Antioxidative effects of a novel dietary supplement Neumentix in a mouse stroke model

Taira, Yuki; Yamashita, Toru; Bian, Yuting; Shang, Jingwei; Matsumoto, Namiko; Nomura, Emi; Tsunoda, Keiichiro; Omote, Yoshio; Hishikawa, Nozomi; Ohta, Yasuyuki

doi:10.1016/j.jstrokecerebrovasdis.2020.104818

Cited by 7 publications

(4 citation statements)

References 28 publications

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“… 51 – 53 Moreover, the effect of SPE in the preservation of neurotrophin levels under neural stress conditions may further expand the suitability of including this ingredient in nutritional support dedicated to brain disorders, in which altered neurotrophism classically drives neurovascular breakout. 54 Although this is currently a hypothesis that requires specific investigations, the effects of SPE previously observed on the blood–brain barrier 18 and in models of stroke 19 may point on this direction. Nevertheless, the present results regarding SPE effects on neurotrophins provide an additional proposed mechanism for the cognitive function benefits already observed in clinical trials with SPE.…”

Section: Discussionmentioning

confidence: 98%

Efficacy of a Spearmint (Mentha spicataL.) Extract as Nutritional Support in a Rat Model of Hypertensive Glaucoma

Amato,

Canovai,

Melecchi

et al. 2023

Trans. Vis. Sci. Tech.

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Purpose Glaucoma is an eye–brain axis disorder characterized by loss of retinal ganglion cells (RGCs). Although the role of intraocular pressure (IOP) elevation in glaucoma has been established, the reduction of oxidative stress and inflammation has emerged as a promising target for neuronal tissue–supporting glaucoma management. Therefore, we evaluated the effect of a proprietary spearmint extract (SPE) on RGC density, activity, and neuronal health markers in a rat model of hypertensive glaucoma. Methods Animals were divided in four groups: untreated healthy control and three glaucomatous groups receiving orally administered vehicle, SPE-low dose, or SPE-high dose for 28 days. Ocular hypertension was induced through intracameral injection of methylcellulose at day 15. At day 29, rats underwent electroretinogram (ERG) recordings, and retinas were analyzed for RGC density and markers of neural trophism, oxidative stress, and inflammation. Results SPE exerted dose-dependent response benefits on all markers except for IOP elevation. SPE significantly improved RGC-related ERG responses, cell density, neurotrophins, oxidative stress, and inflammation markers. Also, in SPE-high rats, most of the parameters were not statistically different from those of healthy controls. Conclusions SPE, a plant-based, polyphenolic extract, could be an effective nutritional support for neuronal tissues. Translational Relevance These results suggest that SPE not only may be a complementary approach in support to hypotensive treatments for the management of glaucoma but may also serve as nutritional support in other ocular conditions where antioxidant, anti-inflammatory, and neuroprotective mechanism are often disrupted.

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Section: Discussionmentioning

confidence: 98%

Efficacy of a Spearmint (Mentha spicataL.) Extract as Nutritional Support in a Rat Model of Hypertensive Glaucoma

Amato,

Canovai,

Melecchi

et al. 2023

Trans. Vis. Sci. Tech.

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show abstract

“…The same research group then extended their findings of antioxidant actions mediated by RA, and observed robust mitigation of the damage to auditory signaling induced by D‐galactose in ovariectomized rats (Kantar‐Gok et al, 2017). In a murine model of acute stroke induced by transient middle cerebral artery occlusion (MCAO); Neumentix™, a naturally‐sourced spearmint‐based RA‐rich supplement, was found to elicit robust antioxidant effects and reduce infarction size (Taira et al, 2020). Ethyl acetate extracts of the roots of Scrophularia lucida containing RA as one of the bioactive phytochemicals was shown to elicit significant free radical scavenging activities in addition to inhibition of acetylcholinesterase (AChE) enzyme, a cholinergic target for the therapy of AD (Section 4.5.1), raising the possibility of employment of RA in management of neurodegenerative disorders (Zengin et al, 2019).…”

