Antiperistaltic effect and safety of l-menthol sprayed on the gastric mucosa for upper GI endoscopy: a phase III, multicenter, randomized, double-blind, placebo-controlled study

Hiki, Naoki; Kaminishi, Michio; Yasuda, Kenjiro; Uedo, Noriya; Honjo, Hajime; Matsuhashi, Nobuyuki; Hatori, Takashi; Sekine, Chuichi; Nomura, Sachiyo; Yahagi, Naohisa; Tajiri, Hisao; Suzuki, Hiroaki

doi:10.1016/j.gie.2010.12.013

Cited by 38 publications

(76 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The efficacy and safety of L-menthol were evaluated in this open-label extension study that included subjects who had been excluded from a previous phase III, placebocontrolled study [14]. The results indicated that intragastric spraying of L-menthol was effective and safe in nearly all patients of the study cohort undergoing upper GI endoscopy.…”

Section: Discussionmentioning

confidence: 99%

“…Patients were enrolled who required upper GI endoscopy, including those who had been excluded from an earlier placebo-controlled study of L-menthol [14] because they had reflux esophagitis (LA classification: B, C, D) or active gastric or duodenal ulcers, or had received sedation or transnasal endoscopy. The following exclusion criteria were applied to patients: (1) prior surgery involving upper GI tract; (2) severe gastric stenosis or deformation; (3) receiving treatment for cancer (chemotherapy or radiotherapy).…”

Section: Patientsmentioning

confidence: 99%

“…Recently, we reported that topical treatment with L-menthol, the major constituent of peppermint oil, effectively suppressed gastric peristalsis in a multicenter, randomized, double-blind, placebo-controlled trial [14]. The intragastric spraying of L-menthol was shown to be safe and to significantly increase the rate of complete suppression of gastric peristalsis as compared with placebo.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

An open-label, single-arm study assessing the efficacy and safety of l-menthol sprayed onto the gastric mucosa during upper gastrointestinal endoscopy

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

An open-label, single-arm study assessing the efficacy and safety of l-menthol sprayed onto the gastric mucosa during upper gastrointestinal endoscopy

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…20 Recently, efficacy of topical administration of L-menthol (Minclea ® ; Nihon Pharmaceutical Co., Ltd, Tokyo, Japan) on reduction of gastric peristalsis during EGD is indicated. [21][22][23] This agent shows few side-effects. Need for antispasmodics during screening endoscopy needs to be clarified by well-designed clinical studies.…”

Section: Edicalmentioning

confidence: 99%

Basic principles and practice of gastric cancer screening using high‐definition white‐light gastroscopy: Eyes can only see what the brain knows

