Applicability of Lindera obtusiloba Flower Extracts as Cosmetic Ingredients

Abstract

Purpose: This study confirms the cosmeceutical effects of the Lindera obtusiloba (L. obtusiloba) flower and its applicability as a natural cosmetic ingredient. Methods: After obtaining the extracts from the L. obtusiloba flower using hot water and 70% ethanol, its anti-oxidation, whitening, wrinkle improvement, and anti-bacterial properties were measured. Results: The ethanol extracts from the L. obtusiloba flower had a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effects of 81.33% at 500 µg/mL and contained phenol and flavonoid concentrations of 152.00 and 145.27 µg/mL, respectively, which were higher than those seen in the hot water extracts. With respect to the whitening effects of the L. obtusiloba flower, the ethanol extracts suppressed tyrosinase enzyme activity by 31.00% at a concentration of 500 µg/mL. In B16F10 melanoma cells, the extracts showed excellent inhibitory effects on tyrosinase and melanin biosynthesis. Its inhibitory effects on α-melanocyte-stimulating hormone (α-MSH)-induced tyrosinase activity and melanin biosynthesis were higher than those observed using the positive control, arbutin. The measurement of procollagen synthesis confirmed the wrinkle improvement effects of the L. obtusiloba flower, with the ethanol extracts promoting a 130.00% increase in procollagen biosynthesis. The anti-bacterial effects of the L. obtusiloba flower extracts on Staphylococcus epidermidis (S. epidermidis), Staphylococcus aureus (S. aureus), and Propionibacterium acnes (P. acnes) were assessed. Here the ethanol extracts had the greatest anti-bacterial effects on S. epidermidis and P. acnes. Conclusion: L. obtusiloba flower extracts are expected to be highly applicable as natural functional cosmetics of material having skin whitening, wrinkle improvement, and anti-bacterial effects.

Analysis of the genetic diversity and population structure of Lindera obtusiloba (Lauraceae), a dioecious tree in Korea

“…Kim et al (2015) reported that methanolic extract of L. obtusiloba had a lifespan-extending effect in a model organism, Caenorhabditis elegans, by increasing antioxidant enzyme activities, thereby reducing intracellular reactive oxygen species levels. Many efforts also have been made to use L. obtusiloba extracts as functional cosmetic ingredients (Bang et al 2008;Park et al 2009;Won et al 2012;Yu and Kim 2017).…”

Anti-oxidant activity and protective effects of Lindera obtusiloba flower teas on inflammatory response in Raw 264.7 macrophages induced by lipopolysaccharide

“…생강나무 잎, 줄기 등의 지상부는 알레르기 개선, 신경세포 보호, 염증 개선 및 간 보호 효과 등 다양한 생리활성이 보고되어 기능성 소재 로서의 가능성이 보고되었다 [15][16][17]. 반면 생강나무 꽃은 미백, 주름 개선 등 화장품 소재로 이용 관련 연구, Saccharomycopsis fibuligera로 발효시킨 생강나무 꽃의 항산화 및 항염증 활성 관 련 일부 연구만이 보고되었다 [18,19]. 생강나무 꽃에는 quercetin-3-O-α-L-rhamnopyranoside, quercetin-3-O-β-L-galacto-pyranoside와 같은 플라보노이드 배당체를 함유하고 있어 항산 화 및 항염증 기능성 소재로서의 활용 가능성이 높을 것으로 사료된다 [20].…”

Biological Activity Study on Anti-oxidant, Whitening, and Anti-inflammatory Effects of Astragalus membranaceus Ethanol Extracts and Bioconversion Extracts

“…최근 천연 소재를 활용한 기능성 화장품의 소재 개발 연구가 진행되고 있으며 (Ha & You, 2016;Han et al, 2016;Yu & Kim, 2017) (Lim et al, 2003 Tween 20, pH 7.5)]에 희석한 β-actin primary antibody…”