Antioxidants Supplementation During Exercise: Friends or Enemies for Cardiovascular Homeostasis?

Wang, Hongyun; Yang, Zijiang; Zhang, Xiao; Xie, Jinxin; Xie, Yuling; Gokulnath, Priyanka; Vulugundam, Gururaja; Xiao, Junjie

doi:10.1007/s12265-022-10297-y

Cited by 7 publications

(2 citation statements)

References 111 publications

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“…Appropriate supplementation of antioxidants helped to improve antioxidant capacity and remove free radicals. [ 165 ] Some non‐enzyme antioxidant substances or drugs, such as vitamin C, vitamin E, glutathione, melatonin, etc., could capture active oxygen to prevent oxidative stress, thus reducing damage to tissues or cells. Administration of exogenous antioxidants or drugs during exercise protected the heart from oxidative stress damage.…”

Section: Cardiovascular Protection By Combining Exercise and Exogenou...mentioning

confidence: 99%

Moderate‐Intensity Exercise Maintains Redox Homeostasis for Cardiovascular Health

Jiang

Zhang

et al. 2023

Advanced Biology

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It is well known that exercise is beneficial for cardiovascular health. Oxidative stress is the common pathological basis of many cardiovascular diseases. The overproduction of free radicals, both reactive oxygen species and reactive nitrogen species, can lead to redox imbalance and exacerbate oxidative damage to the cardiovascular system. Maintaining redox homeostasis and enhancing anti‐oxidative capacity are critical mechanisms by which exercise protects against cardiovascular diseases. Moderate‐intensity exercise is an effective means to maintain cardiovascular redox homeostasis. Moderate‐intensity exercise reduces the risk of cardiovascular disease by improving mitochondrial function and anti‐oxidative capacity. It also attenuates adverse cardiac remodeling and enhances cardiac function. This paper reviews the primary mechanisms of moderate‐intensity exercise‐mediated redox homeostasis in the cardiovascular system. Exploring the role of exercise‐mediated redox homeostasis in the cardiovascular system is of great significance to the prevention and treatment of cardiovascular diseases.

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Section: Cardiovascular Protection By Combining Exercise and Exogenou...mentioning

confidence: 99%

Moderate‐Intensity Exercise Maintains Redox Homeostasis for Cardiovascular Health

Jiang

Zhang

et al. 2023

Advanced Biology

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“…For instance, it has been shown that ALA and DHLA have several positive health benefits, including as biological antioxidants, metal chelators and detoxification agents, being also able to reduce the oxidized forms of other antioxidant agents, including glutathione, vitamins C and E, and to modulate various signaling pathways, such as insulin and nuclear factor kappa B [12]. It has also been used forage-associated cardiovascular, cognitive, and neuromuscular deficits [13,14], to reform endothelial dysfunction [15], to decrease oxidative stress [16] and to inhibit the formation of atherosclerosis plaque [17].…”

Section: Introductionmentioning

confidence: 99%

Effect of alpha-lipoic acid on rat kidney and liver microsomes subjected to oxidative stress induced by ascorbate-Fe++

Edith¹,

Beatriz²,

Alejandro³

2022

GSC Biol. Pharm. Sci.

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Metabolic changes during kidney and liver disease can induce increased production of oxygen radicals that play an important role in the progression of kidney and liver damage and in the appearance of important comorbidities. In the study reported here, the effect of alpha-lipoic acid (ALA) on the chemiluminescence (CL) and TBARS determination of microsomes isolated from rat kidney and liver was analyzed. Oxidative stress in microsomes was induced by subjecting samples (1 mg of protein) to an ascorbate-Fe++-dependent (0.4 mM)-Fe++ (2.15 μM) prooxidant system at 37 °C for 120 min. Oxidative damage was quantified by two methods, TBARS and CL: CL was determined using a Packard 1900 TR liquid scintillation counter (Meriden CT, USA). CL was expressed as cpm (counts per minute) was read every 10 minutes to establish the course of peroxidation as a function of time. Likewise, the total value of cpm (sum of the readings) was used to compare the inhibitory effect of ALA using different concentrations corresponding to 0.05; 0.15 and 0.25 μg of ALA per mg of microsomal protein. Controls were run simultaneously without the addition of ascorbate-Fe++. It was observed that the CL was lower in the kidney and liver microsomes obtained from the ALA group than in the control group (without ALA). In addition, -ALA was found to be concentration-dependent (0.05, 0.15 and 0.25 μg of ALA per mg of solution) reduced in CL, measured as total cpm. After that it was done the determination of lipid peroxidation products (Thiobarbituric Acid Reactive Substances—TBARS). TBARS were measured in the microsomal samples. Lipoperoxidation inhibition depended on the concentration of ALA in the incubation mixture. The results show that for all the concentrations tested, a protective effect on the induced oxidative damage was found. CL and TBARS level analyzes indicate that ALA may act as an antioxidant protecting rat kidney and liver microsomes from lipoperoxidative damage.

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Cordyceps militaris acidic polysaccharides improve learning and memory impairment in mice with exercise fatigue through the PI3K/NRF2/HO-1 signalling pathway

Bai

Tan

Ren

et al. 2023

International Journal of Biological Macromolecules

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Antioxidants Supplementation During Exercise: Friends or Enemies for Cardiovascular Homeostasis?

Cited by 7 publications

References 111 publications

Moderate‐Intensity Exercise Maintains Redox Homeostasis for Cardiovascular Health

Moderate‐Intensity Exercise Maintains Redox Homeostasis for Cardiovascular Health

Effect of alpha-lipoic acid on rat kidney and liver microsomes subjected to oxidative stress induced by ascorbate-Fe++

Cordyceps militaris acidic polysaccharides improve learning and memory impairment in mice with exercise fatigue through the PI3K/NRF2/HO-1 signalling pathway

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