Antioxidative iridoid glycosides and phenolic compounds from Veronica peregrina

Kwak, Jong Hwan; Kim, Hyun Jung; Lee, Kwang Ho; Kang, Se Chan; Zee, Ok Pyo

doi:10.1007/s12272-009-1137-x

Cited by 71 publications

(42 citation statements)

References 23 publications

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“…The present study verified that CCl 4 induced acute liver damage, as demonstrated by increased serum markers of hepatic injury and histology. Specifically, the damage was associated with increased lipid peroxidation products and reduced antioxidative enzymes (22), indicating oxidative stress. Moreover, NF-κB was elevated, and TNF-α and IL-1β, which are pro-inflammatory cytokines regulated by this factor, were also increased.…”

Section: Discussionmentioning

confidence: 99%

Pien Tze Huang Gan Bao ameliorates carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats

Zhao

Wan

et al. 2017

Experimental and Therapeutic Medicine

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Liver damage results from a variety of insults, including hepatitis and chemical toxicity from alcohol, drugs and other toxins. The present study evaluated the hepatoprotective effects and potential mechanisms of action of the Traditional Chinese Medicine Pien Tze Huang Gan Bao (GB) in a rat model of carbon tetrachloride (CCl4)-induced liver injury. Sixty male Sprague-Dawley rats were randomly divided into six different groups: i) Control, ii) CCl4 injury model and groups treated with iii) silymarin as a positive drug control, iv) 150 mg/kg GB, v) 300 mg/kg GB and vi) 600 mg/kg GB. Control rats received no treatment, while the remaining ones were intraperitoneally injected with CCl4 (2 ml/kg) to induce acute liver disease. Silymarin or GB was orally administered prior to CCl4 treatment in various treatment groups for 7 days. Animals were sacrificed 24 h post-CCl4 injection. It was revealed that GB significantly reduced serum aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl transpeptidase and total bilirubin levels in the serum induced by CCl4. BG also prevented CCl4-induced changes in liver tissues, as revealed by histopathological analysis. CCl4-induced reductions in endogenous liver antioxidant enzyme activities of superoxide dismutase, glutathione and glutathione peroxidase as well as increases in malondialdehyde and thiobarbituric acid reactive substances were inhibited by GB treatment. Activated NF-κB in liver tissues was also significantly increased by CCl4, which was attenuated by GB as indicated by immunohistochemical and PCR analysis. Furthermore, CCl4-mediated increases in the inflammatory factors tumor necrosis factor-alpha and interleukin-1β secretion into the serum and their expression in liver tissues were reversed following GB treatment, as revealed by ELISA and PCR, respectively. These findings suggested that GB protects against CCl4-induced hepatic injury, inflammation and oxidative damage in rats and may be useful in future clinical application of liver injury and disease.

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Section: Discussionmentioning

confidence: 99%

Pien Tze Huang Gan Bao ameliorates carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats

Zhao

Wan

et al. 2017

Experimental and Therapeutic Medicine

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“…1), along with 24 known compounds . The structures of the known compounds were identified as rehmaglutins B (2) and D (3) [6], glutinoside (4) [7], catalpol (5) [8], specioside (6) [9,10], 6-O-cis-pcoumaroylcatalpol (7) [10], verminoside (8) [11], gmelinoside A (9) [12], dolichocymboside D (10) [13], 8-epiloganic acid (11) [14], citrusin C (12) [15], 4-allyl-2,6dimetnoxyphenyl glucoside (13) [16], eugenyl b-rutinoside (14) [17], decafeoylacteoside (15) [5], acteoside (16) [5], isoacteoside (17) [5], trans-leucosceptoside A (18) [18], cis-leucosceptoside A (19) [19], crenatoside (20) [20], (7S,8R)-dihydrodehydrodiconiferyl alcohol 4-O-glucoside (21) [21], citrusin B (22) [22], tricin 7-O-glucoside (23) [23,24], tricin 4 0 -O-glucoside (24) [24,25], and vitexin (25) [26] by comparison of their spectroscopic data with those reported in the literature. , four protons for cis and trans double bonds, and five protons for a monosubstituted benzene ring were observed.…”

