Antioxidant response and oxidative damage in brain cortex after high dose of pilocarpine

Tejada, Silvia; Sureda, Antoni; Roca, C.; Gamundı́, Antoni; Esteban, Susana

doi:10.1016/j.brainresbull.2006.10.005

Cited by 90 publications

(62 citation statements)

References 27 publications

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“…Moreover, the use of pergolide in association with L-DOPA in the treatment of Parkinson's disease has shown the powerful antioxidant effect of this combination as compared with the administration of L-DOPA alone [17,18]. When it comes to pilocarpine (its effect on oxidative stress has been studied mostly in experimental models of epilepsy), it was observed an increase of specific activity of catalase in the hippocampus, prefrontal cortex, and striatum [19,20] and lowering the level of malondialdehyde [21]. Clonidine has been found to exert antioxidant effects as demonstrated in various experimental situations, such as some models of addiction to cocaine [22] or hyperglycemia [23] in which the administration of clonidine improved the oxidative stress status.…”

Section: Discussionmentioning

confidence: 99%

The interactions between the cholinergic and catecholaminergic systems - focusing on memory and oxidative stress

Ciobîcă¹,

Lefter²,

Stoica³

2017

Fiziol Zh

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Section: Discussionmentioning

confidence: 99%

The interactions between the cholinergic and catecholaminergic systems - focusing on memory and oxidative stress

Ciobîcă¹,

Lefter²,

Stoica³

2017

Fiziol Zh

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“…An increase was also observed in catalase and superoxide dismutase activities, two important antioxidant enzymes. Furthermore, these authors also reported that pilocarpine induces oxidative damage, and increases antioxidant enzyme activities and expression in the brain cortex, leading to excitotoxicity and cell death [20]. In the model of Data represent means ± S.E.M of the number of animals in parentheses.…”

Section: Discussionmentioning

confidence: 99%

Evidence for Excitatory and Inhibitory Amino Acids Participation in the Neuropharmacological Activity of Alpha- and Beta-Amyrin Acetate

Aragão¹,

Carneiro²,

Juniora³

et al. 2009

TOPHARMJ

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Abstract:We evaluated the neuropharmacological profile of acetylated alpha-and beta-amyrin (AcAMY) obtained by the acetylation of the isomeric mixture of alpha-and beta-amyrin isolated from Protium heptaphyllum. Male Swiss mice were administered with AcAMY (2.5, 5, 10 and 25 mg/kg, i.p.), and anticonvulsant (pentylenetrazole-and pilocarpine-induced convulsions), sedative (barbiturate-induced sleep and open field tests) and anxiolytic (elevated plus maze test) activities were studied. Results showed that AcAMY administered intraperitoneally or orally, protected the animals against pentylenetetrazole-but not against pilocarpine-induced convulsions. The drug increased both the latency to the 1 st convulsion and the latency to death. The barbiturate-induced sleeping time was also increased, as well as the ethyl ether-induced sleeping time, confirming the sedative nature of AcAMY. The acute administration of AcAMY also produced an anxiolytic effect. After the sub-chronic administration, both sedative and anxiolytic effects were manifested, at the two higher doses. Amino acids measurements in brain areas of mice treated with AcAMY (25 mg/kg, i.p., for 7 days) showed an 89% increase in tyrosine levels, in the hippocampus. In the striatum, tyrosine and taurine were increased by 97 and 79%, respectively, while decreases in the levels of aspartate, GABA and glutamate of 72, 55 and 60%, respectively were observed. In conclusion, our results showed that AcAMY presents sedative, anxiolytic and anticonvulsant properties. Although the drug mechanism of action is not completely clarified, it seems to involve a decrease in excitatory amino acids and an increase of inhibitory amino acids. Furthermore, the GABAergic system may also play a role.

