Antioxidative Effect of Citrus Essential Oil Components on Human Low-density Lipoprotein<i>In Vitro</i>

Takahashi, Yasuo; Inaba, Nobuya; Kuwahara, Shigeru; Kuki, Wataru

doi:10.1271/bbb.67.195

Cited by 53 publications

(26 citation statements)

References 16 publications

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“…In addition to the phenolic constituents, the monoterpene hydrocarbon γ-terpinene, was also found to inhibit LDL oxidation, even in the propagation phase. γ-Terpinene generated an antioxidative effect on the Cu 2+ -induced and AAPHinduced oxidation of human LDL in vitro (Takahashi et al, 2003). Tea tree essential oil is considered to be a rich source of γ-terpinene (23.0%) (Brophy et al, 1989) and γ-terpinene is also found in considerable amounts in some citrus peel essential oils such as bergamot (14%), mandarin (17%) and lemon (10%) (Mondello et al, 1995).…”

Section: Essential Oils and Cardiovascular Diseases Atherosclerosismentioning

confidence: 99%

Pharmaceutical and therapeutic Potentials of essential oils and their individual volatile constituents: a review

Edris

2007

Phytotherapy Research

1,095

688

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Essential oils and their volatile constituents are used widely to prevent and treat human disease. The possible role and mode of action of these natural products is discussed with regard to the prevention and treatment of cancer, cardiovascular diseases including atherosclerosis and thrombosis, as well as their bioactivity as antibacterial, antiviral, antioxidants and antidiabetic agents. Their application as natural skin penetration enhancers for transdermal drug delivery and the therapeutic properties of essential oils in aroma and massage therapy will also be outlined.

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Section: Essential Oils and Cardiovascular Diseases Atherosclerosismentioning

confidence: 99%

Pharmaceutical and therapeutic Potentials of essential oils and their individual volatile constituents: a review

Edris

2007

Phytotherapy Research

1,095

688

View full text Add to dashboard Cite

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“…[18] This compound and essential oils containing a signifi cant amount of this terpene are used as fl avourings for food additives, fragrances in cosmetics and scents in household products, such as soaps, disinfectants and detergents. [19] g-Terpinene is a monoterpene widely distributed in essential oils, especially in Citrus oils, and it has been found to exert a strong antioxidative eff ect on human lowdensity lipoproteins (LDLs) in vitro, [20] also by potentiating the eff ects of other natural antioxidants, such as rutin and ascorbic acid. [21] Thanks to its capacity to inhibit the peroxidation of lipids, g-terpinene-containing essential oil represents a valid alternative to vitamin E for obtaining large increases in the oxidative stability and shelf-life of edible lipids.…”

Section: Resultsmentioning

confidence: 99%

Chemical composition and antimicrobial activity of the essential oil of Ferulago campestris (Besser) Grecescu growing in central Italy

Maggi

Tirillini

Papa

et al. 2009

Flavour & Fragrance J

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Essential oil from the fl owers and leaves of Ferulago campestris (Apiaceae) from two collection sites in central Italy was analysed by GC-FID and GC-MS and 134 constituents were identifi ed and quantifi ed by calculating the response factors of FID. Monoterpene hydrocarbons constituted the main fraction of the fl ower oils, with a-pinene, myrcene and g-terpinene as the major components. Sesquiterpenes gave the major contribution to the essential oils from the leaves, with the oxygenated components more abundant, a-humulene, spathulenol and caryophyllene oxide being the most representative. The antimicrobial activity (as inhibition zone and MIC) of the essential oils from fl owers was evaluated, using a panel of human opportunistic pathogenic bacteria and fungi, by the agar disc diff usion and broth microdilution methods: the Gram-positive Bacillus subtilis (MIC = 155-310 mg/ml) and Enterococcus faecalis (MIC = 310 mg/ml), and the Gram-negative Escherichia coli (MIC = 310-625 mg/ml) were found to be the most susceptible strains.

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“…15) There are several reports on the antioxidant effects of terpenoids. 13,22) These terpenoids and their combinations might also be important factors responsible for the enhanced inhibition of tyrosinase activity and melanin biosynthesis in B-16 melanoma cells and a human reconstructed skin model. In summary, this study suggests that four types (the A-type, AB-type, D-type, and G-type) of phytoncide solution showed inhibitory effects on tyrosinase activity and melanin biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Phytoncide Solution on Melanin Biosynthesis

Fujimori

Hisama

Shibayama

et al. 2010

Bioscience, Biotechnology, and Biochemistry

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To determine the component-activity relationships of phytoncide solutions on inhibitory activity in melanin biosynthesis, four types of phytoncide solution (A-type, AB-type, D-type, and G-type) were evaluated for inhibition of mushroom tyrosinase activity and melanin synthesis on murine B-16 melanoma cells and a human reconstituted skin model. The A-type, AB-type, D-type, and G-type of phytoncide solution treatment resulted in significant inhibition of tyrosinase activity. The amount of melanin was increased by treatment with phytoncide solutions in a concentration-dependent manner on murine B-16 melanoma cells without affecting cell growth. Furthermore, phytoncide solutions also suppressed melanin synthesis in a concentration-dependent manner on a human reconstituted skin model. These effects of A-type solution were superior to those of other solutions.

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Antioxidative Effect of Citrus Essential Oil Components on Human Low-density LipoproteinIn Vitro

Cited by 53 publications

References 16 publications

Pharmaceutical and therapeutic Potentials of essential oils and their individual volatile constituents: a review

Pharmaceutical and therapeutic Potentials of essential oils and their individual volatile constituents: a review

Chemical composition and antimicrobial activity of the essential oil of Ferulago campestris (Besser) Grecescu growing in central Italy

Inhibitory Effects of Phytoncide Solution on Melanin Biosynthesis

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