Section: Resultsmentioning

confidence: 99%

A new iridoid glycoside and NO production inhibitory activity of compounds isolated from Russelia equisetiformis

et al. 2011

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From the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Russelia equisetiformis, one new iridoid glucoside was isolated along with 24 known compounds, comprising iridoids and iridoid glucosides, phenyl propane glucosides, phenyl ethanoids, lignan glucosides, and flavonoid glucosides. The structure of the new compound was elucidated to be 10-O-cinnamoyl sinuatol. Of the 25 compounds isolated, rehmaglutin B exhibited moderate inhibitory activity toward NO production, which was not associated with cytotoxicity.

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“…Mocan et al [12] found in veronica orchidea, officinallis, teucrium, antioxidants, phytochemical and antimicrobial. Dunkic et al [13] in veronica spicataconfirmed antioxidants plus antimicrobial while Exarchou [14] isolated compounds hispidulin also antiviral [15] an effective anti-cancer, anti-mutagenic and antitumor with new compounds [16][17][18][19] anti-ulcerogenic [20,21] anti-cholinesterase [22] antiinflammatory [18] anti-insecticidal [23] anti-hepatocarcinoma [24] antioxidants [25] angiogenic, neuroprotective potency [26] wound healing, cough, catarrh, and kidney medication [12] natural preservatives, dietary supplement, and hyperglycemia [27,28] was reported in this genus species, Javadsharif rad et al [29] found in veronica persicapoiracetylcholinesterase, scolicidal, tyrosinase, xanthine oxidase, lipoxygenase. Our current study is to focused only on antioxidant analysis by (1,1-diphenyl-2-picryl-hydrazyl) method and phytochemical confirmation also yield calculation for the first time in the genus veronica medicinal plant a specie veronica biloba.…”

Section: Introductionmentioning

confidence: 99%

The antioxidant activity and phytochemical analysis of medicinal plant Veronica biloba

2019

Lett Appl NanoBioSci

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A medicinal plant veronica genus has 450 well known species and found across both temperate and hemisphere region their 26 species are endemic and known in a total of 79 popular species and are widely utilized throughout the world due to important biological activities. In this study fully powdered uniform size specie veronica biloba plant taken in porous bag were manually subjected to soxhlet hot continuous process for cyclization of extraction using ethanol (300 mL) a concentrated dried extract obtained after solvent evaporation. Furthermore, liquid-liquid extracted fractions as water, dichloromethane, n-hexane, and ethyl acetate yields results found polar fraction with the highest percentage (water 47.51 %). The phytochemical screening of veronica biloba has shown all major compounds entirely present in extracts. One of the primitive phenolic compound flavonoid is present in plant and show potency towards antioxidants. All the extracted fractions of plant showed excellent antioxidant activity using a stable DPPH (1,1diphenyl-2-picryl-hydrazyl) method at concentration (range from 31.25 to 500µg/mL). Primary our ethyl acetate extract fraction showed the highest inhibition potential at IC 50 = 1.70±0.05µg/mL which is much closer to a standard positive control Propyl gallate showed IC 50 = 1.6±0.05µg/mL percent potential. The purification and isolation of these extract areimportant which can provide us help in novel antioxidants discovery also natural antioxidants currently in cosmetics products, food and therapeutics health related products significantly demanded because they are very effective, efficient and harmless as compared to synthetic.

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Antioxidative iridoid glycosides and phenolic compounds from Veronica peregrina

Cited by 71 publications

References 23 publications

Pien Tze Huang Gan Bao ameliorates carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats

Pien Tze Huang Gan Bao ameliorates carbon tetrachloride-induced hepatic injury, oxidative stress and inflammation in rats

A new iridoid glycoside and NO production inhibitory activity of compounds isolated from Russelia equisetiformis

The antioxidant activity and phytochemical analysis of medicinal plant Veronica biloba

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