Antioxidants and lipid peroxidation status in the blood of patients with psoriasis

Kökçam, İbrahim; Nazıroğlu, Mustafa

doi:10.1016/s0009-8981(99)00150-3

Cited by 86 publications

(44 citation statements)

References 22 publications

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“…uncontrolled ROS production plays a crucial role in enhancing the disease complexity in psoriasis. 12 Endothelial cells and vascular smooth cells produce ROS which oxidize low density lipoprotein and thereby initiate atherosclerosis. In addition, involvement of ROS in cell membrane damage via lipid peroxidation and its resultant products such as lipid radicals (L•), lipid peroxides (LOO•), lipid hydroperoxides and highly reactive aldehydes which play a crucial role in the development and progression of vascular complications in psoriasis.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, as best of our knowledge, previous studies on psoriasis patients have not included systemic inflammation, oxidative stress and dyslipidemia in a single setting. [11][12][13] Therefore, the present work aims to evaluate the levels of c-reactive protein (CRP), MDA, lipid profile and Apo B/A1 ratio in active psoriasis patients and to determine their role in prediction of CVD risk in same population.…”

Section: Introductionmentioning

confidence: 99%

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Systemic inflammation, oxidative stress and apolipoprotein B/A1 ratio in active psoriasis: bridging an apparent paradox

et al. 2015

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Background: Psoriasis is characterized by systemic increase of inflammation and oxidative stress. In addition, increased incidence of dyslipidemia in dermatological disorders is also in alarming phase. It is conceivable that association of inflammation, oxidative stress and dyslipidemia enhances the future the risk of cardiovascular disease (CVD) in psoriasis patients. The main of the study is to estimate the marker of systemic inflammation, oxidative stress, plasma lipid profile and apolipoprotein levels in psoriasis patients and to determine their role in predicting CVD risk in psoriasis.Methods: The study population consist of subjects categorized into two groups; Group I: Healthy controls and Group II: Psoriasis patients (n= 25 in each group). Erythrocyte malondialdehyde (MDA), plasma C-reactive protein (CRP) and lipid profile along with apolipoprotein B and A1 were measured and statistically analyzed using standard methods.Results: Plasma CRP, total cholesterol, triglycerides, LDL-cholesterol and MDA levels were significantly high (p<0.05) in patient group as compared to healthy controls. HDL-cholesterol levels were altered insignificantly (p<0.1) in patient group. Plasma Apo B/Apo A1 ratio were increased significantly (p<0.01) in patient groups as compared to controls.Conclusions: Thus, enhanced inflammation, oxidative stress along with increase in Apo B, A1 and its ratio authenticates the fact that these markers are more efficient in prediction of CVD risk in psoriasis patients than conventional lipid profile parameters.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systemic inflammation, oxidative stress and apolipoprotein B/A1 ratio in active psoriasis: bridging an apparent paradox

et al. 2015

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“…The lipid peroxidation content in plasma, RBC, liver and skin samples was measured as MDA, which is the end product of lipid peroxidation by the method of Placer et al [11] as described in previous studies [6,12]. The values of MDA were expressed as nanomoles per milliliter plasma and hemolyzed RBC and nanomoles per gram tissue.…”

Section: Laboratory Methodsmentioning

confidence: 99%

Beneficial Effects of Intraperitoneally Administered Alpha-Tocopheryl Acetate on the Levels of Lipid Peroxide and Activity of Glutathione Peroxidase and Superoxide Dismutase in Skin, Blood and Liver of Thermally Injured Guinea Pigs

Nazıroğlu

Kökçam²,

Yılmaz³

2003

Skin Pharmacol Physiol

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The aim of this study was to investigate the effects of intraperitoneal α-tocopheryl acetate administration on concentration of lipid peroxide (as malonyldialdehyde, MDA), reduced glutathione (GSH), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in plasma, red blood cells (RBC), skin and liver of thermally injured guinea pigs. MDA levels in the plasma, skin and liver were increased at the 15th min after the thermal injury compared to the control group. However, they were significantly lower in the α-tocopheryl-acetate-treated groups than both control and thermally injured groups from the 15th min to the 6th day. SOD activity of the skin and RBC and vitamin E levels in the plasma were significantly decreased between the 15th min and 6th day and then both parameters, i.e. SOD and vitamin E, were significantly increased by α-tocopheryl acetate administration. GSH-Px activity in the skin was also significantly decreased in groups from the 15th min to the 6th day, whereas it remained unchanged by the α-tocopheryl acetate administration. On the other hand, GSH-Px activity and GSH levels in the RBC remained the same during both thermal injury and α-tocopheryl acetate administration. In conclusion, we observed that the intraperitoneal administration of α-tocopheryl acetate protects the skin against thermal injury, which suggests that it may be due to the upregulation of enzymatic antioxidants.

