Antioxidant supplementation for sickle cell disease

Bolarinwa, Abiola; Oduwole, Olabisi; Okebe, Joseph; Ogbenna, Ann Abiola; Otokiti, Oluwakemi; Olatinwo, A T

doi:10.1002/14651858.cd013590

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…antagonism of heavy metals in order to, nullifying their capacity to generate free radicals, thereby neutralizing their oxidative effect and interrupting the auto-oxidative chain reaction (Bolarinwa et al, 2020). Liver and kidney are important organs when the effects of toxins are investigated, since these organs play a central role in the metabolism and detoxi cation of biological substances.…”

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confidence: 99%

The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

El-Amawy

Zaahkouk

Rasheed

et al. 2021

Preprint

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The study was designed to clarify the hepato-renal protective effects of propolis extract against heavy metals-induced toxicity via oral administration to the males of albino rats. Lead (Pb), Nickel (Ni), Cadmium (Cd), and Antimony (Sb) are toxic heavy metals have the ability to produce reactive radicals in the biological systems causing public and animals health hazards through disrupting balances between pro-oxidant and antioxidant defense system, resulting in excessive reactive oxygen species (ROS) production. The most commonly affected organs are liver and kidney. Propolis is a natural product with different shapes and resinous substance collected by honey bees, it attenuates many diseases damage due to its anti-oxidative action and its potentiality to minimize the deleterious effects of free radicals on tissues. The concentrations of Pb, Cd, Ni and Sb as well as the activities of antioxidants endogenous enzymes including; glutathione peroxidase (Gpx), glutathione reductase (GR), catalase (CAT), and superoxide dismutase (SOD) were all determined in the tissues of liver and kidney; while aspartate transaminase (ASAT), alanine transaminase (ALAT), total protein (TP), urea and createnine, were measured in the serum of experimental rats beside histopathologicl examination in the tissues of liver and kidney. The oral administration of propolis provided a significantly therapeutic role against multi-metals-induced hepato-renal toxicity with relative improving to histopathological changes because of its scavenging and chelating properties as concluded from the present investigation.

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confidence: 99%

The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

El-Amawy

Zaahkouk

Rasheed

et al. 2021

Preprint

View full text Add to dashboard Cite

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Antioxidant supplementation for sickle cell disease

Bolarinwa,

Oduwole,

Okebe

et al. 2024

Cochrane Database of Systematic Reviews

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Background Sickle cell disease (SCD) refers to a group of genetic disorders characterized by the presence of an abnormal haemoglobin molecule called haemoglobin S (HbS). When subjected to oxidative stress from low oxygen concentrations, HbS molecules form rigid polymers, giving the red cell the typical sickle shape. Antioxidants have been shown to reduce oxidative stress and improve outcomes in other diseases associated with oxidative stress. Therefore, it is important to review and synthesize the available evidence on the effect of antioxidants on the clinical outcomes of people with SCD. Objectives To assess the effectiveness and safety of antioxidant supplementation for improving health outcomes in people with SCD. Search methods We used standard, extensive Cochrane search methods. The latest search date was 15 August 2023. Selection criteria We included randomized and quasi‐randomized controlled trials comparing antioxidant supplementation to placebo, other antioxidants, or different doses of antioxidants, in people with SCD. Data collection and analysis Two authors independently extracted data, assessed the risk of bias and certainty of the evidence, and reported according to Cochrane methodological procedures. Main results The review included 1609 participants in 26 studies, with 17 comparisons. We rated 13 studies as having a high risk of bias overall, and 13 studies as having an unclear risk of bias overall due to study limitations. We used GRADE to rate the certainty of evidence. Only eight studies reported on our important outcomes at six months. Vitamin C (1400 mg) plus vitamin E (800 mg) versus placebo Based on evidence from one study in 83 participants, vitamin C (1400 mg) plus vitamin E (800 mg) may not be better than placebo at reducing the frequency of crisis (risk ratio (RR) 1.18, 95% confidence interval (CI) 0.64 to 2.18), the severity of pain (RR 1.33, 95% CI 0.40 to 4.37), or adverse effects (AE), of which the most common were headache, nausea, fatigue, diarrhoea, and epigastric pain (RR 0.56, 95% CI 0.31 to 1.00). Vitamin C plus vitamin E may increase the risk of SCD‐related complications (acute chest syndrome: RR 2.66, 95% CI 0.77 to 9.13; 1 study, 83 participants), and increase haemoglobin level (median (interquartile range) 90 (81 to 96) g/L versus 93.5 (84 to 105) g/L) (1 study, 83 participants) compared to placebo. However, the evidence for all the above effects is very uncertain. The study did not report on quality of life (QoL) of participants and their caregivers, nor on frequency of hospitalization. Zinc versus placebo Zinc may not be better than placebo at reducing the frequency of crisis at six months (rate ratio 0.62, 95% CI 0.17 to 2.29; 1 study, 36 participants; low‐certainty evidence). We are uncertain whether zinc is better than placebo at ...

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Antioxidant supplementation for sickle cell disease

Cited by 2 publications

References 34 publications

The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

The protective role of propolis against multi heavy metals-induced oxidative stress-hepato-renal damage in the male of albino rats

Antioxidant supplementation for sickle cell disease

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