Antioxidative phenolic compounds from a marine-derived fungus Aspergillus versicolor

Wu, Zhentian; Wang, Yongrui; Liu, Dong; Proksch, Peter; Yu, Siwang; Lin, Wenhan

doi:10.1016/j.tet.2015.10.038

Cited by 55 publications

(33 citation statements)

References 40 publications

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“…][ In the present work, a soft coral associated fungal strain Aspergillus versicolor LZD‐44‐03, was examined by the NMR and MS spectra. The spectroscopic data revealed that the fermented extract contains unknown metabolites in comparison with the compounds obtained from the different strains of the same fungal species what we reported previously …”

Section: Introductionsupporting

confidence: 65%

Varicuothiols A and B, New Fungal Metabolites from Aspergillus versicolor with Anti‐Inflammatory Activities

Chen

Liu

Guo

et al. 2017

Chemistry & Biodiversity

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Chemical examination of a coral-associated fungus Aspergillus versicolor LZD-44-03 resulted in the isolation of two new compounds with the trivial names of varicuothiols A (1) and B (2) as a unique scaffold. Their structures were determined through extensive spectroscopic analyses in association with the modified Mosher's method and chemical conversion. Both 1 and 2 exhibited significant inhibition against LPS-induced RAW24.7 cell proliferation, in association with the down regulation of nitrite production and cytokines (MCP-1, IL-6, and TNF-a).

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Section: Introductionsupporting

confidence: 65%

Varicuothiols A and B, New Fungal Metabolites from Aspergillus versicolor with Anti‐Inflammatory Activities

Chen

Liu

Guo

et al. 2017

Chemistry & Biodiversity

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“…The number of new natural products from marine bacteria reported in 2016 (179) is a modest increase from the average for those reported in the previous three years (161), but a signicant increase from the average for 2010-2012 (115). The genus Streptomyces continues to be the dominant force behind the discovery of new and exciting chemistry; numerous compounds from this prolic genus have also provided enticing bioactivities that will no doubt impact chemical biology and drug discovery/development in the future.…”

Section: Marine-sourced Bacteriamentioning

confidence: 90%

Marine natural products

et al. 2018

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Covering: 2016. Previous review: Nat. Prod. Rep., 2017, 34, 235-294This review covers the literature published in 2016 for marine natural products (MNPs), with 757 citations (643 for the period January to December 2016) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1277 in 432 papers for 2016), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that led to the revision of structures or stereochemistries, have been included.

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“…Within the area of Red Biotechnology, some investigations highlighted the potential of marine fungi to produce compounds of clinical interest with a wide array of antibacterial, anticancer, antiviral, and antioxidant applications [140][141][142][143][144]. In the last few decades, new antibiotics have failed due to increasing antibiotic resistance [145], and the ever-increasing demand for new natural bioactive compounds to provide benefits in all the aspects of human life has stimulated the exploration of other different Earth environments for improving the safeness and effectiveness of these molecules [146].…”

Section: Fungi In Dhabs As Potential Producers Of Biomolecules For Phmentioning

confidence: 99%

“…For instance, the isolated deep-sea fungus Aspergillus versicolor, which was also found in the Thetis basin, has shown high antifungal efficacy against human pathogens for the secretion of PeAfpA protein, becoming a promising candidate for its application in medicine [204]. The Aspergillus versicolor is also able to produce antioxidant compounds with potential therapeutic use or preventive agents for ROS-associated pathologies, such as neurodegenerative diseases (Alzheimer's and Parkinson's diseases) [144,184,205]. Other metabolites extracted from Aspergillus nidulans has shown the ability to inhibit the aggregation of tau filaments within neurons, which is the primary cause of Alzheimer's disease or other related dementias.…”

Section: Protective Agents Of Ldl Oxidation and Anti-atherosclerotic mentioning

confidence: 99%

Marine Fungi: Biotechnological Perspectives from Deep-Hypersaline Anoxic Basins

et al. 2019

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Deep-sea hypersaline anoxic basins (DHABs) are one of the most hostile environments on Earth. Even though DHABs have hypersaline conditions, anoxia and high hydrostatic pressure, they host incredible microbial biodiversity. Among eukaryotes inhabiting these systems, recent studies demonstrated that fungi are a quantitatively relevant component. Here, fungi can benefit from the accumulation of large amounts of organic material. Marine fungi are also known to produce bioactive molecules. In particular, halophilic and halotolerant fungi are a reservoir of enzymes and secondary metabolites with valuable applications in industrial, pharmaceutical, and environmental biotechnology. Here we report that among the fungal taxa identified from the Mediterranean and Red Sea DHABs, halotolerant halophilic species belonging to the genera Aspergillus and Penicillium can be used or screened for enzymes and bioactive molecules. Fungi living in DHABs can extend our knowledge about the limits of life, and the discovery of new species and molecules from these environments can have high biotechnological potential.

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Antioxidative phenolic compounds from a marine-derived fungus Aspergillus versicolor

Cited by 55 publications

References 40 publications

Varicuothiols A and B, New Fungal Metabolites from Aspergillus versicolor with Anti‐Inflammatory Activities

Varicuothiols A and B, New Fungal Metabolites from Aspergillus versicolor with Anti‐Inflammatory Activities

Marine natural products

Marine Fungi: Biotechnological Perspectives from Deep-Hypersaline Anoxic Basins

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