Phytochemical Resources for Medicine and Agriculture 1992
DOI: 10.1007/978-1-4899-2584-8_6
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Antiparasitic Agents from Plants

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Cited by 22 publications
(5 citation statements)
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“…The most important proposals for the control of the disease are campaigns to detect carriers and to eliminate the vector in order to stop new infections (Tonn, 1985). Present studies mainly consist of in vitro tests on the antiparasitic potential of plant extracts against Trypanosoma cruzii (MuelasSerrano et al, 2000) and on secondary metabolites, such as indole alkaloids or triterpenoids (Borris and Schaeffer, 1989). In Molinos, most of the vegetal therapeutic elements used to treat "heart" have been shown to be antispasmodic (Font Quer, 1983;Duke, 1985;Bézanger-Beauquesne et al, 1990;Che, 1991;Harborne and Baxter, 1993;Bisset, 1994).…”
Section: Discussionmentioning
confidence: 98%
“…The most important proposals for the control of the disease are campaigns to detect carriers and to eliminate the vector in order to stop new infections (Tonn, 1985). Present studies mainly consist of in vitro tests on the antiparasitic potential of plant extracts against Trypanosoma cruzii (MuelasSerrano et al, 2000) and on secondary metabolites, such as indole alkaloids or triterpenoids (Borris and Schaeffer, 1989). In Molinos, most of the vegetal therapeutic elements used to treat "heart" have been shown to be antispasmodic (Font Quer, 1983;Duke, 1985;Bézanger-Beauquesne et al, 1990;Che, 1991;Harborne and Baxter, 1993;Bisset, 1994).…”
Section: Discussionmentioning
confidence: 98%
“…Earlier studies [ 35 ], reported the oxidant generation potential of Acacia nilotica extract, based on the ability of the extract to increase conversion of reduced glutathione to oxidized glutathione. Increased oxidation has also been shown to create an intracellular environment that is unfavorable to plasmodial growth [ 36 , 37 ]. The mechanism of action of artemisinin, which depends on oxidant action for its potent antimalarial activity, validates this [ 35 ].…”
Section: Discussionmentioning
confidence: 99%
“…All four alkaloids are equally effective at killing Plasmodium spp. 3 In vitro, these four alkaloids have shown additive properties when combined, and a combination of quinine, quinidine, cinchonine, and cinchonidine was more effective than a total alkaloid extract of the bark. 4 The combination of quinine, quinidine and cinchonine is dramatically more effective than quinine alone against drug-resistant malaria in vitro.…”
Section: Multiple Alkaloids Versus Isolated Quininementioning
confidence: 98%