Antioxidative and metabolic responses to extended cold exposure in rats

Yüksel, Şengül; Asma, Dilek; Yeşilada, Özfer

doi:10.1556/abiol.59.2008.1.5

Cited by 23 publications

(14 citation statements)

References 34 publications

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“…It was observed that cold stress exposure increased lipid depletion in adrenal gland and glycogen depletion in hepatocytes, which supports previous studies [5,6]. We noted that this NMDA antagonist, currently used to treat subjects with moderate to severe Alzheimer's disease [4,5], significantly attenuated glycogen and lipid depletion in liver and adrenal gland, respectively, caused by cold stress in health Wistar rats.…”

Section: Discussionsupporting

confidence: 90%

“…Histological slides were reviewed by a pathologist. Previous publications validated this procedure [5,6,19]. …”

Section: Methodsmentioning

confidence: 91%

“…Cold stress was performed only once. Rat's temperature was controlled at approximately 37°C and the behavior of the animals was observed during all the procedures [5,6,15,16]. …”

Section: Methodsmentioning

confidence: 99%

“…Induced cold state by low temperature exposure is considered as an important stressing physical agent [6]. Previous studies reported that acute exposure to cold stress besides impair heart tissue [7-9] cause lipid depletion in adrenal gland and glycogen depletion in liver [10], suggesting that the sympathetic activity and oxidative stress are the source of such fact.…”

Section: Introductionmentioning

confidence: 99%

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Memantine effects on liver and adrenal gland of rats exposed to cold stress

et al. 2011

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BackgroundMemantine attenuates heart stress due cold stress, however, no study focused its effects on liver and adrenal gland. We evaluated its effects on lipid depletion in adrenal gland and glycogen depletion in liver of rats exposed to cold stress.MethodsMale rats divided into 4 groups: 1)Control (CON); 2)Memantine (MEM); 3)Induced cold stress (IH) and; 4)Induced cold stress memantine (IHF). Memantine were administrated by gavage (20 mg/kg/day) during eight days. Cold stress were performed during 4 hours once at - 8°C. Lipid and glycogen depletion were presented as its intensity levels.ResultsRats exposed to cold stress presented the highest glycogen (p < 0.001) and lipid depletion (p < 0.001) in liver and adrenal gland, respectively. We noted that memantine significantly reduced lipid depletion in adrenal gland and glycogen depletion in liver.ConclusionMemantine prevented glycogen depletion in liver and lipid depletion in adrenal gland of rats under a cold stress condition.

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Section: Discussionsupporting

confidence: 90%

“…Histological slides were reviewed by a pathologist. Previous publications validated this procedure [5,6,19]. …”

Section: Methodsmentioning

confidence: 91%

“…Cold stress was performed only once. Rat's temperature was controlled at approximately 37°C and the behavior of the animals was observed during all the procedures [5,6,15,16]. …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Memantine effects on liver and adrenal gland of rats exposed to cold stress

et al. 2011

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“…Exposure to low temperatures is considered to be an important stressing physical agent 4,5. Previous studies have reported that acute exposure to cold stress can damage heart tissue6 and cause lipid depletion in the adrenal gland and glycogen depletion in the liver,6–8 thus suggesting that sympathetic activity and oxidative stress are the sources of these injuries.…”

Section: Introductionmentioning

confidence: 99%

Electric Countershock and Cold Stress Effects on Liver and Adrenal Gland

Ferreira

Abreu

Valenti

et al. 2010

Clinics

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OBJECTIVES:Cold exposure induces glycogen and lipid depletion in the liver and the adrenal gland, respectively. However, no previous study has determined the effects of electrical countershock on those tissues. We aimed to evaluate the effects of electrical countershock on lipid depletion in the adrenal gland and on glycogen depletion in the liver.METHODS:We used 40 male Wistar rats divided into four groups: the control group, in which the animals were subjected to a resting period of seven days; the electrical discharge group, in which the animals were subjected to a resting period followed by administration of ten 300-mV electrical discharges; the electrical post-discharge group, in which the animals received ten electrical shocks (300 mV) followed by rest for seven consecutive days; and the cold stress group, in which the animals were subjected to a resting period and were then exposed to −8ºC temperatures for four hours. All animals underwent a laparotomy after treatment. The lipid and glycogen depletions are presented using intensity levels (where + = low intensity and ++++ = high intensity, with intermediate levels in between).RESULTS:The rats exposed to the cold stress presented the highest glycogen and lipid depletion in the liver and the adrenal gland, respectively. Furthermore, we noted that the electrical countershock significantly increased lipid depletion in the adrenal gland and glycogen depletion in the liver. One week after the electrical countershock, the liver and adrenal gland profiles were similar to that of the control group.CONCLUSION:Electrical countershock immediately increased the glycogen depletion in the liver and the lipid depletion in the adrenal gland of rats.

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Isolation of AccGalectin1 from Apis cerana cerana and its functions in development and adverse stress response

Wang

Han

et al. 2018

J of Cellular Biochemistry

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The galectins are a family of lectins that play important roles in development, immunity, and the regulation of cellular responses. Much research has focused on the functions of galectins in mammals, though less in insects. Here, we identified the AccGalectin1 gene in Apis cerana cerana for the first time and explored its functions. The open reading frame of AccGalectin1 is 1449 base pairs and encodes a 482-amino-acid protein. AccGalectin1 expression was high during the transition between developmental stages and was high in the head, thorax, and epidermis compared with its levels in other tissues. In addition, the expression of AccGalectin1 was induced by several adverse stresses, including both abiotic and biotic stresses. A disk diffusion assay of recombinant AccGalectin1 protein revealed possible roles in protecting cells from oxidative stress. Furthermore, the expression levels of multiple oxidative genes (AccCAT, AccTpx1, AccTrx2, etc) were increased after AccGalectin1 was knocked down in Apis cerana cerana using RNA interference. We also observed that the malondialdehyde content in the AccGalectin1-silenced bees was higher than that in the control bees, while the antioxidant enzymatic activities of superoxide dismutase and peroxidase were lower. Considering these results, we suggest that AccGalectin1 may be indispensable for protecting honeybees from biotic and abiotic damage by participating in the oxidative resistance response and the immune response. These results may provide insight into the precise functions of galectins in mammals and other insects.

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Antioxidative and metabolic responses to extended cold exposure in rats

Cited by 23 publications

References 34 publications

Memantine effects on liver and adrenal gland of rats exposed to cold stress

Memantine effects on liver and adrenal gland of rats exposed to cold stress

Electric Countershock and Cold Stress Effects on Liver and Adrenal Gland

Isolation of AccGalectin1 from Apis cerana cerana and its functions in development and adverse stress response

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