Antioxidative and Anti-inflammatory Activities of Carrot flower

김수경,; 변후돈,; 김상철,; 양경월,; 김정희,; 한종헌,

doi:10.7841/ksbbj.2015.30.2.77

Cited by 2 publications

(3 citation statements)

References 2 publications

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“…The concentration of NO in the culture media was determined through the Griess reaction (Kim et al, 2015).…”

Section: Measurement Of No (Nitric Oxide) Productionmentioning

confidence: 99%

“…In particular, suppressing the activity of matrix metalloproteinases (MMPs), the enzymes involved in the decomposition of collagen and elastin, is used as a criterion for assessing the efficacy of anti-wrinkling cosmetics (Jung et al, 2018;Lee et al, 2018), and for this reason, vitamin A derivatives and adenosine are notified by the Ministry of Food and Drug Safety as an anti-wrinkling agent (Kim et al, 2015;Lee et al, 2013). Schisandra chinensis fruit extract, vitamin E and ubiquinone are also known to have anti-wrinkling effects (Ahn et al, 2011;Kim et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Anti-Wrinkling Effect of Noni (Morinda citrifolia) by Antioxidant and Anti-Inflammatory Properties

Choi

Youn

2020

J. People Plants Environ

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Noni has been used for medicinal purposes for more than 2,000 years in South Pacific Polynesia, China and India, and has been heavily ingested as an extract for its excellent antioxidant and anti-inflammatory effects. However, a recent study found that the noni extract causes digestive disorders, kidney problems, and liver diseases, which made it necessary to use it for other purposes than as an extract. In this study, we want to evaluate the potential of noni as an anti-oxidant, anti-inflammatory and anti-wrinkling agent. Methods: Noni was freeze-dried, extracted in water, and concentrated. Skin cells were treated with the noni extract for 24 hrs and then were exposed to UVB (55 mJ/cm²). After 48 hrs of incubation, pro-inflammatory cytokine, elastase, MMP-1 and type-1 procollagen levels were measured by ELISA. Results: To find out the antioxidant effect of the noni extract, the DPPH and ABTS radical scavenging activity experiments were conducted and the noni extract showed 97.0 % and 92.0 % antioxidant efficacy at 200 μg/mL respectively. The noni extract (50 and 100 μg/mL) decreased IL-6 and TNF-α in RAW 264.7 cells induced by LPS in a concentration-dependent manner. In the RT-PCR experiment involving NO production, the noni extract (50 and 100 μg/mL) inhibited NO production by strongly inhibiting iNOS mRNA expression, and also inhibited the elevation of MMP-1 and elastases caused by UVB irradiation by 25.0 % and 7.0 % respectively. In addition, type-1 procollagen was elevated by 20.0 % by the noni extract treatment in HaCaT cells. Conclusion: The noni extract has photoprotective ability by reducing proinflammatory mediators, elastase and MMP-1 production, and elevation of collagen synthesis. Our findings suggest that the noni extract might be a good natural substance to protect against UVB-induced premature skin aging.

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“…The concentration of NO in the culture media was determined through the Griess reaction (Kim et al, 2015).…”

Section: Measurement Of No (Nitric Oxide) Productionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Wrinkling Effect of Noni (Morinda citrifolia) by Antioxidant and Anti-Inflammatory Properties

Choi

Youn

2020

J. People Plants Environ

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“…한국식품저장유통학회지 제24권 제7호 (2017) 1026 스가 항산화물질에 의해 감소되는 것이 알려지면서 항산화 물질을 개발하기 위한 연구들이 지속적으로 이루어지고 있으며, 합성 항산화제의 부작용이 증가함에 따라 천연물 유래의 항산화제에 관한 연구가 더욱 활발히 진행되고 있다 (10). 식물 유래의 2차 대사산물들은 자유유리기와 활성산 소의 생성을 억제하거나 제거시켜서 산화에 의한 세포손상 을 방지하는 것으로 알려져 있으며 (11,12), 천연물로부터의 radical 소거능을 확인하는 방법으로 1,1-diphenyl-2picrylhydrazyl(DPPH)와 2,2-azinobis(3-ethyl-benzothiazoline-6-sulfonic acid)(ABTS) assay가 널리 연구되어 지고 있다 (13).…”

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Antioxidant and anti-inflammatory activities of extracts from Ledum palustre L.

Kim¹

2017

Korean Journal of Food Preservation

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In this study, Ledum palustre L. was extracted by 4 different methods (LPW, hot water extraction; LPA, autoclave extraction; LPU, ultrasonification extraction; LPE, 70% ethanol extraction) and LPE was fractionated by using polarity difference of each solvent and used as 4 samples (LPE/H, the n-hexane layer; LPE/E, the EtOAc layer; LPE/B, the n-BuOH layer; LPE/W, the H2O layer). Antioxidant activities of Ledum palustre L. extracts were measured by DPPH and ABTS. As a result, the DPPH and ABTS radical scavenging showed high activities with LPE (82.3%, 99.8%) and LPE/E (91.8%, 99.6%) at the concentration of 1,000 μg/mL. The anti-inflammatory activities of LPE and LPE/E were measured by the inhibitory activity against NO, PGE2, TNF-α, IL-1β and IL-6 production on LPS-stimulated Raw 264.7 macrophages. As a result of MTT assay, cell viabilities of LPE and LPE/E were more than 90% at 25 μg/mL. NO and PGE2 productions were inhibited by LPE (NO: 50%, PGE2: 70%) and LPE/E (NO: 57%, PGE2: 73%) at the concentration of 25 μg/mL. The inhibition activities against TNF-α, IL-1β, IL-6 production were 24%, 47% and 40% at the concentration of 25 μg/mL of LPE. In particular, LPE/E showed 51%, 57% and 62% inhibition activities at the same concentration, respectively. From the above results, it can be concluded that 1,000 μg/mL of LPE and LPE/E have the high antioxidant activities similar with Vitamin C, and 25 μg/mL, the low concetration of LPE and LPE/E have excellent anti-inflammatory activities. Therefore, if more research about anti-aging, whitening and antimicrobial activity of Ledum palustre L. extracts is carried out in the future, it will be possible to use them as effective materials for the prevention and treatment of inflammatory diseases and in the areas of functional foods and cosmetics.

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Antioxidative and Anti-inflammatory Activities of Carrot flower

Cited by 2 publications

References 2 publications

Anti-Wrinkling Effect of Noni (Morinda citrifolia) by Antioxidant and Anti-Inflammatory Properties

Anti-Wrinkling Effect of Noni (Morinda citrifolia) by Antioxidant and Anti-Inflammatory Properties

Antioxidant and anti-inflammatory activities of extracts from Ledum palustre L.

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