Antioxidant supplementation in pregnant women with low antioxidant status

Wibowo, Noroyono; Purwosunu, Yuditiya; Sekizawa, Akihiko; Farina, Antonio; Idriansyah, Liana; Fitriana, Ika

doi:10.1111/j.1447-0756.2012.01855.x

Cited by 32 publications

(17 citation statements)

References 34 publications

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“…Wibowo et al showed that supplementation of minerals with www. journals.viamedica.pl/ginekologia_polska antioxidant function, had a positive effect on the reduction of preeclampsia incidence during the initial stage of pregnancy in women not diagnosed with diabetes type 1 [31].…”

Section: Discussionmentioning

confidence: 99%

Selected trace elements concentrations in pregnancy and their possible role — literature review

et al. 2017

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The aim of this study was to review the role of selected trace elements in pregnancy and fetal development. Citations related to the role of iron (Fe), zinc (Zn), manganese (Mn), copper (Cu) and selenium (Se) during pregnancy were searched in PubMed, Medline, Web of Science, using keywords and MeSH terms. Inadequate supply of trace elements can cause abnormalities of fetal development and predispose a child to disorders later on in life. Trace elements are the key elements of complex enzymes responsible for the modulation of the antioxidant defense system of the organism. It has been suggested that there is a correlation between reduced levels of trace elements essential for antioxidant function in the body of pregnant women, and an increased risk of developing preeclampsia. Trace elements are components of numerous regulatory enzymes and hormones essential to the division and differentiation of fetal cells and their further development. Mineral deficiencies in pregnant women can cause birth defects of the central nervous system, and growth disorders. Future research should be directed to explain the interaction between trace elements, and establish the optimum levels of macro and micronutrients supplementation, as well as determine the reference values for trace elements in the maternal serum, umbilical cord blood and amniotic fluid.

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Section: Discussionmentioning

confidence: 99%

Selected trace elements concentrations in pregnancy and their possible role — literature review

et al. 2017

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“…In broad agreement with these findings, a randomised, placebo-controlled trial of 110 pregnant women (between 8-12 weeks gestation) who had low baseline antioxidant status were treated with either antioxidants or control diets daily until 2 weeks' postpartum. The study reported significant differences between the supplementation and control group for the incidence of pre-eclampsia (2.0% versus 14.5%) ,this study also found that mRNA levels of plasma SOD were significantly higher in the vitamin supplemented vs placebo supplemented women, providing evidence for a systemic antioxidant effect of these vitamins [41].…”

Section: Accepted Manuscriptmentioning

confidence: 67%

Placental antioxidant enzyme status and lipid peroxidation in pregnant women with type 1 diabetes: The effect of vitamin C and E supplementation

Johnston

McCance

Holmes

et al. 2016

Journal of Diabetes and its Complications

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“…If we can detect FGR occurrence earlier, the patient developing FGR could be cared in an advanced medical center before onset and might reduce the risk of FGR by antioxidant supplementation like the preeclampsia prophylaxis we reported. 28 Of note, there were more missing values for the mRNA method than the protein method. We were able to replace some of the missing data by using an imputation method because we had longitudinal data.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Fetal Growth Restriction by Analyzing the Messenger RNAs of Angiogenic Factor in the Plasma of Pregnant Women

et al. 2015

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Objective: To predict the occurrence of fetal growth restriction (FGR) by analyzing messenger RNA (mRNA) expression levels of vascular endothelial growth factor receptor 1 (fms-like tyrosine kinase 1 [Flt-1]) in maternal blood. Study Design: Eleven women with FGR were matched with 88 controls. Plasma samples were obtained during each trimester. The Flt-1 mRNA expression levels were compared between groups. Predicted probabilities were calculated, and sensitivity-specificity (receiver-operating characteristic [ROC]) curves were assessed based on regression models for each trimester measurement and possible combinations of measurements. Results: The mRNA levels of the FGR group during all trimesters were significantly higher than those of the control group. The ROC curve of combined first and second trimester data yielded a detection rate of 60% at a 10% false-positive rate, with an area under curve of 0.79. Conclusion: The Flt-1 mRNA expression in maternal blood can be used as a marker to predict the development of FGR, long before a clinical diagnosis is made.

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Antioxidant supplementation in pregnant women with low antioxidant status

Abstract: Supplementation of women with low antioxidant status with micronutrients containing antioxidants during early gestation might reduce the risk of pre-eclampsia.

Cited by 32 publications

References 34 publications

Selected trace elements concentrations in pregnancy and their possible role — literature review

Selected trace elements concentrations in pregnancy and their possible role — literature review

Placental antioxidant enzyme status and lipid peroxidation in pregnant women with type 1 diabetes: The effect of vitamin C and E supplementation

Prediction of Fetal Growth Restriction by Analyzing the Messenger RNAs of Angiogenic Factor in the Plasma of Pregnant Women

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