Antioxidants for chronic kidney disease

Jun, Min; Venkataraman, Vinod; Razavian, Mona; Cooper, Bruce A.; Zoungas, Sophia; Ninomiya, Toshiharu; Webster, Angela C; Perkovic, Vlado

doi:10.1002/14651858.cd008176.pub2

Cited by 97 publications

(85 citation statements)

References 67 publications

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“…In support of this, experimental evidence for ROS activation of the HBP in the Increased levels of several plasmatic oxidative markers have been demonstrated in CKD (21,55,56), and CKD patients have defects in the antioxidant defense system (57). Moreover, several clinical studies suggest that antioxidant therapy in CKD patients may prevent the progression to end-stage renal disease and reduce CV mortality (20,58). Oxidative stress also contributes to insulin resistance in CKD (15).…”

Section: Discussionmentioning

confidence: 99%

Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease

Koppe¹,

Nyam²,

Vivot³

et al. 2016

Journal of Clinical Investigation

122

105

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of the Rodent Metabolic Phenotyping core facility of the CRCHUM for metabolic studies in mice; M. Guévremont, J. Morin, and the Cellular Physiology Service core of the CRCHUM for quantification of β cell mass and αLISA assay; C. Tremblay (CRCHUM) for valuable technical assistance; E. Joly for technical advice; and M. Ferdaoussi for fruitful discussions.Address correspondence to: Vincent Poitout, CRCHUM, 900 Saint-Denis Street, Montreal, Quebec, H2X 0A9, Canada. Phone: 514.890.8044; E-mail: vincent.poitout@umontreal.ca.the CHUM (protocols ND-05-035 and 16-048, respectively). Written consent for research was obtained from all donors.

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Section: Discussionmentioning

confidence: 99%

Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease

Koppe¹,

Nyam²,

Vivot³

et al. 2016

Journal of Clinical Investigation

122

105

View full text Add to dashboard Cite

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“…Despite evidence for harmful effects in the general population of high doses of some common supplements (β-carotene, vitamin E, vitamin A) [50,51], there is evidence, although limited, that chronically haemodialysed patients could benefit from the use of antioxidants to prevent cardiovascular complications [52,53]. However, there are also some contradictory findings which suggest that the mechanism and consequences of oxidative damage in ESRD need closer examination before antioxidant interventions are evaluated [54].…”

Section: Discussionmentioning

confidence: 99%

Ankyrin is the major oxidised protein in erythrocyte membranes from end-stage renal disease patients on chronic haemodialysis and oxidation is decreased by dialysis and vitamin C supplementation

Ruskovska

Bennett

Brown

et al. 2014

Free Radical Research

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Chronically haemodialysed end-stage renal disease patients are at high risk of morbidity arising from complications of dialysis, the underlying pathology that has led to renal disease and the complex pathology of chronic kidney disease. Anaemia is commonplace and its origins are multifactorial, involving reduced renal erythropoietin production, accumulation of uremic toxins and an increase in erythrocyte fragility.Oxidative damage is a common risk factor in renal disease and its co-morbidities, and is known to cause erythrocyte fragility. Therefore we have investigated the hypothesis that specific erythrocyte membrane proteins are more oxidised in endstage renal disease patients and that vitamin C supplementation can ameliorate membrane protein oxidation.Eleven patients and fifteen control subjects were recruited to the study. Patients were supplemented with 2 x 500mg vitamin C per day for four weeks. Erythrocyte membrane proteins were prepared pre-and post-vitamin C supplementation for determination of protein oxidation. Total protein carbonyls were reduced by vitamin C supplementation but not by dialysis when investigated by enzyme linked immunosorbent assay. Using a western blot to detect oxidised proteins, one protein band, later identified as containing ankyrin, was found to be oxidised in patients but not controls and was reduced significantly by 60% in all patients after dialysis and by 20% after vitamin C treatment pre-dialysis. Ankyrin oxidation analysis may be useful in a stratified medicines approach as a possible marker to identify requirements for intervention in dialysis patients.

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“…Various studies have reported that in patients with renal failure, an altered redox balance results from greater levels of ROS, RNS and some toxins together with an impaired antioxidant capacity. [10][11][12][13][14] An increase in reactive species is known to be involved in inflammatory glomerular injury by stimulating the overproduction of several mediators, including cytokines and chemokines. One of the most important of these mediators is nuclear factor kappa beta (NF-kb).…”

Section: Introductionmentioning

confidence: 99%

A review of the impact of oxidative stress and some antioxidant therapies on renal damage

et al. 2015

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An increase in the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) leads to complications during chronic kidney disease (CKD). This increase essentially derives from the impairment of natural antioxidant systems of the organism. The resulting oxidative stress produces damage to kidney tissue, especially by affecting nephrons and more generally by disrupting the function and structure of the glomerulus and interstitial tubule. This leads to a rapid decline in the condition of the patient and finally renal failure. Possible causes of kidney tissue damage are explored, as are different therapies, especially those related to the administration of antioxidants.ARTICLE HISTORY

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Antioxidants for chronic kidney disease

Cited by 97 publications

References 67 publications

Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease

Urea impairs β cell glycolysis and insulin secretion in chronic kidney disease

Ankyrin is the major oxidised protein in erythrocyte membranes from end-stage renal disease patients on chronic haemodialysis and oxidation is decreased by dialysis and vitamin C supplementation

A review of the impact of oxidative stress and some antioxidant therapies on renal damage

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