Antiparasitic activity of adermectin and compounds of a steroid nature

Джафаров, М. Х.; Zaitsev, S. Yu.; Мирзаев, М. Н.; Urazaev, D. N.; Maksimov, V. I.

doi:10.3103/s1068367410020163

Cited by 6 publications

(6 citation statements)

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“…In particular, benzimidazole derivatives, i.e. benzimidazolyl-chalcones (chalcones are flavonoids with an open pyran ring) [90], as well as 5-О-succinoyl avermectin and Gemacs on its basis [91][92][93] have been developed. These so-called horizontal developments are aimed at obtaining analogues with improved physical, chemical and pharmacological properties (e.g.…”

Section: New Anthelminthic Agentsmentioning

confidence: 99%

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Ecological, Physiological and Biochemical Adaptation in Helminth: Trends in Evolution of Anthelminthic Chemical Agents

Gorbachev¹

2021

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This paper discusses the landmark anthelminthic substancestraditional medicine components, different categories of pluripotential synthetic and naturally occurring compounds. Much attention is paid to the sections devoted to recent discoveries (Emodepside, Monepantel, Derquantel, Tribendimidine) and to some promising works. This review focused on some aspects of molecular mechanisms of action of anthelminthic substances and of helminth adaptation to anthelminthic substances, and on alternative worming treatment options. A new substance development, be it designing a new compound or identification of properties of any existing compounds, is a time-consuming and expensive process. Application of the diversification (different types of compounds) and the focused (related compounds) screenings, software-based evaluation of anthelminthic activity in silico, chemical and genetic trials on model small animals (nematodes Artemia salina, Caenorhabditis elegans, etc.) are intended to accelerate introduction of new substances. Further knowledge in molecular action mechanisms of anthelminthic agents and in resistance development would improve planning of helminthoses control protocols. Based on the systemic analysis of particular features of the chemical structure of anthelminthic substances, the hypothesis on the viability of the targeted search for such compounds among the derivatives of conditionally progenitor cyclic hydrocarbons benzene, indene, naphthalene, 1Н-cyclopenth [a]-naphthalene, anthracene and phenanthreneby alternating absolutely unsaturated and saturated structures, including heterocyclic analogues containing nitrogen, oxygen and sulfur and different substitutes and functional groups, was voiced.

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Section: New Anthelminthic Agentsmentioning

confidence: 99%

“…In this connection 8,14-[115], 9,10-and 9,11-secosteroids, e.g. analogues of Torgov seco-diketone, vitamin D 2 [116], 6,7-secoecdysteroids and others may also be promising. [110] plant bark and synthetic 14-metoxy-18-methyl-estron [111].…”

Section: Some Considerations For Synthetic Searchmentioning

confidence: 99%

Ecological, Physiological and Biochemical Adaptation in Helminth: Trends in Evolution of Anthelminthic Chemical Agents

Gorbachev¹

2021

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“…1 The avermectin family mainly includes ivermectin, doramectin, moxidectin, emamectin, and eprinomectin (EPR). [2][3][4][5][6] They are extremely effective against (endo-) internal and (ecto-) external parasites even in very low doses. Among the avermectin family, EPR was the rst drug licensed for the treatment of parasitic infections in lactating cows because of its low residue level in cattle milk.…”

Section: Introductionmentioning

confidence: 99%

Fabrication, characterization, and controlled release of eprinomectin from injectable mesoporous PLGA microspheres

et al. 2015

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“…Chemical modification of known substances allows obtaining new anthelmintics, as exemplified by derivatives of benzimidazole -benzimidazolyl-chalcones (chalcones -flavonoids with disclosed pyran ring) (96), and 5-O-succinoilavermectin -AI of the market drug Gemax (97)(98)(99) (Moscow). The purpose of this so-called horizontal research is creation of analogs with improved physicochemical and pharmacological properties (e.g., diminished residual content in breast milk after treatment during lactation, etc.).…”

Section: +mentioning

confidence: 99%

EVOLUTION IN CHEMOTHERAPY OF HUMAN AND ANIMAL HELMINTHIASES (review)

Джафаров¹

2013

S-h. biol.

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S u m m a r yThe attention is focused on the main classes of anthelmintics. Mode of action of the anthelmintics and the anthelmintic resistance, and alternative methods for dehelminthization are discussed. A targeted search for new anthelmintic substances in the series of speculative parental hydrocarbons (benzene, indene, naphthalene, 1 H1-cyclopenta [a]-naphthalene and phenanthrene) is suggested to be prospective on the basis of variation in their structure from the fully unsaturated to saturated forms, including those containing heteroatoms (N, O, S), various functional groups and substituents:

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Antiparasitic activity of adermectin and compounds of a steroid nature

Cited by 6 publications

References 1 publication

Ecological, Physiological and Biochemical Adaptation in Helminth: Trends in Evolution of Anthelminthic Chemical Agents

Ecological, Physiological and Biochemical Adaptation in Helminth: Trends in Evolution of Anthelminthic Chemical Agents

Fabrication, characterization, and controlled release of eprinomectin from injectable mesoporous PLGA microspheres

EVOLUTION IN CHEMOTHERAPY OF HUMAN AND ANIMAL HELMINTHIASES (review)

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