Antioxidants in Complex Treatment of Pyoinflammatory Diseases in Maxillofacial Area

Subject. A review of the literature on the topical problem of dentistry — the etiology and pathogenesis of acute odontogenic purulent-inflammatory diseases is presented. The purpose of the research is to study the materials of publications. dedicated to the etiopathogenetic aspects of acute odontogenic infection. Methodology. The etiology and pathogenesis of acute odontogenic purulent-inflammatory diseases are described in detail, in the light of modern concepts. Results. The unfavorable factors influencing the increase in the frequency of acute odontogenic purulent-inflammatory diseases and the worsening of the clinical course are presented. It is noted that these diseases are explained by the effect of microbial associations, one of the frequent representatives of which are anaerobic bacteria, which significantly worsen the clinical picture of the disease. All theories of the pathogenesis of jaw osteomyelitis (vascular, allergic and neuro-trophic) are considered. At the same time, it was noted that the vascular, allergic and neuro-reflex components in the emergence and development of osteomyelitis of the jaws are realized against the background of a decrease in the level of general immunological and specific reactivity of the whole organism, as well as the failure of local immunity. Particular importance is attached to disorders of the systems of neuroregulation and microcirculation. It is noted that sensitization and neuroreflex effects on the inflammation focus are factors contributing to the transition of the reversible phase of inflammation (osteitis) to the irreversible one (osteomyelitis), and microcirculation disorders in the inflammation focus are characterized as the main stage in the chain of pathophysiological processes leading to irreversible changes. Attention is drawn to the fact that in recent years, great importance in maintaining homeostasis in acute odontogenic pyoinflammatory diseases has been given to the antioxidant system, which is directly involved in the regulation of the molecular mechanisms of nonspecific resistance of the organism to the damaging action of various pathogenic factors. Findings. The results of the review indicate that knowledge of the peculiarities of the etiology and pathogenesis of acute odontogenic pyoinflammatory diseases is necessary for correct diagnosis, timely and adequate treatment, prognosis and prevention of complications. However, it should be recognized that this problem continues to remain relevant to this day due to the complexity of its study.

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Ethiopathogenetic Aspects Acute Odontogenic Infection

Ksembaev

Nesterova

Torgashova

et al. 2021

Actual Problems in Dentistry

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Effects of cytoflavin on biochemical indicators in patients with maxillofacial area phlegmons

Гайворонская¹,

Shvets²,

Шафранова³

2020

Kuban. nauсh. med. vestnik

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Aim. To assess the effect of cytoflavin on the dynamics of the blood and oral fluid prooxidant-antioxidant system in patients with maxillofacial area phlegmons.Materials and methods. 55 patients were included in the study. The patients were divided into three groups: control group (group 1, n = 20); comparison group (group 2, n = 15); patients with phlegmons of the maxillofacial area (group 3, n = 20). As part of therapy, the patients in group 3 were additionally receiving cytoflavin (10 ml cytoflavin in 200 ml saline solution, 1 time per day, for 6 days). The treatment and monitoring was performed over the period of 6 days, during which the blood and oral fluid indicators were estimated 4 times (day 1, 2, 4 and 6).Results. Cytoflavin had a positive effect on the state of the prooxidant-antioxidant balance in patients with maxillofacial area phlegmons. In comparison with the control group, patients in group 3 demonstrated a lower content of oxidative modifi cation products and a higher antioxidant activity of blood plasma. Cytoflavin therapy also led to an increase in the activity of glutathione peroxidase and reductase, as well as an increase in the concentration of glutathione at the last stage of the therapy.Conclusion. The obtained data indicate the potential of cytoflavin as part of complex metabolic therapy for patients with purulent inflammatory processes of the maxillofacial area.

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Antioxidants in Complex Treatment of Pyoinflammatory Diseases in Maxillofacial Area

Cited by 2 publications

References 4 publications

Ethiopathogenetic Aspects Acute Odontogenic Infection

Ethiopathogenetic Aspects Acute Odontogenic Infection

Effects of cytoflavin on biochemical indicators in patients with maxillofacial area phlegmons

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