Antioxidants from Galium verum as Ingredients for the Design of New Dermatocosmetic Products

Abstract

The aim of this study was to use plant extracts from spontaneous flora of Moldova (Rediu-Iasi area, Romania) as polyphenols and flavonoids source in order to obtain new dermato-cosmetic formulas to prevent the actions of oxidative stress on skin. Plant extracts (from raw and dried Galium verum sp.) were obtained by: cold classical maceration (M), heat reflux extraction (HTE) and ultrasound assisted extraction (UAE). The extracts were characterized by spectrophotometric method (for polyphenols and flavonoids content and for DPPH antioxidant activity evaluation). In order to evaluate the combating and/or attenuating effects of oxidative stress on skin, the study was continued with the elaboration of emulsions that incorporate one of these extracts. The emulsions were preliminarily characterized by determining the stability over time. The obtained results encourage research in the direction of deeper characterization of these emulsions to determine the microbiological stability and dermatological tests performed on the skin treated with these new products.

Phytochemical Screening and Antioxidant Activity of Selected Estonian Galium Species

“…Analytical investigation allows for the determination of the phytochemical composition and confirmation of specific therapeutic properties of the plants already acknowledged for their potential by ethnomedicine [ 1 , 2 , 3 , 4 , 5 ]. The Galium L. genus, comprising about 667 species found worldwide, over a third of which can be found in Europe, includes several species that have been used in traditional medicine to alleviate a variety of ailments [ 6 , 7 ]. Galium verum has been used as a sedative, diuretic, and choleretic, as well as to treat gout, epilepsy, and spasms; Galium aparine has been used to reduce infection and inflammation, to treat wounds, burns, and skin diseases; Galium mollugo has been used as vulnerary, and to treat hysteria and epilepsy [ 7 , 8 , 9 ].…”

“…The Galium L. genus, comprising about 667 species found worldwide, over a third of which can be found in Europe, includes several species that have been used in traditional medicine to alleviate a variety of ailments [ 6 , 7 ]. Galium verum has been used as a sedative, diuretic, and choleretic, as well as to treat gout, epilepsy, and spasms; Galium aparine has been used to reduce infection and inflammation, to treat wounds, burns, and skin diseases; Galium mollugo has been used as vulnerary, and to treat hysteria and epilepsy [ 7 , 8 , 9 ]. Many scientific studies have confirmed that the representatives of the Galium genus exhibit a wide range of biological activities, including antioxidant, anticancer, detoxicant, hepatoprotective, antihaemolytic, antibacterial, and antifungal effects [ 2 , 7 , 9 , 10 , 11 ].…”

“…Galium verum has been used as a sedative, diuretic, and choleretic, as well as to treat gout, epilepsy, and spasms; Galium aparine has been used to reduce infection and inflammation, to treat wounds, burns, and skin diseases; Galium mollugo has been used as vulnerary, and to treat hysteria and epilepsy [ 7 , 8 , 9 ]. Many scientific studies have confirmed that the representatives of the Galium genus exhibit a wide range of biological activities, including antioxidant, anticancer, detoxicant, hepatoprotective, antihaemolytic, antibacterial, and antifungal effects [ 2 , 7 , 9 , 10 , 11 ]. Phytochemicals are typically extracted from plant materials using alcohols or acetone in varying proportions of water, depending on the properties of the compounds of interest [ 9 ].…”

Preliminary Approaches to Cosmeceuticals Emulsions Based on N-ProlylPalmitoyl Tripeptide-56 Acetat-Bakuchiol Complex Intended to Combat Skin Oxidative Stress

“…The stability of the prepared emulsions was assessed throughout time as well as potential microbial contamination during storage or usage of dermato-cosmetic preparation [ 37 , 39 , 40 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ].…”

“…Centrifugation test . The physical stability of O/W emulsions was examined by the Centrifugation test to demonstrate their resistance to external factors such as centrifugal force [ 43 ]. After extensive centrifugation, there was no evidence of phase separation in any of the samples ( Table 1 )…”