Antioxidative Effects of Campanula takesimana Nakai Extract

김미선,; 김경희,; 육홍선,

doi:10.3746/jkfn.2012.41.10.1331

Cited by 9 publications

(10 citation statements)

References 21 publications

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Section: Structure Elucidation Of New Compounds 1-3mentioning

confidence: 60%

“…By repetitive chromatographic separation of the hot water extract, three new neolignan glucosides (1)(2)(3) were isolated, along with 15 known compounds, including five lignans (4)(5)(6)(7)(8), five phenolic compounds (9-13), and five flavonoids (14)(15)(16)(17)(18), in the present research (Figure 1). It was reported that the n-butanol and ethyl acetate fractions of C. takesimana exhibit free radical-scavenging, tyrosinase inhibition, and superoxide dismutase (SOD)-like activities [2]. Although extensive research has been done on the pharmacological activities and/or phytochemical constituents of the plants belonging to family Campanulaceae, yet only few studies have been conducted on the genus Campanula, despite their frequent traditional use [3].…”

Section: Structure Elucidation Of New Compounds 1-3mentioning

confidence: 60%

“…Because it has long flowering period and shape of flower, this plant has been commonly cultivated for a decorative plant. Besides the value of horticulture, roots of C. takesimana have been used for herbal remedies for asthma, tonsillitis, and sore throat in traditional Korean medicine [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…It was reported that the n -butanol and ethyl acetate fractions of C. takesimana exhibit free radical-scavenging, tyrosinase inhibition, and superoxide dismutase (SOD)-like activities [ 2 ]. Although extensive research has been done on the pharmacological activities and/or phytochemical constituents of the plants belonging to family Campanulaceae, yet only few studies have been conducted on the genus Campanula , despite their frequent traditional use [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Thereafter, the isolates were assessed for their inhibitory effects on the production of the pro-inflammatory mediator, PGE 2 , in LPS-stimulated RAW264.7 macrophages. We describe in this paper the isolation of the secondary metabolites from the leaves of P. japonicus, structure elucidation of the three new neolignan glucosides (1)(2)(3), and inhibitory effects of the isolates on PGE 2 production.…”

Section: Introductionmentioning

confidence: 99%

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Chemical Constituents of the Leaves of Campanula takesimana (Korean Bellflower) and Their Inhibitory Effects on LPS-induced PGE2 Production

Choi

Son

et al. 2020

Plants

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Campanula takesimana Nakai (Campanulaceae; Korean bellflower) is one of the endemic herbs of Korea. The plant has been used as traditional medicines for treating asthma, tonsillitis, and sore throat in Korea. A hot water extract of the leaves of C. takesimana exhibited a significant inhibitory effect on lipopolysaccharide (LPS)-stimulated prostaglandin E2 (PGE2) production. Repetitive chromatographic separation of the hot water extract led to the isolation of three new neolignan glucosides, campanulalignans A–C (1–3), with 15 known compounds (4–18). The structures of new compounds 1–3 were elucidated by analyzing nuclear magnetic resonance (NMR) spectroscopic data, along with high resolution quadrupole time of flight mass (HR-Q-TOF-MS) spectrometric data. Among the isolates, simplidin (7), 5-hydroxyconiferaldehyde (11), icariside F2 (12), benzyl-α-l-arabinopyranosyl-(1″→6′)-β-d-glucopyranoside (13), and kaempferol 3-O-β-d-apiosyl (1→2)-β-d-glucopyranoside (15) were isolated from the Campanulaceae family for the first time. The isolates (1, 2, and 4–18) were assessed for their anti-inflammatory effects on LPS-stimulated PGE2 production on RAW 264.7 cells. 7R,8S-Dihydrodehydrodiconiferyl alcohol (5), 3′,4-O-dimethylcedrusin 9-O-β-glucopyranoside (6), pinoresinol di-O-β-d-glucoside (8), ferulic acid (10), 5-hydroxyconiferaldehyde (11), and quercetin (18) showed significant inhibitory effects on LPS-stimulated PGE2 production.

