Antiphospholipid and Anti‐DNA Antibodies Are Not Associated with the Elevated Release of Circulatory Fetal DNA in Pregnancies Affected by Preeclampsia

Recent studies have provided new insight into aberrations in the immunological interplay between mother and fetus and their potential role in the development of recurrent fetal loss and preeclampsia. The action of anti-phospholipid antibodies in recurrent fetal loss is now proposed to involve the complement system, neutrophil activation and the production of TNFα by immune bystander cells. A clear involvement of the immune system is emerging in preeclampsia, involving mainly the innate arm, especially neutrophils. The activation of peripheral neutrophils by placentally released inflammatory debris triggers the induction of neutrophil extracellular traps (NETs), which may lead to an occlusion of the intervillous space, thereby further promoting a condition of placental hypoxia. It has, hence, been suggested that new therapeutic strategies be developed, including the possible use of TNFα antagonists in cases of recurrent miscarriage. These strategies need to be addressed with caution due to the possible induction of fetal congenital abnormalities.

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“…In our own analysis, we could not find any association between aPL and incidence of preeclampsia [30], a feature also observed by others [31].…”

Section: Preeclampsia: An Immune Disorder?supporting

confidence: 65%

Disturbances in placental immunology: ready for therapeutic interventions?

Hahn

Gupta

Troeger

et al. 2006

Springer Semin Immun

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“…For the analysis of cases with preeclampsia, we used a study cohort which has previously been described [10,11]. In the current study we used a subset of the initial cohort, in which the preeclampsia study group now consisted of 20 cases with the mild form and 20 cases with the severe form of the disorder and 20 gestational age-matched normotensive controls samples.…”

Section: Preeclampsia Samplesmentioning

confidence: 99%