Antioxidants: their health benefits and plant sources.

Singh, None Rohit; Sharma, Sapna; Singh, Pankaj Kumar; Prakash, Devanand; Sharma, G. S.

doi:10.1079/9781780643632.0248

Cited by 22 publications

(9 citation statements)

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“…Through chromatographic separation, the methanolic extract of S. dulcificum leaves revealed presence of eight compounds including a mixture of b-sitosterol and stigmasterol, pheophytin-a, pheophytin-b, lupeol, lupenone, lupeol acetate, and a-tocopheryl quinone among which major ones are beneficial for health. For instance ''lupeol'' is reported to exhibit antiprotozoal, anti-inflammatory, anticarcinogenic, cardioprotective, antimicrobial, and hepatoprotective activities (Singh et al 2014). Similarly, the methanolic extract of the stem was reported to contain six pure compounds namely: propane-1,2,3-triol; 2,5-dimethoxyphenol; 3,4,5-trimethoxybenzoic acid; nicotinic acid; b-sitosterol, and stigmasterol (Cheng et al 2012).…”

Section: Phytochemical Properties and Medicinal Usesmentioning

confidence: 99%

Current knowledge and breeding perspectives for the miracle plant Synsepalum dulcificum (Schum. et Thonn.) Daniell

Achigan‐Dako

Tchokponhoué

N’Danikou

et al. 2015

Genet Resour Crop Evol

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Synsepalum dulcificum, an African native shrub, is a valuable species. All plant parts are of medicinal importance whereas the fruit known as magic berry, miracle berry, or sweet berry is consumed fresh. Surprisingly, very little is known on the species in terms of genotypes utilization and breeding. In this review we recalled the uses and importance of the species and suggested research avenues for an accelerated growth and fruit production. Synsepalum dulcificum is rich in glycoprotein and is an excellent natural sweetener and also a good candidate for the synthesis of drugs against diabetes. Furthermore, S. dulcificum has high content in phytochemical substances (e.g. (?)-epi-syringaresinol, vanillic acid, cyanidin-3-monogalactoside, and quercetin-3-monogalactoside) with various health and food benefits. Data on the nutrient content are limited. Likewise, knowledge on the reproductive biology and mating system is still narrow, combined with poorly developed horticultural practices. To fully exploit the potential of S. dulcificum prospective actions include:(1) improving the propagation and growth abilities of the species, (2) improving knowledge of floral biology and genetic diversity, (3) understanding the phenological phases of the species, gene expressions and how this contributes to metabolites accumulation and (4) improving genotypes for beverages, cosmetics and pharmaceutical industries and other value chains.

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Section: Phytochemical Properties and Medicinal Usesmentioning

confidence: 99%

Current knowledge and breeding perspectives for the miracle plant Synsepalum dulcificum (Schum. et Thonn.) Daniell

Achigan‐Dako

Tchokponhoué

N’Danikou

et al. 2015

Genet Resour Crop Evol

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“…Most antioxidants are natural plant compounds that can slow or stop the occurrence of degenerative reactions in the body [ 1 , 3 , 4 , 5 ], and they may be a promising source for the prevention or treatment of free radical-generated diseases such as atherosclerosis, hypertension, diabetes, cancer, Parkinson’s, Alzheimer’s, etc. [ 6 ]. By participating in DNA damage protection, they can prevent or modulate the process of carcinogenesis [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and DNA-Protective Potentials, Main Phenolic Compounds, and Microscopic Features of Koelreuteria paniculata Aerial Parts