Section: Therapeutic Mechanisms Of Ramentioning

confidence: 99%

Molecular mechanisms of neuroprotective offerings by rosmarinic acid against neurodegenerative and other CNS pathologies

Ravaria

Saxena

et al. 2023

Phytotherapy Research

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Rosmarinic acid (RA) is a natural phenolic compound present in culinary herbs of the Boraginaceae, Lamiaceae/Labiatae, and Nepetoideae families. While the medicinal applications of these plants have been known for ages, RA has only been relatively recently established as an effective ameliorative agent against various disorders including cardiac diseases, cancer, and neuropathologies. In particular, several studies have confirmed the neuroprotective potential of RA in multiple cellular and animal models, as well as in clinical studies. The neuroprotective effects mediated by RA stem from its multimodal actions on a plethora of cellular and molecular pathways; including oxidative, bioenergetic, neuroinflammatory, and synaptic signaling. In recent years, RA has garnered tremendous interest as an ideal therapeutic candidate for treating neurodegenerative diseases. This review first briefly discusses the pharmacokinetics of RA and then proceeds to detail the neuroprotective mechanisms of RA at the molecular levels. Finally, the authors focus on the ameliorative potential of RA against several central nervous system (CNS) disorders, ranging from neuropsychological stress and epilepsy to neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Parkinson's disease, Lewy body dementia, and amyotrophic lateral sclerosis.

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“…including heart disease (Cortassa et al, 2021;Vujic et al, 2021), stroke (He et al, 2020;Taira et al, 2020), arteriosclerosis (Carmona-Maurici et al, 2020;Lian et al, 2019;Varona et al, 2017), diabetes (Michurina et al, 2020;Pal et al, 2020) and cancer (Shrivastava et al, 2021;Zahra et al, 2020). Furthermore, the oxidation of lipids by ROS is of great concern to the food industry and consumers because it causes food deterioration and the production of toxic compounds (Wang et al, 2016;Wang et al, 2018;Wang et al, 2019b;Wang et al, 2021).…”

Section: Fisheries and Aquatic Sciencesmentioning

confidence: 99%

Bioactive peptides-derived from marine by-products: development, health benefits and potential application in biomedicine

Pratama¹,

Putra²,

Pangestuti³

et al. 2022

Fish Aquat Sci

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Increased fisheries products have raised by-products that are discarded due to low economic value. In addition, marine by-products are still rich in protein and nutritional value that have biological activities and give benefits to human health. Meanwhile, there is raised pressure for sustainability practices in marine industries to reduce waste and minimize the detrimental effect on the environment. Thus, valorization by-products through bioactive peptide mining are crucial. This review focus on various ways to obtain bioactive peptides from marine by-products through protein hydrolysis, for instance chemical hydrolysis (acid and based), biochemical hydrolysis (autolysis and enzymatic hydrolysis), microbial fermentation, and subcritical water hydrolysis. Nevertheless, these processes have benefits and drawbacks which need to be considered. This review also addresses various biological activities that are favorable in pharmaceutical industries, including antioxidant, antihypertensive, anticancer, anti-obesity, and other beneficial bioactivities. In addition, some potential marine resources of Indonesia for the marine biopeptide from their by-product or undesired marine commodities would be addressed as well.

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Antioxidative effects of a novel dietary supplement Neumentix in a mouse stroke model

Cited by 7 publications

References 28 publications

Efficacy of a Spearmint (Mentha spicataL.) Extract as Nutritional Support in a Rat Model of Hypertensive Glaucoma

Efficacy of a Spearmint (Mentha spicataL.) Extract as Nutritional Support in a Rat Model of Hypertensive Glaucoma

Molecular mechanisms of neuroprotective offerings by rosmarinic acid against neurodegenerative and other CNS pathologies

Bioactive peptides-derived from marine by-products: development, health benefits and potential application in biomedicine

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