Antioxidant status in women who have had a miscarriage

Omeljaniuk, Wioleta Justyna; Socha, Katarzyna; Borawska, Maria H.; Charkiewicz, Angelika Edyta; Laudański, T; Kulikowski, M; Kobylec, Edward

doi:10.1016/j.advms.2015.06.003

Cited by 35 publications

(24 citation statements)

References 36 publications

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“…The concentrations of serum trace elements are reported in the literature for the partial elements investigated, but there are some significant differences in content when compared to analogous studies [17,18,19,20]. In our study, the concentrations of serum Fe, Cu, Zn, Se, Sr, and Mn were 131.5 (55–265.0) μg/dL, 195.5 (107–362.4) μg/dL, 74.0 (51–111.0) μg/dL, 72.2 (39–111.6) μg/L, 45.9 (23–104.3) μg/L, and 2.4 (1.2–8.4) μg/L, respectively, which are in agreement with values reported in some of the previous literature [21,22], but were lower or higher when compared to those reported in other studies [23,24,25,26]. As regards the discrepancy, possible reasons include different environmental factors, different socioeconomic status, different dietary patterns, different lifestyles, and racial differences.…”

Section: Discussionsupporting

confidence: 91%

Reference Values of 14 Serum Trace Elements for Pregnant Chinese Women: A Cross-Sectional Study in the China Nutrition and Health Survey 2010–2012

et al. 2017

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The development of reference values of trace elements is recognized as a fundamental prerequisite for the assessment of trace element nutritional status and health risks. In this study, a total of 1400 pregnant women aged 27.0 ± 4.5 years were randomly selected from the China Nutrition and Health Survey 2010–2012 (CNHS 2010–2012). The concentrations of 14 serum trace elements were determined by high-resolution inductively coupled plasma mass spectrometry. Reference values were calculated covering the central 95% reference intervals (P2.5–P97.5) after excluding outliers by Dixon’s test. The overall reference values of serum trace elements were 131.5 (55.8-265.0 μg/dL for iron (Fe), 195.5 (107.0–362.4) μg/dL for copper (Cu), 74.0 (51.8–111.3) μg/dL for zinc (Zn), 22.3 (14.0–62.0) μg/dL for rubidium (Rb), 72.2 (39.9–111.6) μg/L for selenium (Se), 45.9 (23.8-104.3) μg/L for strontium (Sr), 1.8 (1.2–3.6) μg/L for molybdenum (Mo), 2.4 (1.2–8.4) μg/L for manganese (Mn), 1.9 (0.6–9.0) ng/L for lead (Pb), 1.1 (0.3-5.6) ng/L for arsenic (As), 835.6 (219.8–4287.7) ng/L for chromium (Cr), 337.9 (57.0–1130.0) ng/L for cobalt (Co), 193.2 (23.6–2323.1) ng/L for vanadium (V), and 133.7 (72.1–595.1) ng/L for cadmium (Cd). Furthermore, some significant differences in serum trace element reference values were observed between different groupings of age intervals, residences, anthropometric status, and duration of pregnancy. We found that serum Fe, Zn, and Se concentrations significantly decreased, whereas serum Cu, Sr, and Co concentrations elevated progressively compared with reference values of 14 serum trace elements in pregnant Chinese women. The reference values of serum trace elements established could play a key role in the following nutritional status and health risk assessment.

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Section: Discussionsupporting

confidence: 91%

Reference Values of 14 Serum Trace Elements for Pregnant Chinese Women: A Cross-Sectional Study in the China Nutrition and Health Survey 2010–2012

et al. 2017

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“…Our study showed that the totalantioxidant capacity was significantly higher among women with uncomplicated pregnancy when compared to women with EPL. Similar results were seen in other studies where the antioxidant capacity was lower among women who had a first trimester miscarriage than that of healthy women in their first trimester pregnancy [19].…”

Section: Discussionsupporting

confidence: 91%

The Utility of Plasma Transthyretin and Antioxidants as aBiomarker of Early Pregnancy Loss - A Pilot Study