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“…It has been reported that plasma GSH concentrations remain at mM levels in healthy humans. 32,33) It has been also demonstrated that arsenic concentrations in the plasma of chronic arsenic poisoning patients is at the mM level. 34) Therefore, large amounts of cytotoxic MMAs III DG and DMAs III G are probably not produced nonenzymatically at in vivo levels of arsenicals and GSH.…”

Section: Mmasmentioning

confidence: 99%

Cytolethality of Glutathione Conjugates with Monomethylarsenic or Dimethylarsenic Compounds

Kojima

Sakurai

Waalkes

et al. 2005

Biological & Pharmaceutical Bulletin

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Arsenic is a metalloid element that is widely distributed in the environment as a natural component of soil and in water as inorganic trivalent (arsenite) or pentavalent (arsenate) forms, 1) and its toxicity has been known since ancient times. In Asia and the Americas, chronic arsenic poisoning has occurred as a result of the consumption of high levels of arsenic-contaminated well water. Epidemiological studies have provided clear evidence that inorganic arsenicals are a human carcinogen with target sites including liver, skin, lung, kidney and urinary bladder.2) However, the mechanism of arsenic-induced impediment is not clear. On the other hand, inorganic arsenite has emerged as a potent chemotherapeutic agent with remarkable efficacy for certain human cancers, such as acute promyelocytic leukemia.3,4) It would thus appear that environmental and iatrogenic exposure to arsenic will continue to be common.In humans and numerous experimental animals, pentavalent arsenate is rapidly reduced to trivalent arsenite. 5) Subsequently, it is enzymatically methylated into organic arsenicals, such as monomethylarsonic acid (MMAs V ) and dimethylarsinic acid (DMAs V ).6) MMAs V and DMAs V are the major organic pentavalent arsenic metabolites in human urine after exposure to inorganic arsenicals. 5,6) It is believed that methylation of inorganic arsenicals results in a reduction in general toxicity, as indicated by their increased in vivo lethal dose in 50% of a population (LD 50 ) and in vitro lethal concentration in 50% of a population (LC 50 ). 7,8) However, recent studies have increasingly suggested that the methylation of inorganic arsenicals is not a universal detoxification mechanism. Some researchers have reported that trivalent methyl arsenicals, such as monomethylarsonous acid (MMAs III ) and dimethylarsinous acid (DMAs III ), were found in urine collected from people who had been exposed to high concentrations of inorganic arsenicals, 9,10) and that synthetic trivalent methyl arsenicals, such as monomethylarsine oxide (MMAs III O) and iododimethylarsine (DMAs III I), are more cytotoxic in vitro than inorganic arsenicals and pentavalent methyl arsenicals.11) Trivalent methyl arsenicals are thought to be generated as arsenical-glutathione conjugates, such as mono-methylarsonous diglutathione (MMAs III DG) and dimethylarsinous glutathione (DMAs III G), in the human body. [12][13][14] It was also reported that reduced glutathione (GSH) nonenzymatically reduces pentavalent methyl arsenicals to trivalent methyl arsenicals in water, thus resulting in the formation of MMAs III DG and DMAs III G in vitro.

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Antioxidants and lipid peroxidation status in the blood of patients with psoriasis

Cited by 86 publications

References 22 publications

Systemic inflammation, oxidative stress and apolipoprotein B/A1 ratio in active psoriasis: bridging an apparent paradox

Systemic inflammation, oxidative stress and apolipoprotein B/A1 ratio in active psoriasis: bridging an apparent paradox

Beneficial Effects of Intraperitoneally Administered Alpha-Tocopheryl Acetate on the Levels of Lipid Peroxide and Activity of Glutathione Peroxidase and Superoxide Dismutase in Skin, Blood and Liver of Thermally Injured Guinea Pigs

Cytolethality of Glutathione Conjugates with Monomethylarsenic or Dimethylarsenic Compounds

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