Antiparasitic Drugs. V. Anticoccidial Activity of 4-Amino-2-Ethoxy-benzoic Acid and Related Compounds

Rogers, Edward F.; Clark, Robert L.; Becker, Hans Joachim; Pessolano, A. A.; Leanza, W. J.; McManus, Edward C.; Andriuli, F.J.; Cuckler, A. C.

doi:10.3181/00379727-117-29616

Cited by 20 publications

(5 citation statements)

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“…Ethopabate, which is often used in combination with amprolium to improve the spectrum of efficacy, is a folate antagonist and blocks a step in the synthesis of para-aminobenzoic acid (PABA) and prevents the formation of nucleic acids of vitamins (Rogers et al 1964). It is most active against Eimeria maxima and Eimeria brunetti.…”

Section: Products Affecting Cofactor Synthesismentioning

confidence: 99%

Coccidiosis in poultry: anticoccidial products, vaccines and other prevention strategies

Peek

Landman

2011

Veterinary Quarterly

308

204

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Section: Products Affecting Cofactor Synthesismentioning

confidence: 99%

Coccidiosis in poultry: anticoccidial products, vaccines and other prevention strategies

Peek

Landman

2011

Veterinary Quarterly

308

204

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“…This drug has been widely used since 1960; often in combination with ethopabate or as in Europe, with ethopabate and sulphaquinoxaline in order to obtain a wide spectrum of activity (Rogers et al, 1964;Horton-Smith and Long, 1965). Field isolates of coccidia are often resistant to this drug and its combinations (Hodgson et al, 1969;Mathis and McDougald, 1982).…”

Section: Chemotherapeutic Treatmentmentioning

confidence: 98%

Gordon memorial lecture: Coccidiosis control: Past, present and future

1984

British Poultry Science

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Hygiene, management, chemotherapy and immunity all play a part in the control of coccidiosis. Under the conditions of modern intensive poultry rearing, special reliance is placed upon chemotherapy and since the introduction of the sulphonamides in 1939 a sequence of different types of drugs has been developed. At present the field is dominated by the ionophore antibiotics which have a special mode of action against the extracellular phases of the parasitic life cycle. Drug resistance is a continuing problem which has limited the effective life of most types of drug, although it has been most significant for particular compounds. So far it has not severely affected the efficacy of the ionophores. Immunity is involved in effective prophylaxis and the strong protective immunity which is a feature of most coccidial infections offers promise of a vaccination system. However, much more research will be necessary to bring this promise to fruition. Studies on immune mechanisms, antigenicity, biochemistry and in vitro cultivation may all contribute to the development of methods for controlling a series of infections which are an important obstacle to the development of modern husbandry methods.

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“…When T+ and R have the same activity, E equals the bivalent midpoint electrode potential Em, so that Em = 1/2(S1°+ E2°) + (RT/2F) In [H+] (6) The difference AE between E and Em at 30°then be-…”

Section: Semiquinone Ion Phenothiazine Phenazothionium Ionmentioning

confidence: 99%

Activity of phenothiazine anthelmintics as related to semiquinone formation

Tn¹,

Ld²,

Jc³

1969

J. Med. Chem.

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Antiparasitic Drugs. V. Anticoccidial Activity of 4-Amino-2-Ethoxy-benzoic Acid and Related Compounds

Cited by 20 publications

References 1 publication

Coccidiosis in poultry: anticoccidial products, vaccines and other prevention strategies

Coccidiosis in poultry: anticoccidial products, vaccines and other prevention strategies

Gordon memorial lecture: Coccidiosis control: Past, present and future

Activity of phenothiazine anthelmintics as related to semiquinone formation

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