Sen

Goenka

Jha

et al. 2019

Obs Gyne Reivew J Obstet Gynecol

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Objective: Miscarriage or early pregnancy loss (EPL) affects about 15-25% of all pregnancies and is considered as one of the most common complications of the human reproduction. The objective of this pilot study was to quantify and compare the levels of plasma Transthyretin (TTR) and total antioxidant capacity (TAC)among EPL patients and normal pregnant women. Design: Cross sectional pilot study. Subjects: Patients diagnosed with EPL in their first trimester (Incomplete and Missed abortion) and medically terminated pregnancy (MTP) and pregnant women in their first trimester of pregnancy without any complications. Methods: Plasma TTR and total antioxidantcapacity were quantified using Enzyme Linked Immunosorbent Assay (ELISA) and Trolox equivalent antioxidant capacity assay respectively. Statistical analyses were performed with SPSS software version 16.0 (SPSS Inc., Chicago, IL). All p values <0.05 were considered statisticallysignificant. Results: A total of 60 subjects were enrolled in the study. There was no significant difference in the mean concentration of plasma TTR among women with EPL 322.20(187.33-444.10) µg/ml and normal pregnant women 224.32(176.06-509.97) µg/ml (p=0.501). However, a significant difference was observed in the TACamong women with EPL 0.58 (0.51-0.70) mM/μl and normal pregnant women 0.71 (0.63-0.79) mM/μl (p=0.006). No significant correlation was seen between TTR and antioxidant capacity. Conclusion: Our study failed to demonstrate any relationship between plasma TTR levels and EPL. Antioxidant capacity was lower among EPL patients suggesting the importance of supplementation with antioxidants to prevent poor outcomes in pregnancy.

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“…In general, there are two types of miscarriages: fertilized ovum-dependent and mother-dependent. Mother immune-related causes of pregnancy complications account for about 5–10% of all lost pregnancies and doctors and scientists are more interested in uncovering the mechanisms involved in miscarriage 1 – 6 .…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of neutrophil extracellular traps (NETs) and nitric oxide-(NO)-dependent oxidative stress in women who miscarried

Omeljaniuk

Jabłońska

Garley

et al. 2020

Sci Rep

Self Cite

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Pregnancy loss is a multidisciplinary problem which concerns researchers from the fields of medicine, epidemiology, psychology, and public health. The primary objective of the present study was to explain the potential role of neutrophil extracellular traps (NETs) in the process of spontaneous miscarriage. Enzyme-linked immunosorbent assay to assess the levels of biomarkers of NETs in the serum of examined women was conducted. Furthermore, levels of nitric oxide (NO) and late markers of its action were measured in serum samples. Analyses results demonstrated the existence of NETs in the placental tissue of women who miscarried as well as a simultaneous increase in the levels of myeloperoxidase and pentraxin 3. This clearly confirms the participation of NETs in the course of pregnancy loss. Women who have had a miscarriage but did not show the presence of NETs in their placenta exhibited the highest contents of NO, nitrotyrosine, and malondialdehyde suggesting a different pathway leading to pregnancy loss associated with disturbed oxidative–antioxidative processes. Although study results demonstrate new aspects associated with the formation of NETs they are not, however, sufficient to unambiguously determine the role of NETs in the course of miscarriage.

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Antioxidant status in women who have had a miscarriage

Cited by 35 publications

References 36 publications

Reference Values of 14 Serum Trace Elements for Pregnant Chinese Women: A Cross-Sectional Study in the China Nutrition and Health Survey 2010–2012

Reference Values of 14 Serum Trace Elements for Pregnant Chinese Women: A Cross-Sectional Study in the China Nutrition and Health Survey 2010–2012

The Utility of Plasma Transthyretin and Antioxidants as aBiomarker of Early Pregnancy Loss - A Pilot Study

Biomarkers of neutrophil extracellular traps (NETs) and nitric oxide-(NO)-dependent oxidative stress in women who miscarried

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