Gotoda

Uedo

Yoshinaga³

et al. 2016

Digestive Endoscopy

Self Cite

View full text Add to dashboard Cite

Endoscopic diagnosis of gastrointestinal tumors consists of the following processes: (i) detection; (ii) differential diagnosis; and (iii) quantitative diagnosis (size and depth) of a lesion. Although detection is the first step to make a diagnosis of the tumor, the lesion can be overlooked if an endoscopist has no knowledge of what an earlystage 'superficial lesion' looks like. In recent years, image-enhanced endoscopy has become common, but white-light endoscopy (WLI) is still the first step for detection and characterization of lesions in general clinical practice. Settings and practice of routine esophagogastroduodenoscopy (EGD) such as use of antispasmodics, number of endoscopic images taken, and observational procedure are customarily decided in each facility in each country and are not well standardized. Therefore, in the present article, we attempted to outline currently available evidence and actual Japanese practice on gastric cancer screening using WLI, and provide tips for detecting EGC during routine EGD which could become the basis of future research.Key words: gastric atrophy, gastric cancer, Helicobacter pylori, Kimura-Takemoto classification, screening gastroscopy MEDICAL INTERVIEW PRIOR TO ESOPHAGOGASTRODUODENOSCOPY M EDICALINTERVIEW BEFORE esophagogastroduodenoscopy (EGD) is important in terms of the following two points. One is to confirm indication of the EGD and the other is to assess risk of examinees. Whether indication for EGD is to screen for early gastric cancer (EGC) or to make a diagnosis of a patient's symptoms or abnormal findings in other diagnostic examinations should be distinguished. In the screening endoscopy, the entire gastric mucosa is thoroughly observed to detect any suspicious findings for neoplasia, whereas only the presence of apparent lesions that may cause symptoms or abnormal image findings are investigated. Although endoscopy is usually intended to make a diagnosis of symptoms or abnormal findings in other diagnostic images, EGC are often found in patients with neither obvious symptoms nor abnormal findings in other diagnostic tests.1 Therefore, in high-risk patients, it is important to screen for EGC unrelated to symptoms or abnormal find-ings of other diagnostic tests during EGD. The examinee should be asked about status and history of eradication therapy of Helicobacter pylori (H. pylori), 2-4 family history of gastric cancer, smoking and drinking habits. [5][6][7][8] Another reason for the medical interview is to reduce 10 and an anti-foaming agent 11 reduces time and effort for washing out mucus or bubbles to improve quality of observation. A mixture of 4 mL anti-foaming agent (dimethicone, Gascon ® 20 mg/mL; Horii Pharmaceutical Industry, Osaka Japan), 20 000 U mucolytic agent (Pronase MS ® ; Kaken Pharmaceutical, Tokyo, Japan), and 1 g sodium bicarbonate dissolved in 50 mL water is given 10 min before the examination. 12Usefulness of a topical pharyngeal anesthetic is controversial although it is commonly used before gastroscopy. 13,14 UK data show that to...

show abstract

“…Эти препараты вводятся непосредственно перед исследованием и далее во время эндоскопи ческой процедуры. В последнее время опубликова ны сообщения об успешном применении раствора Lментола (0,8% раствор в объеме 20 мл) перораль но перед процедурой для подавления перистальти ческой активности [23][24][25], однако до настоящего времени не проводили хорошо спланированные клини ческие исследования, которые могли бы по казать влияние спазмолитиков на эффективность диагнос тики.…”

Section: спазмолитические препаратыunclassified

The modern endoscopic investigation of the stomach with the application of the narrow-band imaging endoscopy and magnifying endoscopy: procedural techniques and diagnostic algorithms

Kuvaev¹,

Kashin²

2016

Dok. gastroenterol.

View full text Add to dashboard Cite

a modern endoscopic study of the stomach includes, as an indispensable component, the application of additional visualization technologies, such as magnifying e endoscopy and narrow-band imaging endoscopy. The use of these techniques makes it possible to effectively diagnose pre-cancerous conditions and changes in the gastric mucosa as well as detect gastric cancer at the early stages of its development. The conduction of a modern endoscopic investigation implies the adequate preparation of the patient and the creation of the favourable conditions for the examination, the adequate alignment of the endoscopic equipment, the knowledge of the diagnostic algorithms by the attending physician and the necessary skills for their implementation.

show abstract

Antiperistaltic effect and safety of l-menthol sprayed on the gastric mucosa for upper GI endoscopy: a phase III, multicenter, randomized, double-blind, placebo-controlled study

Cited by 38 publications

References 26 publications

An open-label, single-arm study assessing the efficacy and safety of l-menthol sprayed onto the gastric mucosa during upper gastrointestinal endoscopy

An open-label, single-arm study assessing the efficacy and safety of l-menthol sprayed onto the gastric mucosa during upper gastrointestinal endoscopy

Basic principles and practice of gastric cancer screening using high‐definition white‐light gastroscopy: Eyes can only see what the brain knows

The modern endoscopic investigation of the stomach with the application of the narrow-band imaging endoscopy and magnifying endoscopy: procedural techniques and diagnostic algorithms

Contact Info

Product

Resources

About