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Section: Structure Elucidation Of New Compounds 1-3mentioning

confidence: 60%

Section: Structure Elucidation Of New Compounds 1-3mentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Chemical Constituents of the Leaves of Campanula takesimana (Korean Bellflower) and Their Inhibitory Effects on LPS-induced PGE2 Production

Choi

Son

et al. 2020

Plants

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Plants from Ulleung island ameliorate lipid accumulation and oxidative stress in oleic acid-induced in HepG2 Cells

Kim¹,

Kim²

2020

Korean J. Food Preserv.

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Oxidative stress can directly damage lipids, proteins, and DNA, which promotes the progression from steatosis to nonalcoholic fatty liver disease. This study aimed to determine the antioxidative effects of Campanula takesimana Nakai, Ilex integra THUNB., Indigofera pseudotinctoria Matsum., Rubus takesimensis Nakai, and Tsuga sieboldii from Ulleung Island and their ability to inhibit lipid accumulation in HepG2 cells. The total phenolics (TPC) and flavonoid (TFC) contents of extracts of the five plants were determined, and their antioxidative activities were analyzed using DPPH and ABTS radical scavenging ability, Fe 2+ reducing capacity (FRAP), oxygen radical absorbance capacity (ORAC), and thiobarbituric acid assays. Lipid accumulation was evaluated by Oil Red O staining and intracellular triglyceride (TG) assays. Rubus takesimensis Nakai had the highest TPC among the five plants. The antioxidant activity of R. Nakai was DPPH (IC 50 =0.30 mg/mL), ABTS (IC 50 =0.33 mg/mL), FRAP (318.61 μmol FeSO 4 /g), and ORAC (1.74 μmol TE/g). The lipid peroxidation inhibitory effect of R. Nakai was reduced to 52.51% at 1 mg/mL. Incubating HepG2 cells with extracts of the five plants reduced lipid and TG accumulation by >50%, and inhibited lipid peroxidation by ~19%. These results provided evidence for the development of functional foods based on these five plants from Ulleung Island, due to their antioxidant activities and ability to reduce lipid accumulation.

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Effect of Nitrogen Fertilizer on the Growth and Antioxidant Activities of Prunella vulgaris and Campanula takesimana

정¹,

손²,

김³

et al. 2014

J. Korean Soc. People Plants Environ.

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This research was conducted to identify the effect of nitrogen form on the growth and antioxidant activities of native plants. Prunella vulgaris and Campanula takesimana were cultivated with a ebb and flow hydroponic system and treated with 3 nitrogen forms of nutrient solution of NO3-N, NH4-N, and mixed NO3/NH4-N. The growth of Prunella vulgaris and Campanula takesimana showed the best results in nutrient solution of NO3/NH4-N. Suppling the NO3/NH4-N fertilizer increased the contents of the total flavonoids in Prunella vulgaris. Total polyphenol content and DPPH scavenging activity, and NO scavenging activity were higher in NH4-N treatment, while suppling NO3-N decreased the contents of total flavonoids and total polyphenol, and the antioxidant activities of DPPH scavenging activity and NO scavenging activity.

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Antioxidative Effects of Campanula takesimana Nakai Extract

Cited by 9 publications

References 21 publications

Chemical Constituents of the Leaves of Campanula takesimana (Korean Bellflower) and Their Inhibitory Effects on LPS-induced PGE2 Production

Chemical Constituents of the Leaves of Campanula takesimana (Korean Bellflower) and Their Inhibitory Effects on LPS-induced PGE2 Production

Plants from Ulleung island ameliorate lipid accumulation and oxidative stress in oleic acid-induced in HepG2 Cells

Effect of Nitrogen Fertilizer on the Growth and Antioxidant Activities of Prunella vulgaris and Campanula takesimana

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