Antioxidant study of biaryls synthesized in the presence of Aliquat-336 activated by ultrasound

Abstract

In this work we describe the study of some Suzuki coupling reactions of an aryl halide with arylboronic acids. The reaction yields obtained were increased through sonochemical activation and in the presence of a phase transfer catalyst for a very short period of time. The isolated products obtained are highly pure. In this context, we propose the reaction mechanisms for these reactions in the presence of a catalyst. The synthesized compounds were screened for their antioxidant activity using the 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing power (FRP) assay and ferrous ion chelating (FIC) methods. It was found that the synthesized biaryl compounds show an enhancing antioxidant activity.