Tualang Honey Supplementation Reduces Blood Oxidative Stress Levels/Activities in Postmenopausal Women

Shafin, Nazlahshaniza; Othman, Zahiruddin; Zakaria, Rahimah; Hussain, Nik Hazlina Nik

doi:10.1155/2014/364836

Cited by 21 publications

(23 citation statements)

References 26 publications

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“…In this study, although the differences among the experimental groups were not significant, the midbrain CAT activity was lower in group PQ and was higher in the two groups that received Tualang honey (groups TH and PQ + TH) than in the control group (N). Increased CAT activity following honey supplementation has previously been reported in animal [54] and human disease models [55, 56]. …”

Section: Discussionmentioning

confidence: 91%

Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure

Tang

Salam

Jaafar

et al. 2017

Oxidative Medicine and Cellular Longevity

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Paraquat (PQ) is a dopaminergic neurotoxin and a well-known pneumotoxicant that exerts its toxic effect via oxidative stress-mediated cellular injuries. This study investigated the protective effects of Tualang honey against PQ-induced toxicity in the midbrain and lungs of rats. The rats were orally treated with distilled water (2 mL/kg/day), Tualang honey (1.0 g/kg/day), or ubiquinol (0.2 g/kg/day) throughout the experimental period. Two weeks after the respective treatments, the rats were injected intraperitoneally with saline (1 mL/kg/week) or PQ (10 mg/kg/week) once per week for four consecutive weeks. After four weekly exposures to PQ, the glutathione peroxidase activity and the number of tyrosine-hydroxylase immunopositive neurons in the midbrain were significantly decreased in animals from group PQ (p < 0.05). The lungs of animals from group PQ showed significantly decreased activity of superoxide dismutase and glutathione-S-transferase. Treatment with Tualang honey ameliorated the toxic effects observed in the midbrain and lungs. The beneficial effects of Tualang honey were comparable to those of ubiquinol, which was used as a positive control. These findings suggest that treatment with Tualang honey may protect against PQ-induced toxicity in the rat midbrain and lung.

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Section: Discussionmentioning

confidence: 91%

Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure

Tang

Salam

Jaafar

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…Other studies have also demonstrated that honey is able to increase antioxidant enzymes levels and ameliorate oxidative stress in plasma and other tissues such as renal and pancreas [61][62][63][64][65][66][67][68]. It is suggested that the aforementioned flavonoids contents and enzymatic and non-enzymatic substances in honey are responsible for its antioxidative effects.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

Azman

Zakaria

Othman

et al. 2018

Journal of Taibah University for Science

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The neuroprotective effects of Tualang honey in stress-induced young and aged rats were investigated. Tualang honey (200 mg/kg body weight) was administered for 28 days. Stressinduced rats were subjected to loud noise 100 dB(A) 4 hours daily for 14 days. Stress exposure significantly induced memory impairment, increased brain oxidation indices, and decreased antioxidant enzymes activities and neuronal density in mPFC, CA2 and CA3 hippocampal areas in both young and aged rats. The stressed rats treated with Tualang honey showed a significant decrease in stress hormone levels and brain oxidation indices, and increase in memory, antioxidant enzymes activities, and neuronal density in mPFC and hippocampus compared to the vehicle-treated stressed rats. The protective effect of Tualang honey was more prominent in young than aged rats. These results suggest the neuroprotective effects of Tualang honey against oxidative stress and memory decline due to stress exposure and/or ageing through its antioxidant property. ARTICLE HISTORY

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“…This observation could be due to the antioxidant effects of Tualang honey which cause reduction in the number of free radicals. This explanation is based on several published data that reported Tualang honey as an effective antioxidant in reducing the MDA levels in human subjects and animal models [ 17 , 47 ].…”

Section: Discussionmentioning

confidence: 99%

Tualang Honey Protects against BPA-Induced Morphological Abnormalities and Disruption of ERα, ERβ, and C3 mRNA and Protein Expressions in the Uterus of Rats

Zaid

Kassim

Othman

2015

Evidence-Based Complementary and Alternative Medicine

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Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) that can disrupt the normal functions of the reproductive system. The objective of the study is to investigate the potential protective effects of Tualang honey against BPA-induced uterine toxicity in pubertal rats. The rats were administered with BPA by oral gavage over a period of six weeks. Uterine toxicity in BPA-exposed rats was determined by the degree of the morphological abnormalities, increased lipid peroxidation, and dysregulated expression and distribution of ERα, ERβ, and C3 as compared to the control rats. Concurrent treatment of rats with BPA and Tualang honey significantly improved the uterine morphological abnormalities, reduced lipid peroxidation, and normalized ERα, ERβ, and C3 expressions and distribution. There were no abnormal changes observed in rats treated with Tualang honey alone, comparable with the control rats. In conclusion, Tualang honey has potential roles in protecting the uterus from BPA-induced toxicity, possibly accounted for by its phytochemical properties.

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Tualang Honey Supplementation Reduces Blood Oxidative Stress Levels/Activities in Postmenopausal Women

Cited by 21 publications

References 26 publications

Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure

Tualang Honey Protects the Rat Midbrain and Lung against Repeated Paraquat Exposure

Neuroprotective effects of Tualang honey against oxidative stress and memory decline in young and aged rats exposed to noise stress

Tualang Honey Protects against BPA-Induced Morphological Abnormalities and Disruption of ERα, ERβ, and C3 mRNA and Protein Expressions in the Uterus of Rats

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