Antioxidative Effect and Tyrosinase Inhibitory Activity of Lindera obtusiloba Blume Extracts

원두현,; 한샛별,; 황준필,; 김수지,; 박진오,; 박수남,

doi:10.15230/scsk.2012.38.4.297

Cited by 14 publications

(6 citation statements)

References 15 publications

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“…α-arbutin is usually produced by transglucylation of hydroquinone by microbial glycosyltransferase (Zhu X et al, 2018) [23]. Studies have indicated that arbutin can prevent tyrosinase activity, thereby preventing melanin production and reducing skin pigmentation (Won et al, 2012;Chunhakant and Chaicharoenpong, 2019;Ye et al, 2019;Zhang et al, 2022) [24][25][26][27]. Recent studies have shown that α-Arbutin shows potential anti-photoaging effects, likely linked to diminished cellular inflammation from IL-6 and TNF-α (Hazman Ö et al, 2021;Lee et al, 2012) [28,29].…”

Section: Introductionmentioning

confidence: 99%

The Effect of α-Arbutin on UVB-Induced Damage and Its Underlying Mechanism

Shu,

Wang,

Zhang

2024

Molecules

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Ultraviolet radiation can heighten tyrosinase activity, stimulate melanocyte production, impede the metabolism of numerous melanocytes, and result in the accumulation of plaques on the skin surface. α-Arbutin, a bioactive substance extracted from the arbutin plant, has been widely used for skin whitening. In this study, the whitening effect of α-arbutin by inhibiting tyrosinase activity and alleviating the photoaging effect induced by UVB are investigated. The results indicate that α-arbutin can inhibit skin inflammation, and its effectiveness is positively correlated with concentration. Moreover, α-arbutin can reduce the skin epidermal thickness, decrease the number of inflammatory cells, and down-regulate the expression levels of IL-1β, IL-6 and TNF-α, which are inflammatory factors. It also promotes the expression of COL-1 collagen, thus playing an important role in anti-inflammatory action. Network pharmacology, metabolomics and transcriptomics further confirm that α-arbutin is related to the L-tyrosine metabolic pathway and may interfere with various signaling pathways related to melanin and other photoaging by regulating metabolic changes. Therefore, α-arbutin has a potential inhibitory effect on UVB-induced photoaging and possesses a whitening effect as a cosmetic compound.

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Section: Introductionmentioning

confidence: 99%

The Effect of α-Arbutin on UVB-Induced Damage and Its Underlying Mechanism

Shu,

Wang,

Zhang

2024

Molecules

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“…L. obtusiloba has been used as herbal medicine for improving blood circulation and treating inflammation [ 33 ]. Previous studies demonstrated that the extract of L. obtusiloba has potent anti-oxidative and anti-inflammatory activities on atopic dermatitis and anti-allergic responses in mast cells [ 33 , 34 , 35 , 36 ]. In detail, L. obtusiloba has effects such as anti-inflammation and anti-allergy through the suppression of histamines and Th2 cytokines in a DFE/DNCB-induced atopic dermatitis model [ 34 ].…”

Section: Introductionmentioning

confidence: 99%

“…In detail, L. obtusiloba has effects such as anti-inflammation and anti-allergy through the suppression of histamines and Th2 cytokines in a DFE/DNCB-induced atopic dermatitis model [ 34 ]. On the other hand, L. obtusiloba inhibited ROS generation in the Fe 3+ -EDTA/H 2 O 2 system, and has potent 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical scavenging activity [ 35 ]. Although many studies have reported the anti-oxidant and anti-inflammatory properties of L. obtusiloba , its protective effects of allergic asthma have not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

Lindera obtusiloba Attenuates Oxidative Stress and Airway Inflammation in a Murine Model of Ovalbumin-Challenged Asthma

