Antiparasitic agents produced by microorganisms

Shiomi, Kazuro; Ōmura, Satoshi

doi:10.2183/pjab.80.245

Cited by 24 publications

(19 citation statements)

References 88 publications

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“…Another derivative selamectin is highly effective against heartworms and fleas in companion animals (Michael et al 2002). Actinomycetes produce polyether antibiotics, such as monensin, lasalocid A and salinomycin, which are used to control poultry coccidiosis (Shiomi and Omura 2004). The application of anticoccidiales has significantly reduced the mortality and production loss caused by coccidiosis in poultry industry (Westley 1977).…”

Section: Other Therapeutic Agentsmentioning

confidence: 99%

Microbial metabolites in nutrition, healthcare and agriculture

et al. 2017

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Microorganisms are a promising source of an enormous number of natural products, which have made significant contribution to almost each sphere of human, plant and veterinary life. Natural compounds obtained from microorganisms have proved their value in nutrition, agriculture and healthcare. Primary metabolites, such as amino acids, enzymes, vitamins, organic acids and alcohol are used as nutritional supplements as well as in the production of industrial commodities through biotransformation. Whereas, secondary metabolites are organic compounds that are largely obtained by extraction from plants or tissues. They are primarily used in the biopharmaceutical industry due to their capability to reduce infectious diseases in human beings and animals and thus increase the life expectancy. Additionally, microorganisms and their products inevitably play a significant role in sustainable agriculture development.

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Section: Other Therapeutic Agentsmentioning

confidence: 99%

Microbial metabolites in nutrition, healthcare and agriculture

et al. 2017

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“…On the other hand, antibiotic resistance genes can be used as transformation markers without the prerequisite for any specific genetic background. It has been shown that several nematode species including helminth parasites are sensitive to broad-spectrum antibiotics [72,81]. Antibiotic resistance markers might therefore prove useful for researchers wanting to develop projects on nematodes lacking the C. elegans transgenesis toolbox.…”

Section: Application To Other Nematodesmentioning

confidence: 99%

Selectable genetic markers for nematode transgenesis

Giordano-Santini

Dupuy

2011

Cell. Mol. Life Sci.

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The nematode Caenorhabditis elegans has been used to study genetics and development since the mid-1970s. Over the years, the arsenal of techniques employed in this field has grown steadily in parallel with the number of researchers using this model. Since the introduction of C. elegans transgenesis, nearly 20 years ago, this system has been extensively used in areas such as rescue experiments, gene expression studies, and protein localization. The completion of the C. elegans genome sequence paved the way for genome-wide studies requiring higher throughput and improved scalability than provided by traditional genetic markers. The development of antibiotic selection systems for nematode transgenesis addresses these requirements and opens the possibility to apply transgenesis to investigate biological functions in other nematode species for which no genetic markers had been developed to date.

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“…Microorganisms produce many useful antiparasitic antibiotics [1]. In the course of screening for anthelmintic antibiotics, we have been interested in the differences in energy metabolisms between the host and helminths [2].…”

Section: Introductionmentioning

confidence: 99%