Biological Activity Study on Anti-oxidant, Whitening, and Anti-inflammatory Effects of Astragalus membranaceus Ethanol Extracts and Bioconversion Extracts

Bae, Hye-Kyung; You, Seon-Hee

doi:10.20402/ajbc.2017.0167

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…없는 천연 물질에 대한 관심도가 증가하고 있으며, 이에 따라 한 약재인 황기 11) , 황련 12) , 병풀 13) , 승마 14) 등의 추출물을 이용한 연구 가 활발히 이루어지고 있다. 보고에 따르면, 여성 호르몬인 에스트 로겐은 유방암 발생에 중요한 역할을 하는데, 호르몬 대체 요법으 로 사용되는 승마 추출액이 유방암 세포의 증식을 억제하는 것으 로 보고되고 있다 15) .…”

Section: 최근 상대적으로 인체에 안전하며 약물에 의한 부작용이 거의unclassified

Effect of apoptosis on G361 cells byCimicifuga rhizomaextract

Choi¹,

Kim

Hong

et al. 2019

J Korean Acad Oral Health

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Objectives: To investigate whether the cytotoxic effect of Cimicifuga rhizoma extract is associated with cell death in the human keratinocyte (HaCaT) and human melanoma cell lines (G361). Methods: Apoptosis induced by Cimicifuga rhizoma extract was confirmed by water-soluble tetrazolium salts-1 (WST-1) assay, immunocytochemistry, and western blot. Additionally, the release of cytochrome c and apoptosis-inducing factor (AIF) was visualized by confocal laser scanning microscopy. Results: The results showed that Cimicifuga rhizoma extract significantly reduced the viability of G361 cells with half-maximal inhibitory concentration (IC 50) of 200 mg/ml, and the apoptotic process was found to occur via the activation of caspase-3 and caspase-9 pathways. Besides, the release of cytochrome c and AIF was also detected. Conclusions: This study suggests that Cimicifuga rhizoma extract causes apoptosis of human melanoma cells through the intrinsic apoptotic pathway.

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Section: 최근 상대적으로 인체에 안전하며 약물에 의한 부작용이 거의unclassified

Effect of apoptosis on G361 cells byCimicifuga rhizomaextract

Choi¹,

Kim

Hong

et al. 2019

J Korean Acad Oral Health

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“…http://dx.doi.org/10.20402/ajbc.2018.0221 포 조직에 어떠한 기질적 변화를 가져오는 침습이 가해질 때, 생 체가 재생이나 회복 등을 하기 위한 방어적 반응으로 나타나는 것 이다. 이 과정에서 활성 산소종(reactive oxygen species)의 일종 인 nitric oxide (NO)는 대식 세포와 같은 면역세포에 의해 생성 되어 각종 생리 및 병리적 과정에 있어 중요한 역할을 한다 (Lee et al, 2007 (Bae & You, 2017). 고마리(Persicaria thunbergii, P. thunbergii)의 국내 연구로 는 lipopolysaccharide (LPS)로 처리 된 RAW 264.7 세포에서 고 마리 추출물의 항염증 효과 (Kim et al, 2011a), persicarin과 quercitrin 등 고마리의 항산화 활성성분에 대한 보고가 있다 (Lee et al, 2001).…”

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“…또한 천연 복합물의 항산화 (Kim et al, 2011b) 및 생리 활성이나 화장품 소재 연구로는, 참당귀 연구에서 quercetin 이 강한 생리활성으로 보고 되었고 (Moon et al, 2000), 황금 지 상부의 항산화 및 알러지 활성 성분 (Cha et al, 2006)에서 지질 과산화에 대한 억제효과를 나타냈다. 그리고 파슬리 지상부의 항 산화 활성성분 (Choi & Moon, 2017), 갈퀴나물 지상부 에탄올 추 출물의 항산화 및 항주름 효과 (Kim et al, 2015), 황기에탄올 추 출물 및 생물전환 추출물의 항산화, 항염증 효과에 대한 생리활성 (Bae & You, 2017) (Figure 2).…”

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Persicaria thunbergii Extract as a Physiologically Active Cosmetic Ingredient

