Antiparasitic activities of medicinal plants used in Ivory Coast

Timothée, Okpekon Aboua; Yolou, S; Gleye, Christophe; Roblot, François; Loiseau, Philippe M.; Bories, Christian; Grellier, Philippe; Frappier, François; Laurens, A.; Hocquemiller, Reynald

doi:10.1016/j.jep.2003.09.029

Cited by 185 publications

(146 citation statements)

References 16 publications

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“…This ability of essential oil to permit the preservation of smoked fish is explained by a high content of bio-actives components. This antimicrobial activity of essential oil of L. multiflora was already noted by Okpekon et al and Goly et al [25,24].…”

Section: Archives Of Clinical Microbiology Issn 1989-8436supporting

confidence: 75%

Antimicrobial and Preservative Activities of Lippia Multiflora Essential Oil on Smoked Mackerel (Scomber Scombrus) Fish

Cyrille¹,

Adjehi²,

Soro³

et al. 2017

Arch Clin Microbiol

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Section: Archives Of Clinical Microbiology Issn 1989-8436supporting

confidence: 75%

Antimicrobial and Preservative Activities of Lippia Multiflora Essential Oil on Smoked Mackerel (Scomber Scombrus) Fish

Cyrille¹,

Adjehi²,

Soro³

et al. 2017

Arch Clin Microbiol

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“…Traditional healing systems around the world that utilize herbal remedies are an important source for the discovery of new antibiotics (Okpekon et al, 2004); some traditional remedies have already produced compounds that are effective against antibiotic-resistant strains of bacteria (Kone et al, 2004). The results of this indicate the need for further research into traditional health systems (Romero et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial and phytochemical studies on twelve species of Indian medicinal plants

Parekh¹,

Chanda²

2010

African Journal of Biomedical Research

241

158

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“…and Perr. (Combretaceae) is widely used for some of its properties such as pest-destroying (Okpekon et al 2004), trypanocides (Shuaibu et al 2008) and antifungal (Batawila et al 2005). Recently, antibacterial activity of terpenoidal fractions from A. leiocarpus have been shown (Mann et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Endothelium-independent and endothelium-dependent vasorelaxation by a dichloromethane fraction from Anogeissus leiocarpus (dc) guill. Et Perr. (combretaceae): possible involvement of cyclic nucleotide phosphodiesterase inhibition

Belemnaba¹,

Ouédraogo²,

Auger³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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Many traditional medicinal herbs from Burkina Faso are used to treat arterial hypertension (HTA). Among them, Anogeissus leiocarpus (A. Leiocarpus) which is well known and widely used in Burkina traditional medicine. Herein we assess the effects of dichloromethane fraction from A. leiocarpus stem bark (ALF), selected as the most active on cyclic nucleotide phosphodiesterases (PDEs) and characterized its specificity towards purified vascular PDE1 to PDE5 isoenzymes and study its effects on a vascular model. ALF potently and preferentially inhibits (IC 50 =1.6 ± 0.6 µg/mL) the calmodulindependent phosphodiesterase PDE1, being mainly present in vascular smooth muscle and preferentially hydrolyses cGMP. In the same range (IC 50 =2.8 ±0.2 µg/ml) ALF inhibits PDE2, a cGMP-activated enzyme that is only present in endothelial cells and hydrolyses both cAMP and cGMP. PDE5, which specifically hydrolyses cGMP and which mainly contributes to cGMP hydrolysis is also potently inhibited by ALF (IC 50 =7.6±3.5 µg/ml). The potencies of ALF on cAMP hydrolyzing isoenzymes was lesser, being more effective on PDE4 (IC 50 = 17.6±3.5 µg/ml) than on PDE3 (60.9 ± 1.8 µg/ml). Since the major effect of ALF were against cGMP hydrolysis and since cGMP is implicated in endothelium-dependent relaxation, the endotheliumdependent vasorelaxation was studied on isolated porcine coronary arteries rings pre-contracted with U46619. The endothelium-dependent vasorelaxation is significantly inhibited by N ω -nitro-L-arginine (LNA 300 µmol/L, an inhibitor of endothelial NO synthase), but not affected by charybdotoxin (CTX, 100nM) plus apamin (APA, 100nM) (two inhibitors of EDHF-mediated responses). The combination of 4-aminopyridine (4-AP, 1 mmol/L, inhibitor of voltage-dependent potassium channels, K v ) plus baryum (Ba 2+ , 30 µmol/L, inhibitor of the potassium channels with entering correction, K ir ) plus ouabain (3 µmol/L, inhibitor of ATPase Na + /K + channels) partially inhibits endothelium-independent vasorelaxant effect. This endothelium-independent relaxant effect was also sensitive to combination of 1H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin-1-one (ODQ, 10 µM, soluble guanylyl cyclase inhibitor) and N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide dihydrochloride (H89, 100 nM, Protein Kinase A inhibitor). Taken together, these results indicate that ALF is a powerful vasodilator modulated by the formation of NO from endothelium, but also act by directly relaxing the vascular smooth muscle cells, by inhibiting cGMP hydrolyzing PDEs (PDE1, PDE2 and PDE5) and to a lesser extend on cAMP degradation (PDE3 and PDE4), cAMP and cGMP being second messengers involved in vascular relaxation.

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Antiparasitic activities of medicinal plants used in Ivory Coast

Cited by 185 publications

References 16 publications

Antimicrobial and Preservative Activities of Lippia Multiflora Essential Oil on Smoked Mackerel (Scomber Scombrus) Fish

Antimicrobial and Preservative Activities of Lippia Multiflora Essential Oil on Smoked Mackerel (Scomber Scombrus) Fish

Antibacterial and phytochemical studies on twelve species of Indian medicinal plants

Endothelium-independent and endothelium-dependent vasorelaxation by a dichloromethane fraction from <i>Anogeissus leiocarpus</i> (dc) <i>guill</i>. Et <i>Perr. (combretaceae)</i>: possible involvement of cyclic nucleotide phosphodiesterase inhibition

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