et al. 2022

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Interest in plant extracts as a natural source of antioxidants has grown significantly in recent years. The tree species Koelreuteria paniculata deserves attention due to its wide distribution, good adaptability, and growth to the degree of invasiveness in a number of European countries. The purpose of the present study was to analyze flavonoids and phenolic acids of the ethanol extracts from aerial parts of K. paniculata and to screen their antioxidant and DNA-protective activity. HPLC profiling revealed the presence of five flavonoids, with rutin (4.23 mg/g DW), hesperidin (2.97 mg/g DW), and quercetin (2.66 mg/g DW) as the major ones in the leaves, and (−)-epicatechin (2.69 mg/g DW) in the flower buds. Among the nine phenolic acids identified, rosmarinic, p-coumaric, salicylic, vanillic, and gallic acids were the best represented. All the extracts tested showed in vitro antioxidant activity that was determined by DPPH, ABTS, FRAP, and CUPRAC assays. The highest activity was recorded in the flower parts (in the range from 1133 to 4308 mmol TE/g DW). The DNA-protective capacity of the flower and stem bark extracts from the in vitro nicking assay performed, as well as the main diagnostic microscopic features of the plant substances, are given for the first time. According to the results obtained, the aerial parts of K. paniculata could be valuable sources of natural antioxidants.

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“…Some examples of polyphenols with anti cancer effect are flavonoids such as quercetin, kaempferol, fisetin, myricetin (Myr), and phenolic acids such as gallic acid (GA), protocatechuic acid and rosmarinic acid [6,8,10,17]. Recent studies have demonstrated that Myr and GA particularly, could have interesting applications in the treatment of cancer [18,19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Gallic acid and Myricetin on ovarian cancer models: a possible alternative antitumoral treatment

Varela-Rodríguez

Sánchez‐Ramírez

Hernández‐Ramírez

et al. 2020

BMC Complement Med Ther

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Background: Ovarian cancer is the leading cause of mortality among malignant gynecological tumors. Surgical resection and chemotherapy with intravenous platinum/taxanes drugs are the treatments of choice, with little effectiveness in later stages and severe toxicological effects. Therefore, this study aimed to evaluate the antineoplastic activity of gallic acid (GA) and myricetin (Myr) administrated peritumorally in Nu/Nu mice xenotransplanted with SKOV-3 cells. Methods: Biological activity of GA and MYR was evaluated in SKOV-3 and OVCAR-3 cells (ovarian adenocarcinomas) by confocal/transmission electron microscopy, PI-flow cytometry, H 2-DCF-DA stain, MTT, and Annexin V/PI assays. Molecular targets of compounds were determined with ACD/I-Labs and SEA. Antineoplastic activity was performed in SKOV-3 cells subcutaneously xenotransplanted into female Nu/Nu mice treated peritumorally with 50 mg/kg of each compound (2 alternate days/week) for 28 days. Controls used were paclitaxel (5 mg/kg) and 20 μL of vehicle (0.5% DMSO in 1X PBS). Tumor lesions, organs and sera were evaluated with NMR, USG, histopathological, and paraclinical studies. Results: In vitro studies showed a decrease of cell viability with GA and Myr in SKOV-3 (50 and 166 μg/mL) and OVCAR-3 (43 and 94 μg/mL) cells respectively, as well as morphological changes, cell cycle arrest, and apoptosis induction due to ROS generation (p ≤ 0.05, ANOVA). In silico studies suggest that GA and MYR could interact with carbonic anhydrase IX and PI3K, respectively. In vivo studies revealed inhibitory effects on tumor lesions development with GA and MYR up to 50% (p ≤ 0.05, ANOVA), with decreased vascularity, necrotic/fibrotic areas, neoplastic stroma retraction and apoptosis. However, toxicological effects were observed with GA treatment, such as leukocyte infiltrate and hepatic parenchyma loss, hypertransaminasemia (ALT: 150.7 ± 25.60 U/L), and hypoazotemia (urea: 33.4 ± 7.4 mg/dL), due to the development of chronic hepatitis (p ≤ 0.05, ANOVA).

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Antioxidants: their health benefits and plant sources.

Cited by 22 publications

References 0 publications

Current knowledge and breeding perspectives for the miracle plant Synsepalum dulcificum (Schum. et Thonn.) Daniell

Current knowledge and breeding perspectives for the miracle plant Synsepalum dulcificum (Schum. et Thonn.) Daniell

Antioxidant and DNA-Protective Potentials, Main Phenolic Compounds, and Microscopic Features of Koelreuteria paniculata Aerial Parts

Effect of Gallic acid and Myricetin on ovarian cancer models: a possible alternative antitumoral treatment

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