Antioxidant, α-amylase inhibitory and oxidative DNA damage protective property of Boerhaavia diffusa (Linn.) root

Akhter, Firoz; Hashim, Arshya; Khan, M. Salman; Ahmad, Saheem; Iqbal, Danish; Srivastava, Ashwini K.; Siddiqui, Mohammed Haris

doi:10.1016/j.sajb.2013.06.024

Cited by 47 publications

(35 citation statements)

References 31 publications

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“…In some investigations, attempts have been made to study the indigenous plants, which show the inhibitory effect of glucose utilization and are used as antidiabetic agents in the traditional system of medicine 9 . Boerhaavia diffusa, also known as Punarnava, is a representative of the family Nyctaginaceae and has been found to be of great medicinal value 10,11 . In continuation to our previous in vitro study which demonstrated the antioxidant, α-amylase inhibitory and oxidative DNA damage protective properties of Boerhaavia diffusa (Linn.)…”

Section: Introductionmentioning

confidence: 99%

Therapeutic efficacy of Boerhaavia diffusa (Linn.) root methanolic extract in attenuating streptozotocin-induced diabetes, diabetes-linked hyperlipidemia and oxidative-stress in rats

et al. 2019

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Introduction:We have previously demonstrated that sequentially extracted methanolic fractions of Boerhaavia diffusa (Linn.) showed marked antioxidant, antidiabetic and oxidative-DNA damage protective properties in vitro. The present study was undertaken to evaluate the beneficial effects of B.diffusa (Linn.) methanolic root extract and its partially purified bioactive fraction on streptozotocin (STZ)-induced hyperglycemia and hyperlipidemia in rats. Methods: The diabetic rats were treated for fourteen weeks either with methanolic extract of B. diffusa root (D-MT1, D-MT2, and D-MT3 : doses of 50, 150, and 300 mg/rat/day, respectively), partially isolated bioactive fraction (D-BT: 0.5 mg/rat/day), or glibenclamide (D-GT: 0.5 mg/rat/day). Results: The level of fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) were significantly alleviated in D-MT-and D-BTtreated groups after fourteen weeks of administration. Moreover, plasma lipid profile, free fatty acids (FFAs), phospholipids (PLs), HMG-CoA reductase (HMG-R) activity, conjugated diene (CD), lipid hydroperoxide (LOOH), and malondialdehyde (MDA) were also markedly ameliorate d in all treatment groups. In addition, the activity of antioxidant enzymes, e.g., superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (Gred), and glutathione-S-transferase (GST), were also significantly restored by D-MT -and D-BT -treated groups. Furthermore, histologically, all the unseemly features of nephropathy were extensively regressed and normalized by the administration of B. diffusa and its bioactive fraction. Conclusions: Our results demonstrate a strong antidiabetic and hypolipidemic impact of B. diffusa extract an ideal alternative therapeutic agent in the prevention and treatment of diabetes as well as diabetes-linked hyperlipidemia.Cite this article : Akhter F, Alvi S S, Ahmad P, Iqbal D, Alshehri B M, Khan M S. Therapeutic efficacy of Boerhaavia diffusa (Linn.) root methanolic extract in attenuating streptozotocin-induced diabetes, diabetes-linked hyperlipidemia and oxidative-stress in rats. Biomed. Res. Ther.; 6(7):3293-3306.

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Section: Introductionmentioning

confidence: 99%

Therapeutic efficacy of Boerhaavia diffusa (Linn.) root methanolic extract in attenuating streptozotocin-induced diabetes, diabetes-linked hyperlipidemia and oxidative-stress in rats

et al. 2019

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“…As shown in Table 3, the ethyl acetate fraction exhibited a higher inhibitory effect (IC 50 0.5±0 μg/ml) than did the other fractions, and the hexane fraction showed the lowest inhibitory effect (IC 50 >100 μg/ml). Additionally, starch degradation by pancreatic α-amylase was inhibited by 200 μg of the ethyl acetate and n-butanol fractions ( Table 3), indicating that the significant inhibition of α-glucosidase and α-amylase activities by the ethyl acetate fraction (versus the other fractions) is due to the presence of polyphenolic compounds, which are known to be soluble in polar solvents [29] .…”

Section: Resultsmentioning

confidence: 99%

Antioxidant, Antimicrobial, and Antidiabetic Activities of Crowberry Fruits

Hyun¹,

H.²,

Han³

et al. 2018

pharmaceutical-sciences

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Hyun et al.: Biological Activity of Crowberry FruitsAlthough crowberry is a relatively under-utilized wild berry, it holds considerable potential for application in the food and cosmetic industries due to its high phenolic content. In this study, antioxidant, antimicrobial, and antidiabetic activities of crowberry were investigated to shed light on its potential health benefits. Antioxidant activity was evaluated using the 1,1-dephenyl-2-picryl-hydrazyl free radical scavenging, reducing power, and total antioxidant capacity. The crude 70 % ethanol extract, ethyl acetate and butanol fraction of the fruit showed strong antioxidant activity. In addition, the ethyl acetate fraction showed antimicrobial activity against Gram-negative bacteria and significant inhibition of α-glucosidase and α-amylase activities. These findings suggested that the ethyl acetate fraction of the crude 70 % ethanol extract could serve as a useful source of dietary supplements. Furthermore, the analysis of correlation between the phytochemical content and biological activity of crowberry suggested that phenolic compounds could be the major contributors to the antioxidant and antidiabetic activities of the fruit extract. Taken together, these results suggested that crowberry fruits could serve as potential antioxidant and antidiabetic supplements.

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“…Boerhaavia diffusa is a known traditional medicinal plant for improving health benefits because of its antioxidant property. [21] Capsaicin from capsicum spp. has been reported for potent inhibition of the growth of ERpositive (MCF-7, T47D, BT-474) and ER-negative (SKBR-3, MDA-MB231) breast cancer cell lines.…”

Section: Discussionmentioning

confidence: 99%