Antioxidative activity of gold and platinum nanoparticles assessed through electron spin resonance

Kinoshita, Ângela; Lima, Iara Souza; Guidelli, Éder José; Baffa, Oswaldo

doi:10.26850/1678-4618eqj.v46.1si.2021.p68-74

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…Free radicals that lead to oxidative stress may cause biological damage, including slowing the healing process. Literature reports some investigations about the antioxidative potential of metal nanoparticles 11 important in the context of medical application. Thus, the new biomaterial with low-cost comprising AgNP aggregates all these properties, representing a good alternative.…”

Section: Introductionmentioning

confidence: 99%

Influence of silver nanoparticles on the tissue reaction of polyacrylic acid-based gel

Bonete

Tamashiro²,

Paiva³

et al. 2022

Acta Cir. Bras.

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Purpose: To study the influence of silver nanoparticles (AgNP) on tissue reaction when incorporated into a polymeric matrix of polyacrylic acid-based (Carbopol ® ) gel as a proposal for a new low-cost type of biomaterial that is simple to manufacture for use as an antimicrobial and antioxidative dressing. Methods: In-vivo tests of implantation in the subcutaneous tissue of the back of rats were performed using polyethylene tubes in three situations: empty, only the gel, and gel incorporated with AgNP. Then, the tissue reaction was studied by counting inflammatory cells. Additionally, in-vitro tests of the antioxidative and antimicrobial activity of AgNP were performed. The radical 2,2 diphenyl-1 picrylhydrazyl (DPPH) was used to test the antioxidative activity of AgNP using electron spin resonance. The antimicrobial activity of AgNP was determined by minimum inhibitory concentration against the microorganisms: Staphylococcus aureus , Pseudomonas aeruginosa , and Escherichia coli . Results: The results indicated that AgNP presents antioxidative activity and was able to inhibit the growth of the microorganisms tested. The addition of AgNP in Carbopol ® did not alter the tissue inflammatory response (p > 0.05, Kruskal-Wallis’s test). Conclusions: The new biomaterial is promising for future use as a dressing for its beneficial properties for regenerative processes.

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Section: Introductionmentioning

confidence: 99%

Influence of silver nanoparticles on the tissue reaction of polyacrylic acid-based gel

Bonete

Tamashiro²,

Paiva³

et al. 2022

Acta Cir. Bras.

Self Cite

View full text Add to dashboard Cite

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Platinum Nanoparticles: The Potential Antioxidant in the Human Lung Cancer Cells

2022

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Oxidative stress-related conditions associated with lung cells, specifically lung cancer, often lead to a poor prognosis. We hypothesized that platinum nanoparticles (PtNPs) can play a role in reversing oxidative stress in human lung adenocarcinoma A549 epithelial lung cell lines. Hydrogen peroxide (H2O2) was used to induce oxidative stress in cells, and the ability of PtNPs to lower the oxidative stress in the H2O2 treated epithelial lung cell line was determined. The differential capacity of PtNPs to remove H2O2 was studied through cell viability, nanoparticle uptake, DNA damage, ROS production, and antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). Results indicated that a higher concentration of PtNPs exhibited a higher antioxidant capacity and was able to reduce DNA damage and quench ROS production in the presence of 350 µM H2O2. All antioxidant enzymes’ activities also increased in the PtNPs treatment. Our data suggested that PtNPs could be a promising antioxidant in the treatment of lung cancer.

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Antioxidative activity of gold and platinum nanoparticles assessed through electron spin resonance

Cited by 2 publications

References 39 publications

Influence of silver nanoparticles on the tissue reaction of polyacrylic acid-based gel

Influence of silver nanoparticles on the tissue reaction of polyacrylic acid-based gel

Platinum Nanoparticles: The Potential Antioxidant in the Human Lung Cancer Cells

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