 mg dydrogesterone), and TH group, received 20 g of TH supplement daily for 16 weeks. The reduced glutathione to oxidized glutathione ratio (GSH : GSSG), plasma glutathione peroxidase (GPx), catalase (CAT), superoxide dismutase (SOD), and 4-hydroxynonenal (4-HNE) levels/activities were measured at pre-and postinterventions using commercially available kits. The plasma GPx and CAT activities were notably increased, and plasma 4-HNE level was significantly decreased in postmenopausal women who received EPT and TH supplementation. TH supplementation for 16 weeks was able to reduce blood oxidative stress levels/activities of postmenopausal women comparable to those who received EPT. Thus, TH has a potential to be used as antioxidant therapy to combat oxidative stress-induced neurodegenerative diseases. This trial is registered with NCT01300676.

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Section: Discussionsupporting

confidence: 80%

Tualang Honey Supplementation Reduces Blood Oxidative Stress Levels/Activities in Postmenopausal Women

Shafin

Othman

Zakaria

et al. 2014

ISRN Oxidative Medicine

View full text Add to dashboard Cite

show abstract

“…Other studies have also demonstrated that honey is able to increase antioxidant enzymes levels and ameliorate oxidative stress in plasma and other tissues such as renal and pancreas [61][62][63][64][65][66][67][68]. It is suggested that the aforementioned flavonoids contents and enzymatic and non-enzymatic substances in honey are responsible for its antioxidative effects.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

Azman

Zakaria

Othman

et al. 2018

Journal of Taibah University for Science

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The neuroprotective effects of Tualang honey in stress-induced young and aged rats were investigated. Tualang honey (200 mg/kg body weight) was administered for 28 days. Stressinduced rats were subjected to loud noise 100 dB(A) 4 hours daily for 14 days. Stress exposure significantly induced memory impairment, increased brain oxidation indices, and decreased antioxidant enzymes activities and neuronal density in mPFC, CA2 and CA3 hippocampal areas in both young and aged rats. The stressed rats treated with Tualang honey showed a significant decrease in stress hormone levels and brain oxidation indices, and increase in memory, antioxidant enzymes activities, and neuronal density in mPFC and hippocampus compared to the vehicle-treated stressed rats. The protective effect of Tualang honey was more prominent in young than aged rats. These results suggest the neuroprotective effects of Tualang honey against oxidative stress and memory decline due to stress exposure and/or ageing through its antioxidant property. ARTICLE HISTORY

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“…It was found that tualang honey exerts a hypoglycemic effect and ameliorates oxidative stress in kidneys of streptozotocininduced diabetic rats [79]. Another study [80] suggested that hypoglycemic effect of tualang honey in streptozotocin (STZ)-induced diabetic rats might be attributed to its antioxidative effect on the pancreas. Moreover, combination of honey with metformin or glibenclamide might offer additional antioxidant effect to these drugs.…”

Section: Diabetesmentioning

confidence: 99%

Honey between Traditional Uses and Recent Medicine

2012

Maced J Med Sci

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From ancient times, honey was not only used as a natural sweetener but also as a healing agent. Many health-promoting and curative properties attributed to it are the basis for some traditional folk medicine treatments throughout the world today.Its beneficial effects in different disorders, rediscovered in recent decades , varying from its antibacterial effects and benefits in wound healing to its safe role in peptic ulcer, gastroenteritis, oncology, ophthalmology, dermatology and dental hygiene. This will be discussed in this review on the basis of a series of scientific studies conducted to investigate the therapeutic properties of this natural product.

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Antioxidant protection of Malaysian tualang honey in pancreas of normal and streptozotocin-induced diabetic rats

Cited by 107 publications

References 33 publications

Tualang Honey Supplementation Reduces Blood Oxidative Stress Levels/Activities in Postmenopausal Women

Tualang Honey Supplementation Reduces Blood Oxidative Stress Levels/Activities in Postmenopausal Women

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

Honey between Traditional Uses and Recent Medicine

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