Paecilaminol, a New NADH-Fumarate Reductase Inhibitor, Produced by Paecilomyces sp. FKI-0550

Ui, Hideaki; Shiomi, Kazuro; Suzuki, Hideaki; Hatano, Hiroko; Morimoto, Hiromi; Yamaguchi, Yuichi; Masuma, Rokuro; Sakamoto, Kimitoshi; Kita, Kiyoshi; Miyoshi, Hideto; Tomoda, Hiroshi; Tanaka, Haruo; Ōmura, Satoshi

doi:10.1038/ja.2006.79

Cited by 19 publications

(13 citation statements)

References 24 publications

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“…Atpenins are the most potent complex II inhibitors, useful as tools for biochemical studies, though the inhibition is non-selective between helminths and mammals [5]. Paecilaminol is the first amino alcohol that has NFRD inhibitory activity [6].…”

Section: Introductionmentioning

confidence: 99%

Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083

Shiomi

Suzuki

et al. 2006

J Antibiot

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A new NADH-fumarate reductase inhibitor, verticipyrone, was isolated from the cultured broth of a fungus, Verticillium sp. FKI-1083. The structure was established as (E)-2-methoxy-3,5-dimethyl-6-(3-methyl-2-undecenyl)-4H-pyran-4-one. Verticipyrone exhibited an IC 50 value of 0.88 nM against NADH-fumarate reductase of Ascaris suum. Verticipyrone inhibited both Ascaris and bovine heart complex I, and its synthetic analogue, 8,9-dihydro-8-hydroxyverticipyrone, showed good selectivity against Ascaris complex I.

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Section: Introductionmentioning

confidence: 99%

Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083

Shiomi

Suzuki

et al. 2006

J Antibiot

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“…The marine-derived amino alcohols and related metabolites exhibited cytotoxic [5,6,8,9,16] and antimicrobial activities [2,7,10,12,13,15,17]. In our cytotoxicity assays of the natural and synthetic derivatives, compounds 1 – 5 , 8 – 10 , and 12 showed cytotoxicity against the A549 and K562 cell lines that was substantially lower than that of doxorubicin, whereas the other compounds were inactive (Table 4).…”

Section: Resultsmentioning

confidence: 99%

“…Since the first isolation of amino alcohols from Xestospongia sp. [2], several related compounds have been reported from marine ascidians [3,4,5,6,7,8,9,10], sponges [11,12,13,14,15], clams [16], and microorganisms [17]. These compounds exhibited interesting antimicrobial and cytotoxic activities.…”

Section: Introductionmentioning

confidence: 99%

Amino Alcohols from the Ascidian Pseudodistoma sp.

et al. 2014

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Seven new amino alcohol compounds, pseudoaminols A–G (1–7), were isolated from the ascidian Pseudodistoma sp. collected off the coast of Chuja-do, Korea. Structures of these new compounds were determined by analysis of the spectroscopic data and from chemical conversion. The presence of an N-carboxymethyl group in two of the new compounds (6 and 7) is unprecedented among amino alcohols. Several of these compounds exhibited moderate antimicrobial activity and cytotoxicity, as well as weak inhibitory activity toward Na+/K+-ATPase.

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“…Finally, the amino alcohol compound paecilaminol (144) was isolated from the cultured broth of the fungus Paecilomyces sp. FKI-0550 [77].…”

Section: Alkaloids and Other Nitrogen-containing Compoundsmentioning

confidence: 99%

A Systematic Review on Secondary Metabolites of Paecilomyces Species: Chemical Diversity and Biological Activity

Liu

et al. 2020

Planta Med

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AbstractFungi are well known for their ability to synthesize secondary metabolites, which have proven to be a rich resource for exploring lead compounds with medicinal and/or agricultural importance. The genera Aspergillus, Penicillium, and Talaromyces are the most widely studied fungal groups, from which a plethora of bioactive metabolites have been characterized. However, relatively little attention has been paid to the genus Paecilomyces, which has been reported to possess great potential for its application as a biocontrol agent. Meanwhile, a wide structural array of metabolites with attractive bioactivities has been reported from this genus. This review attempts to provide a comprehensive overview of Paecilomyces species, with emphasis on the chemical diversity and relevant biological activities of these metabolic products. Herein, a total of 148 compounds and 80 references are cited in this review, which is expected to be beneficial for the development of medicines and agrochemicals in the near future.

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Paecilaminol, a New NADH-Fumarate Reductase Inhibitor, Produced by Paecilomyces sp. FKI-0550

Cited by 19 publications

References 24 publications

Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083

Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083

Amino Alcohols from the Ascidian Pseudodistoma sp.

A Systematic Review on Secondary Metabolites of Paecilomyces Species: Chemical Diversity and Biological Activity

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