Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice

Abstract

Obesity is a worldwide epidemic that is characterized not only by excessive fat deposition but also by systemic microinflammation, high oxidative stress, and increased cardiovascular risk factors. While diets enriched in natural antioxidants showed beneficial effects on oxidative stress, blood pressure, and serum lipid composition, diet supplementation with synthetic antioxidants showed contradictive results. Thus, we tested in C57Bl/6 mice whether a daily dosage of an antioxidative mixture consisting of vitamin C, vitamin E, L-arginine, eicosapentaenoic acid, and docosahexaenoic acid (corabion) would affect cardiovascular risk factors associated with obesity. Obese mice showed increased serum triglyceride and glucose levels and hypertension after eight weeks of being fed a high-fat diet (HFD). Importantly, corabion ameliorated all of these symptoms significantly. Oxidative stress and early signs of systemic microinflammation already developed after two weeks of high-fat diet and were significantly reduced by daily doses of corabion. Of note, the beneficial effects of corabion could not be observed when applying its single antioxidative components suggesting that a combination of various nutrients is required to counteract HFD-induced cardiovascular risk factors. Thus, daily consumption of corabion may be beneficial for the management of obesity-related cardiovascular complications.

Effects of replacing wheat flour with detoxified ginkgo nut powder on lipid metabolism of obese C57BL/6J male mice

“…The main causes of obesity are the excessive consumption of calories and the lack of physical activity (Vargas-Robles, Rios, Arellano-Mendoza, Escalante, & Schnoor, 2015). Hyperlipidaemia caused by a dysregulation in lipid metabolism is a critical feature of obesity and is strongly associated with metabolic disorders (Vargas-Robles et al, 2015). Food intake control and diet are crucial in obesity prevention and treatment (Botezelli et al, 2010).…”

High-fat diet intake from senescence inhibits the attenuation of cell functions and the degeneration of villi with aging in the small intestine, and inhibits the attenuation of lipid absorption ability in SAMP8 mice

“…It is also known that high-fat diet negatively affects circulatory system in common with inducing fatty liver and diabetes. ( 57 ) So, it is interesting that high-fat diet intake from senescence has influence on cardiovascular parameter. However, in this study, we did not examine cardiovascular parameters because the ability of gastrointestinal tract to lipid was the most important element.…”

High fat diet confers vascular hyper-contractility against angiotensin II through upregulation of MLCK and CPI-17

“…RAAS plays a critical role in the elevation of blood pressure via regulating vascular contractility and blood volume [4]. High fat diet (HFD)-induced hypertension is established animal model to study renal and cardiovascular factors for the obesity-related hypertension [5678]. There are lines of evidence that inhibition of Ang II prevents HFD-induced hypertension [9].…”