Antiphosphatidylethanolamine antibodies contribute to the diagnosis of antiphospholipid syndrome in patients with systemic lupus erythematosus

Balada, Eva; Ordi‐Ros, Josep; Paredes, Fina; Villarreal, J.; Mauri, M; Vilardell‐Tarrés, Miquel

doi:10.1080/030097401316909594

Cited by 33 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1-4 Anti-PE (aPE) autoantibodies, also known as aPEs, are strongly associated with clinical cases of unexplained thrombosis. 5-9 Additionally, aPEs are highly associated with recurring fetal loss among pregnancies in humans. 10-12 This scenario is supported by genetic knockout studies in mice, where a deficiency in ethanolamine kinase 2, which is a key enzyme in PE bio-synthesis, results in placental thrombosis and fetal loss.…”

Section: Introductionmentioning

confidence: 99%

Phosphatidylethanolamine at the Luminal Endothelial Surface—Implications for Hemostasis and Thrombotic Autoimmunity

Wells

North

et al. 2009

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

Objective Accumulating evidence suggests that phosphatidylethanolamine (PE) is physically present at the luminal endothelial surface, where it tentatively functions as a critical anticoagulant. The goal of the current investigation was 3-fold: to characterize the distribution profile of PE at the luminal endothelial surface; to examine the immunoreactivity to the vascular endothelium by anti-PE (aPE) sera from patients presenting with thrombosis; and to discuss the potential mechanism of PE upregulation by endothelial cells. Methods The rat aortic arch was selected as major conduit vessel under significant hemodynamic burden. The presence of PE and the antigenic profile of aPE sera at the luminal endothelial surface were examined using duramycin as a PE-binding probe and immunohistochemistry. Phosphatidylethanolamine upregulation at endothelial cell surface was investigated using cultured monolayer subject to laminar shear stress or thrombin treatment. Results High levels of PE were detected at the luminal endothelial surface of aortic flow dividers, the ascending aorta, and the outer curvature of the aortic arch. The antigenic profiles of aPE sera, which are highly associated with elevated thrombotic risks in patients, are consistent with PE distribution along the endothelial surface. Finally, PE is upregulated at the surface of cultured endothelial cells in response to luminal shear stress but not thrombin. Conclusions The current data describe the physical distribution of vascular PE at the blood–endothelium interface. The luminal PE presents a vulnerability to anti-PE autoimmunity and is consistent with the association between aPE and elevated risk for idiopathic thrombosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Phosphatidylethanolamine at the Luminal Endothelial Surface—Implications for Hemostasis and Thrombotic Autoimmunity

Wells

North

et al. 2009

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

show abstract

Anticardiolipin Testing

Pierangeli

2006

Hughes Syndrome

View full text Add to dashboard Cite

Antiphospholipid Syndrome in the Absence of Standard Antiphospholipid Antibodies: Associations with Other Autoantibodies

Roubey

Hughes Syndrome

View full text Add to dashboard Cite

Antiphosphatidylethanolamine antibodies contribute to the diagnosis of antiphospholipid syndrome in patients with systemic lupus erythematosus

Abstract: The evaluation of IgG aPE may allow us to detect some more patients with aPL-related clinical manifestations in the SLE population, aPE correlated particularly with valvulopathies and livedo reticularis.

Cited by 33 publications

References 17 publications

Phosphatidylethanolamine at the Luminal Endothelial Surface—Implications for Hemostasis and Thrombotic Autoimmunity

Phosphatidylethanolamine at the Luminal Endothelial Surface—Implications for Hemostasis and Thrombotic Autoimmunity

Anticardiolipin Testing

Antiphospholipid Syndrome in the Absence of Standard Antiphospholipid Antibodies: Associations with Other Autoantibodies

Contact Info

Product

Resources

About