Antioxidative and Photo-Induced Effects of Different Types of N-Doped Graphene Quantum Dots

Abstract

Due to the increasing number of bacterial infections and the development of resistivity toward antibiotics, new materials and approaches for treatments must be urgently developed. The production of new materials should be ecologically friendly considering overall pollution with chemicals and economically acceptable and accessible to the wide population. Thus, the possibility of using biocompatible graphene quantum dots (GQDs) as an agent in photodynamic therapy was studied. First, dots were obtained using electrochemical cutting of graphite. In only one synthetic step using gamma irradiation, GQDs were doped with N atoms without any reagent. Obtained dots showed blue photoluminescence, with a diameter of 19–89 nm and optical band gap of 3.23–4.73 eV, featuring oxygen-containing, amino, and amide functional groups. Dots showed antioxidative activity; they quenched •OH at a concentration of 10 μg·mL−1, scavenged DPPH• radicals even at 5 μg·mL−1, and caused discoloration of KMnO4 at 30 μg·mL−1. Under light irradiation, dots were able to produce singlet oxygen, which remained stable for 10 min. Photoinduced effects by GQDs were studied on several bacterial strains (Listeria monocytogenes, Bacillus cereus, clinical strains of Streptococcus mutans, S. pyogenes, and S. sangunis, Pseudomonas aeruginosa, and one yeast strain Candida albicans) but antibacterial effects were not noticed.

Effect of defects on optical and electronic properties of graphene quantum dots: a density functional theory study

“…31 Moreover, some studies have reported that defects induced heteroatom doping, such as nitrogen and sulfur dopants, can reduce the band gap of GQDs, leading to improve light absorption and prolonged luminescence lifetime. 24,[32][33][34][35][36][37][38] In addition, the presence of defects in GQDs has been exploited for specic applications. For example, Wang et al develop a carbon-based non-metallic catalyst using defect-rich GQDs, and the catalytic performance of this catalyst depends on the defect density, showing potential for anti-cancer applications.…”