Antioxidants of therapeutic relevance in COPD from the neotropical blueberry Anthopterus wardii

Abstract

Four flavone C-glycosides, isoorientin (1), orientin (2), vitexin (3), and isovitexin (4), were isolated from the neotropical blueberry of Anthopterus wardii, a so-called “superfruit”, using antioxidant activity-guided fractionation. A dose-response relationship of compounds 1–4 was determined for their anti-inflammatory activity against interleukin-8 (IL-8) and for the inhibition of matrix metalloproteinase-1 (MMP-1) expression, an inflammatory marker for chronic obstructive pulmonary disease. The four flavone C-glycosides exhibited inhibitory activity against IL-8 production and MMP-1 expression, with compounds 1, 3, and 4 having the most potent inhibitory activities in both assays at 100 μg/ml. The structures of compounds 1–4 were determined by spectroscopic methods. These flavone C-glycosides are reported for the first time in the Anthopterus genus.

Edible Myrciaria vexator fruits: Bioactive phenolics for potential COPD therapy

“…In comparison to reported MMP-1 inhibitory activities of antioxidant phenolics such as vitexin and isoorientin in the same COPD model, ellagic reduced MMP-1 expression at a far lower concentration. 19 The two flavone C-glyco-sides have already been identified as potential drug candidates for COPD. 19 …”

“…19 The two flavone C-glyco-sides have already been identified as potential drug candidates for COPD. 19 …”

Comparative suppression of NLRP3 inflammasome activation with LPS-induced inflammation by blueberry extracts (Vaccinium spp.)

“…33 This is associated with inhibition of TNF-a-induced inammatory responses, 34 and potential stimulation of anti-inammatory activity against interleukin-8 (IL-8) for inhibited of matrix metalloproteinase-1 (MMP-1) expression. 35 The anthocyanins of blueberries have been shown to reduce the activation of NF-kB, induced by IL-1b in intestinal epithelial Caco-2 cells. 36 These results support that blueberry bioactive compounds have potential bioactivities to act as dietary anti-inammatory agents.…”

Geleia de buriti (Mauritia flexuosa): agregação de valor aos frutos do cerrado brasileiro

“…Estudos têm demonstrado efeitos benéficos do consumo de frutas, os quais têm sido atribuídos à presença de nutrientes, como as vitaminas A, C e E (DE OLIVEIRA E SILVA et al, 2012;GAO et al, 2012;WANG et al, 2012), e principalmente ao conteúdo de compostos bioativos encontrados nos vegetais (FLORES et al, 2012;LI et al, 2013). Muitos desses compostos atuam como sequestradores de radicais livres, enquanto outros agem como quelantes de metais catalisadores de reações de geração de espécies reativas de oxigênio (HALLIWELL;GUTTERIDGE, 2007;FLOEGEL et al, 2011).…”