Lee

Shin

et al. 2020

Antioxidants

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Lindera obtusiloba is widespread in northeast Asia and used for treatment of improvement of blood circulation and anti-inflammation. In this study, we investigated anti-inflammatory and anti-oxidant effects of the methanolic extract of L. obtusiloba leaves (LOL) in an ovalbumin (OVA)-challenged allergic asthma model and tumor necrosis factor (TNF)-α-stimulated NCI-H292 cell. Female BALB/c mice were sensitized with OVA by intraperitoneal injection on days 0 and 14, and airway-challenged with OVA from days 21 to 23. Mice were administered 50 and 100 mg/kg of LOL by oral gavage 1 h before the challenge. LOL treatment effectively decreased airway hyper-responsiveness and inhibited inflammatory cell recruitment, Th2 cytokines, mucin 5AC (MUC5AC) in bronchoalveolar lavage fluid in OVA-challenged mice, which were accompanied by marked suppression of airway inflammation and mucus production in the lung tissue. LOL pretreatment inhibited the phosphorylation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) with suppression of activator protein (AP)-1 and MUC5AC in the lung tissue. LOL also down-regulated expression of inflammatory cytokines, and inhibited the activation of NF-κB in TNF-α-stimulated NCI-H292 cells. LOL elevated the translocation of nuclear factor-erythroid 2-related factor (Nrf-2) into nucleus concurrent with increase of heme oxyngenase-1 (HO-1) and NAD(P)H quinine oxidoreductase 1 (NQO1). Moreover, LOL treatment exhibited a marked increase in the anti-oxidant enzymes activities, whereas effectively suppressed the production of reactive oxygen species and nitric oxide, as well as lipid peroxidation in lung tissue of OVA-challenged mice and TNF-α-stimulated NCI-H292 cells. These findings suggest that LOL might serve as a therapeutic agent for the treatment of allergic asthma.

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“…생강나무를 이용한 국내연구는 gas chromatography mass spectrometry를 이용한 계절에 따른 생강나무의 부위별 향기 성 분 비교 분석 (Hwang et al, 2005), 제조방법에 따른 생강나무 잎 차의 성분변화 (Hwang et al, 2003), 제조방법에 다른 생강나무 잎차의 향기 성분의 변화 (Hwang et al, 2005), 잎과 가지의 정유 성분 (Kwon et al, 2007) 등이 있으며, 기능성 식품 및 화장품 소 재로서의 연구로는 식중독균에 대한 항균 활성 (Kim et al, 2014), 암 전이 억제 효과 (Yun et al, 2012), 항산화 효과 및 티로시나 아제 저해 활성 (Won et al, 2012), 광노화에 의한 주름형성 억제 효과 (Park et al, 2009), 잎 및 가지 추출물의 생리 활성 (Hong, 2013), 알레르기성 염증반응 억제 효과 (Kim et al, 2009), 항산화 활성과 미백 효과 (Bang et al, 2008) To confirm the whitening effects of L. obtusiloba flower extracts, we measured tyrosinase activity in B16F10 melanoma cells. Both LWE and LEE decreased the tyrosinase activity in a dosedependent manner.…”

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Applicability of Lindera obtusiloba Flower Extracts as Cosmetic Ingredients

Yu¹,

Kim²

2017

Asian J Beauty Cosmetol

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Purpose: This study confirms the cosmeceutical effects of the Lindera obtusiloba (L. obtusiloba) flower and its applicability as a natural cosmetic ingredient. Methods: After obtaining the extracts from the L. obtusiloba flower using hot water and 70% ethanol, its anti-oxidation, whitening, wrinkle improvement, and anti-bacterial properties were measured. Results: The ethanol extracts from the L. obtusiloba flower had a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effects of 81.33% at 500 µg/mL and contained phenol and flavonoid concentrations of 152.00 and 145.27 µg/mL, respectively, which were higher than those seen in the hot water extracts. With respect to the whitening effects of the L. obtusiloba flower, the ethanol extracts suppressed tyrosinase enzyme activity by 31.00% at a concentration of 500 µg/mL. In B16F10 melanoma cells, the extracts showed excellent inhibitory effects on tyrosinase and melanin biosynthesis. Its inhibitory effects on α-melanocyte-stimulating hormone (α-MSH)-induced tyrosinase activity and melanin biosynthesis were higher than those observed using the positive control, arbutin. The measurement of procollagen synthesis confirmed the wrinkle improvement effects of the L. obtusiloba flower, with the ethanol extracts promoting a 130.00% increase in procollagen biosynthesis. The anti-bacterial effects of the L. obtusiloba flower extracts on Staphylococcus epidermidis (S. epidermidis), Staphylococcus aureus (S. aureus), and Propionibacterium acnes (P. acnes) were assessed. Here the ethanol extracts had the greatest anti-bacterial effects on S. epidermidis and P. acnes. Conclusion: L. obtusiloba flower extracts are expected to be highly applicable as natural functional cosmetics of material having skin whitening, wrinkle improvement, and anti-bacterial effects.

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Antioxidative Effect and Tyrosinase Inhibitory Activity of Lindera obtusiloba Blume Extracts

Cited by 14 publications

References 15 publications

The Effect of α-Arbutin on UVB-Induced Damage and Its Underlying Mechanism

The Effect of α-Arbutin on UVB-Induced Damage and Its Underlying Mechanism

Lindera obtusiloba Attenuates Oxidative Stress and Airway Inflammation in a Murine Model of Ovalbumin-Challenged Asthma

Applicability of Lindera obtusiloba Flower Extracts as Cosmetic Ingredients

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