Gwak¹,

Kim²

2018

Asian J Beauty Cosmetol

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Purpose: The purpose of this study was to investigate the potential of Persicaria thunbergii (P. thunbergii) extracts as physiologically active cosmetic ingredients. Methods: To elucidate the anti-oxidative, anti-inflammatory, and anti-microbial properties of P. thunbergii , its ethanol and hot-water extracts were examined for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, nitric oxide (NO) production, protective effects against oxidative stress in HaCaT cells, antiinflammatory activity, anti-microbial activity, and inhibition of β-hexosaminidase expression, an allergy factor. Results: The anti-oxidative activity of the two P. thunbergii extracts was compared, and the anti-oxidative activity of the ethanol extract was found to be superior to that of the hot-water extract. The polyphenol contents of P. thunbergii ethanol and hot-water extracts were 132.00 and 89.46 μg/ mL, respectively. And total flavonoid contents of P. thunbergii ethanol and hot-water extracts were 115.27, 84.94 μg/mL, respectively. The DPPH radical scavenging activity was found to be 79.80% for the ethanol extract and 70.33% for the hot-water extract at a concentration of 500 μg/mL. No significant cytotoxicity was observed in HaCaT, RAW 264.7 and RBL-2H3 cells. The protective effect of the extracts on HaCaT cell against oxidative stress induced by hydrogen peroxide (H 2 O 2) was confirmed by 23% for ethanol extract and 18% for hot water extract. The anti-inflammatory activity of the extracts was examined in RAW 264.7 cells, and nitric oxide (NO) production was suppressed in a concentration-dependent manner. Both ethanol and hotwater extracts also inhibited the degranulation of immune cells in a concentrationdependent manner, as assessed by the secretion of β-hexosaminidase. In addition, the concentration dependent anti-microbial activities of the extracts were demonstrated in several bacterial strains, such as those of Staphylococcus aureus (S. aureus), Staphylococcus epidermidis (S. epidermidis), and Propionibacterium acnes (P. acnes). Conclusion: Based on the findings from this study, P. thunbergii extracts could be used as functional cosmetic ingredients that possess anti-oxidative, antiinflammatory, and anti-microbial properties. In order to determine their applicability, further research should be systematically conducted to verify their efficacy through clinical studies in animals and humans.

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Antioxidant Effects of Ponciri Fructus Bioconversion Extracts as Cosmetic Ingredients

Kong¹,

Kwon²

2021

Asian J Beauty Cosmetol

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Purpose: This study was conducted to investigate the possible use of Ponciri fructus bioconversion extracts as cosmetic ingredients.Method: Total polyphenol, total flavonoid content, and antioxidant effects of Poncirus trifoliata through the ability of diphenylpicrylhydrazyl (DPPH) radical scavenging were used for antioxidant activity determination. The extracts of Poncirus trifoliata were analyzed using an ultraviolet–visible spectrophotometerResults: The total phenolic content was 62.5±4.19 gallic acid equivalent (GAE) mg/g in the case of alcohol extracts and 82.8±2.55 GAE mg/g for other bioconversion extracts. Therefore, total flavonoids content was found to have increased by 32.4%. The total flavonoid content of ethanol extracts was 30.1±3.15 mg/g, whereas that of other bioconversion extracts was 39.5±35.1 mg/g. Therefore, total flavonoids increased by 31.2%. From DPPH radical results, the alcoholic extract increased from 65.5% to 75.5% after bioconversion. Thus, the bioconversion extracts increased by 10% compared with ethanol extracts.Conclusion: Poncirus trifoliata has excellent antioxidant effects, and it showed increased antioxidant activity after the bioconversion, thereby demonstrating its functional bioutility. Therefore, it can be used as an antioxidant material in the cosmetic and food industry.

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Biological Activity Study on Anti-oxidant, Whitening, and Anti-inflammatory Effects of Astragalus membranaceus Ethanol Extracts and Bioconversion Extracts

Cited by 4 publications

References 8 publications

Effect of apoptosis on G361 cells byCimicifuga rhizomaextract

Effect of apoptosis on G361 cells byCimicifuga rhizomaextract

Persicaria thunbergii Extract as a Physiologically Active Cosmetic Ingredient

Antioxidant Effects of Ponciri Fructus Bioconversion Extracts as Cosmetic Ingredients

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