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“…Causes of increases to effect of SOD contribute to render superoxide groups harmless. [26,27] Researchers have observed contradictory results in the levels of SOD, either in acute or chronic models. [28][29][30] SOD is one of the major antioxidants.…”

Section: Discussionmentioning

confidence: 99%

Presentation to Affirmative Effect of Doxcycyline in pentylene tetrazole induced Seizures models

Erbaş¹,

Çelik²,

Cinar³

et al. 2014

Epilepsi

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Amaç: Daha önce yapılan çalışmalarda enflamasyonun epilepsi patogeneziyle olan ilişkisi gösterilmiştir, buna göre oksidatif stresin de epilepsi patogeneziyle ilişkili olabileceği düşünülebilir. Literatürde doksisiklinin hem antienflamatuvar hem de antioksidan etkilerini inceleyen çalışmalar bulunmaktadır. Bu çalışmanın amacı doksisiklinin muhtemel antikonvulzan etkilerini elektroensefelografi kayıtları (EEG), laboratuvar bulguları ve davranışsal bulgular eşliğinde incelemektir. Gereç ve Yöntem:Otuz altı sıçan rastgele iki gruba ayrıldı. Grup A EEG kayıtları, Group B ise davranışsal değişikliklerin incelenmesi için belirlendi. 35 mg/kg pentilentetrazol (PTZ) EEG kayıtları için, 70 mg/kg PTZ davranışsal değişiklikler oluşturmak için kullanıldı. Davranışsal değişikliklerin değerlendirilmesinde ilk miyoklonik jerk zamanı ve Racine konvulziyon skalası kullanıldı, EEG kayıtlarının değerlendirilmesinde ise spike yüzdeleri kullanıldı. Bulgular:Yapılan istatistiksel analiz sonucunda doksisiklin verilen gruplarda spike yüzdeleri, ilk miyoklonik jerk zamanları ve Racine konvulziyon skoları açısından doksisiklinin olumlu etkileri tespit edildi. Ayrıca çalışmamızda doksisiklin verilen grupta malonedialdehit seviyeleri düşmüşken, süperoksitdismutaz seviyelerinin artmış olduğu görüldü.Sonuç: Sunulan çalışmada doksisiklinin PTZ indükte konvulziyonlar üzerine olumlu etkileri olduğu görülmüştür, bu etkisini de antienflamatuvar ve nöroprotektif özellikler yoluyla olabileceğini düşünmekteyiz. SummaryObjectives: There were some experimental and clinical evidence that inflammation in the brain is likely to predispose epileptogenesis. Also, it is thought to be that oxidative stress can play a role in epilepsy. Both laboratory and clinical studies have demonstrated the antiinflammatory-antioxidant properties of doxycycline. We aimed to highlight the anticonvulsant action of doxycycline based on clinical, laboratory and EEG findings in animal models. Methods: 36 rats were randomly divided in two groups. Group A for EEG recordings and Group B for behavioral assesment. 35 mg/kg pentylene tetrazole (PTZ) used for EEG recording and 70 mg/kg PTZ used for behavioral evaulations. For behavioral evaluations we assessed first myoclonic jerk time (FMJ) and Racine convulsion scores (RCS). Results:The groups were evaluated according to EEG records and severety of seizures. It was found to be doxcycyline is effective both on the time of the first myoclonic jerk' (FMJ) latency and Racine convulsion scale (RCS) scores. Besides, doxcycyline significantly decreased to the percentage of spikes on electroencephalography (EEG) records. Also In current study, it was detected that Malone dialdehit (MDA) levels decreased and superoxide dismutase (SOD) activity increased in doxcycyline-treated groups. Conclusion:In our study, we evaluated that the anticonvulsant effects of doxycycline showed a dose dependent protective effect against PTZ-induced seizures in rats by its anti-inflammatory and neuroprotective properties.

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Antioxidant response and oxidative damage in brain cortex after high dose of pilocarpine

Cited by 90 publications

References 27 publications

The interactions between the cholinergic and catecholaminergic systems - focusing on memory and oxidative stress

The interactions between the cholinergic and catecholaminergic systems - focusing on memory and oxidative stress

Evidence for Excitatory and Inhibitory Amino Acids Participation in the Neuropharmacological Activity of Alpha- and Beta-Amyrin Acetate

Presentation to Affirmative Effect of Doxcycyline in pentylene tetrazole induced Seizures models

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